Effects of mangosteen peel extract combined with demineralized freeze-dried bovine bone xenograft on osteocalcin, collagen 1, and osteoblast as alveolar bone regeneration in socket preservation

Kresnoadi, Utari; Raharjo, Tika; Rostiny, Rostiny

doi:10.4103/jips.jips_326_17

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…Osteocalcin can also be used as a biomarker in accurately evaluating the bone formation process. [ 13 14 ] As a result, this research aimed to analyze the role of a combination of Moringa leaf extract and DFDBBX for tooth extraction sockets preservation in generating osteocalcin, TGFβ1, and osteoblast expression.…”

Section: Introductionmentioning

confidence: 99%

The role of the combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (xenograft) as tooth extraction socket preservation materials on osteocalcin and transforming growth factor-beta 1 expressions in alveolar bone of Cavia cobaya

Kresnoadi¹,

Rahmania²,

Caesar³

et al. 2019

J Indian Prosthodont Soc

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Aim: Alveolar bone resorption, often occurring after tooth extraction, can be minimized through socket preservation. This process uses a combination of Moringa leaf extract and demineralized freeze-dried bovine bone xenograft (DFDBBX) that is expected to generate both transforming growth factor-beta 1 (TGF-β1) expressions as a transcription factor associated with osteoblast differentiation and osteocalcin accelerating alveolar bone formation. This research aimed to analyze the role of the combination of Moringa leaf extract and DFDBBX induced in socket preservation when generating TGF-β1 and osteocalcin expressions. Materials and Methods: The left mandibular incisors of 56 Cavia cobaya were extracted and divided into four groups subjected to different socket preservation treatments. The first group treated with polyethylene glycol, the second group with DFDBBX, the third group with Moringa leaf extract, and the fourth group with a combination of DFDBBX and Moringa leaf extract. The C. cobaya were examined on days 7 and 30, after which the specimens were sacrificed and examined using an immunohistochemical technique. The resulting data were then analyzed using one-way ANOVA and Tukey's honestly significant difference tests. Results: There was a significant difference in TGF-β1 and osteocalcin expressions between the groups ( P < 0.05). The highest mean amount of TGF-β1 and osteocalcin was found in the fourth group on both days 7 and 30. Conclusions: The combination of Moringa leaf extract and DFDBBX can effectively generate TGF-β1 and osteocalcin expressions during the preservation of tooth extraction sockets.

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Section: Introductionmentioning

confidence: 99%

The role of the combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (xenograft) as tooth extraction socket preservation materials on osteocalcin and transforming growth factor-beta 1 expressions in alveolar bone of Cavia cobaya

Kresnoadi¹,

Rahmania²,

Caesar³

et al. 2019

J Indian Prosthodont Soc

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“…Besides, it can potentially increase osteocalcin and collagen 1 expressions, thereby accelerating alveolar bone regeneration. [ 16 17 ] Another study showed that a combination of xenograft and Moringa leaf extract can effectively generate TGF-β1 and osteocalcin expressions during the preservation of tooth extraction sockets. [ 18 ] The increase in osteoblast cells in this study was strongly induced by the combination of propolis extract and BBG.…”

Section: Discussionmentioning

confidence: 99%

Propolis extract and bovine bone graft combination in the expression of VEGF and FGF2 on the preservation of post extraction socket

Kresnoadi

Lunardhi

Agustono

2020

J Indian Prosthodont Soc

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Aim: To determine the potential of propolis extract and BBG combination on the quantity of fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor (VEGF), and osteoblasts in the preservation of tooth extraction socket on days 3 and 7. Settings and Design: Laboratory in vivo reseach using animal model. Materials and Methods: Fifty-six Cavia cobaya were divided into eight groups containing seven animals in each group. The extraction socket on the lower left incisor was filled with polyethylene glycol (PEG) at a concentration of 2% (Groups I and II) as a control; active materials consisted of propolis extract and PEG (Groups III and IV); active materials consisted of BBG and PEG (Groups V and VI); and active materials consisted of propolis extract, BBG, and PEG (Groups VII and VIII). Then, an examination was done using immunohistochemistry to perform an expression of VEGF, FGF2, as well as histology of osteoblasts. Statistical Analysis Used: The statistical analysis performed using a one-way ANOVA and Tukey's honestly significant difference test. Results: Propolis extract, BBG and PEG had the most significant result related to the formation of FGF2, VEGF, and osteoblasts. Conclusion: The combination of propolis extract with BBG and PEG in socket preservation is effective in increasing the expression of FGF2, VEGF, and osteoblasts.

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“…On the other hand, alveolar ridge height is important for the retention and stabilization that constitute prerequisites to successful dental treatment. Therefore, tissue engineering for socket preservation is essential (Kresnoadi et al, 2018), while vascularization also constitutes an important factor in wound healing (Schiff, 2009).…”

Section: Journal Ofmentioning

confidence: 99%

“…Production of histopathological C. cobaya socket samples was completed at the Dr. Soetomo Anatomical Pathology Laboratory, Surabaya using Hematoxylin-Eosin (HE) stain to observe blood vessels and macrophages (Kresnoadi et al, 2018), while Masson Trichrome (MT) stain was employed to enable observation of collagen density (Rachmanita et al, 2019). The samples were subsequently examined by means of a light microscope (Shimadzu®, Japan) at 400x magnificationin order to establish the number of new blood vessels and macrophages present in the socket.…”

Section: Introductionmentioning

confidence: 99%

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Tissue repair in post extraction sockets of Cavia cobaya induced by a combination of propolis and graft

Kresnoadi

Halim

Putri

et al. 2020

Berkala Penelitian Hayati

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Propolis, hive defensive substance that contains caffeic acid phenethyl ester, can affect the migration and proliferation of cells involved in the healing process. Combination of propolis extract with BBG are predicted to fasten the wound healing, especially its effect on angiogenesis, macrophages and collagen density. In this study, we aimed to analyze the effect of a propolis combination and BBG in proliferating new blood vesselsand macrophages, while also increasing the collagen density of the post-extracted tooth socket healing process in Cavia cobaya. 56 C. cobaya, whose left mandibular incisorshad been extracted, were subsequently divided into four groups on the basis of the substances used to fill their sockets, namely; control, BBG, propolis extract, and a combination of BBG, and propolis extract. The subjects sacrificed on either the third or seventh day. Histopathological samples were produced using HE and MT staining. The results were subjected tosome statistical analysis tests: one-way analysis of variance (ANOVA), Tukey's honestly significant difference (HSD), Kruskal Wallis, and Mann Whitney. Significant increases (p<0.05) were detected between the PEG and PEG+Propolis groups and also between the PEG and PEG+BBG+Propolis combination groups. However, an insignificant increase (p>0.05) was identified between the PEG and BBG groups. In conclusion, a combination of BBG and propolis can increase the number of new blood vessels and macrophages together with the degree of collagen density in the healing process of post-extraction tooth sockets of C. cobaya.

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Effects of mangosteen peel extract combined with demineralized freeze-dried bovine bone xenograft on osteocalcin, collagen 1, and osteoblast as alveolar bone regeneration in socket preservation

Abstract: The administration of mangosteen peel extract combined with DFDBBX as a means of tooth extraction socket preservation can increase osteocalcin and collagen 1 expression. Consequently, osteoblasts as a means of alveolar bone regeneration will increase in number.

Cited by 9 publications

References 16 publications

The role of the combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (xenograft) as tooth extraction socket preservation materials on osteocalcin and transforming growth factor-beta 1 expressions in alveolar bone of Cavia cobaya

The role of the combination of Moringa oleifera leaf extract and demineralized freeze-dried bovine bone xenograft (xenograft) as tooth extraction socket preservation materials on osteocalcin and transforming growth factor-beta 1 expressions in alveolar bone of Cavia cobaya

Propolis extract and bovine bone graft combination in the expression of VEGF and FGF2 on the preservation of post extraction socket

Tissue repair in post extraction sockets of Cavia cobaya induced by a combination of propolis and graft

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