Effects of Malaria Infection on some Haematological and Biochemical Parameters in the General Population and Pregnant Malaria Patients Attending Two District Hospitals in Niger State, Nigeria

Abstract

The effects of malaria on some haematological and biochemical parameters among males, pregnant and non-pregnant female patients attending district hospitals in Bida and Kagara areas of Niger State, Nigeria was investigated. The subjects were volunteers confi rmed to be positive for malaria and without other clinical symptoms. A total of 231 patients (103 males and 128 females) within the age range of 1-50 years were studied. Fifty (20 males and 30 females) apparently healthy individuals in the similar age bracket were used as controls. Haematological and biochemical parameters were analyzed using standard methods. Overall, the reduction in haemoglobin concentration and packed cell volume (PCV) in patients were signifi cantly higher/lower from non-infected patients (p>0.05), while there was no signifi cant differences observed in the male patients. The mean cell haemoglobin concentration (MCHC) (36.03 ± 1.29g/dl) in pregnant subjects was signifi cantly higher (p<0.05) compared to the non-infected pregnant control group (32.65 ± 0.46g/dl). There was a signifi cant reduction in neutrophils but increase in lymphocytes in all subjects irrespective of sex. Non-signifi cant (p>0.05) increase existed in serum lipid levels among pregnant and non-pregnant women. When males and females were compared, serum lipids except triglycerides varied signifi cantly. There were apparently no variations in glucose levels between pregnant and nonpregnant subjects, whereas males had signifi cantly higher values. Some of these parameters can thus be useful tools in the monitoring and management of malaria.

Methanol extract of Erythrina senegalensis leaves (MEES) ameliorates Plasmodium berghei-ANKA 65-parasitised aberrations in mice

“…Also, the use of cholesterol and phospholipids by malaria parasites was hypothesized as a reason for the decrease in the level of serum HDL concentration following malaria parasite infection (Adamu and Jigam 2019). Changes in serum lipid profile during malaria infection and the underlying biological mechanisms remain unclear (Visser et al 2013).…”

“…The RBC membrane is made up of a complex mixture of lipids and proteins with cholesterol and distinct phospholipids making the core of the membrane which are arranged in a lipid bilayer (Kuypers 2007). During malaria parasite infection, the rupture of the RBCs can result in the elevation of plasma lipid levels (Adamu and Jigam 2019). However, treatment of the parasitised mice with graded doses of the MEES significantly (p < 0.05) increased the HDL concentration when compared with the parasitised-untreated mice group.…”

Evaluation of the antimalarial activity and toxicity of Mahanil-Tang-Thong formulation and its plant ingredients

“…In contrast, in a study on the general population and pregnant malaria patients, the activities of AST, ALP and total protein were elevated with a reduction in ALT, albumin and total bilirubin. The degree of alterations in these biochemical parameters depends on the level of parasitemia, nutritional status, malaria immunity and endemicity of the disease [ 46 ].…”

Duration of Storage Reduced Erythrocytes Profiles and Plasmodium Viability in Donor Blood

“… 29 , 30 The forming of new permeation pathways (NPP), an increase in permeability can be attributed to a single type of permeation pathway with characteristics quite distinct from those of the host. 31 , 32 A channel on the parasitophorous vacuole membrane (PVM) has been described 33 , 34 and projections from the PVM, called the tubulo-vesicular membrane network (TVM), have been implicated in the acquisition of nutrients. 34 , 35 These mechanisms proposed a direct connection of the Plasmodium spp.…”