Effects of magnesium‐substituted nanohydroxyapatite coating on implant osseointegration

Zhao, Shifang; Jiang, Qiao-hong; Peel, Sean; Wang, Xiaoxiang; He, Fuming

doi:10.1111/j.1600-0501.2011.02362.x

Cited by 80 publications

(65 citation statements)

References 35 publications

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“…36,37 It can promote hBMSCs or osteogenic cell proliferation as well as osteogenic differentiation. [38][39][40] In fact, Mg is found in natural enamel, dentine, and bone, and is associated with biologic apatite. Therefore, Mg is often incorporated into ceramics or adulterated into an alloy with other metal elements in order to promote osseous growth on implants.…”

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confidence: 99%

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

Zhou

Chen

et al. 2017

IJN

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Hydroxyapatite (HAP; Ca 10 (PO 4 ) 6 (OH) 2 ) and whitlockite (WH; Ca 18 Mg 2 (HPO 4 ) 2 (PO 4 ) 12 ) are widely utilized in bone repair because they are the main components of hard tissues such as bones and teeth. In this paper, we synthesized HAP and WH hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through microwave-assisted hydrothermal method. Then, we prepared HAP/chitosan and WH/chitosan composite membranes to evaluate their biocompatibility in vitro and prepared porous HAP/chitosan and WH/chitosan scaffolds by freeze drying to compare their effects on bone regeneration in calvarial defects in a rat model. The experimental results indicated that the WH/chitosan composite membrane had a better biocompatibility, enhancing proliferation and osteogenic differentiation ability of human mesenchymal stem cells than HAP/chitosan. Moreover, the porous WH/chitosan scaffold can significantly promote bone regeneration in calvarial defects, and thus it is more promising for applications in tissue engineering such as calvarial repair compared to porous HAP/chitosan scaffold.

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confidence: 99%

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

Zhou

Chen

et al. 2017

IJN

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“…The Mg containing calcium phosphates (MgCP), such as Mg substituted hydroxyapatite (Mg-HAP), has been shown as an attractive component to improve the biocompatibility of HAP coatings. For instance, Zhao et al [20] electrochemically deposited pure HAP and Mg-HAP coatings on the surface of pure titanium discs. They showed that the Mg-HAP…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Recently, growing interest has been devoted to a production of Mg containing biomaterials such as biocements [17], scaffolds [18] and coatings on metallic substrates [19][20][21] due to the beneficial biological effect of Mg emerging as a naturally occurring element in human body, especially in bones [22]. The Mg containing calcium phosphates (MgCP), such as Mg substituted hydroxyapatite (Mg-HAP), has been shown as an attractive component to improve the biocompatibility of HAP coatings.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

Strečková

Sopčák

Štulajterová

et al. 2018

Surface and Coatings Technology

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The needle-less electrospinning method was employed for a preparation of calcium phosphate (CP) and magnesium calcium phosphate (MgCP) fibers as biocompatible coatings on Ti substrate. The polyvinylalcohol, triethyl phosphite, calcium and magnesium nitrates were used for a preparation of spun solutions and subsequent precursor fiber formation. The citric acid of 10 wt% was added to the spun solution in order to increase conductivity as well as a convenient complexing agent. A possible mechanism of complexation process of triethyl phosphite with calcium and magnesium nitrates with citric acid is presented. The optimization of calcination temperatures was defined according to the results obtained from TG/DSC analysis. The XRD analysis confirmed the formation of hydroxyapatite and Mg-whitlockite phases at both used temperatures 600 and 800 °C. The final morphology and thickness of prepared CP and MgCP fibrous coatings was designed by a suitable choice of the used sols, spinning time and calcination temperature. The SEM/FIB observations revealed that the average thickness of the CP coating was around 1 μm, which is almost two times thinner than the MgCP coating with the approximate width 2 μm. The in vitro cytotoxicity tests of the substrate surfaces revealed that the osteoblastic MC3T3-E1 cells have a good proliferation activity when cultured on the 600°C calcined substrates covered by smooth and uniform fibrous nets. A strong cytotoxic cell response was observed in the samples treated at 800°C, where the fibrous coatings were disrupted by the newly formed sharp rutile (TiO 2 ) micro-crystals. Such surface topography acts against the initial adhesion and proliferation of osteoblast like cells.

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“…Já suas propriedades quer químicas, mecânicas ou biológicas, mostram que este é um importante precurssor de hidroxiapatita conforme Zhao et al (2011). Outra propriedade diz respeito confirma a formação de sítios de biomineralização descritos por Gartner (2003) ao notarmos a presença de células osteoprogenitoras como os osteoblastos, osteócitos e osteoclastos.…”

Section: Discussionunclassified

“…O fosfato de cálcio amorfo sugere atender tais requisitos . Suas propriedades químicas, mecânicas ou biológicas, mostram que este é um importante produto para a formação de hidroxiapatita in vivo ou in vitro (ZHAO et al, 2011 (ROSEMBERG, 1996). E de 3 a 5% de moléculas não colágenas são responsáveis pela promoção de sítios ativos para a biomineralização e para a adesão celular.…”

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<b>Avaliação histomorfométrica da neoformação óssea de enxertos de fosfato de cálcio amorfo e de hidroxiapatita em alvéolos dentais de ratos</b>

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Effects of magnesium‐substituted nanohydroxyapatite coating on implant osseointegration

Abstract: Mg-substituted HA coated surfaces promote osteogenic differentiation of preosteoblasts in vitro and may improve implant osseointegration during the early stages of bone healing compared with pure EDHA coated surfaces.

Cited by 80 publications

References 35 publications

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

<b>Avaliação histomorfométrica da neoformação óssea de enxertos de fosfato de cálcio amorfo e de hidroxiapatita em alvéolos dentais de ratos</b>

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