Effects of Mannooligosaccharides from Coffee on Microbiota and Short Chain Fatty Acids in Rat Cecum

Asano, Ichiro; Ikeda, Yoichi; Fujii, Shigeyoshi; Iino, Hisakazu

doi:10.3136/fstr.10.273

Cited by 28 publications

(14 citation statements)

References 17 publications

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“…(1995) also reported that over 95c~70 of SCFA produced in the large intestine were absorbed into the large intestinal epithelium cell. It was confirmed earlier that SCFA were signih~cantly increased in the cecum of rats fed diets containing MOS (Asano et a/., 2003). Accordingly, the absence of difference in fecal pH in the present experiment is also likely due to the rapid absorption of SCFA produced by MOS from the large intestlne.…”

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Effect of "Coffee Mix Drink" Containing Mannooligosaccharides from Coffee Mannan on Defecation and Fecal Microbiota in Healthy Volunteers

Umemura

Fujii

Asano

et al. 2004

FSTR

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Section: Discussionsupporting

confidence: 77%

“…Preparcltion ofc'~ff~e mi.v d/'ink The source of MOS was prepared by thermal hydrolysis of spent coffee grounds according to the procedure described in the previous report (Asano et al, 2003). The hydrolyzed slurry was fi~Itered and the filtrate was dried.…”

Section: Methodsmentioning

confidence: 99%

Effect of "Coffee Mix Drink" Containing Mannooligosaccharides from Coffee Mannan on Defecation and Fecal Microbiota in Healthy Volunteers

Umemura

Fujii

Asano

et al. 2004

FSTR

Self Cite

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“…A significantly higher level of propionate was found to be produced from MOSs compared to fructooligosaccharides and β‐1,4‐mannobiose 60 . Similar results for coffee MOSs were obtained in an in vivo rat study 61 . The addition of 5% MOSs to the diet for 28 days resulted in a proportional increase of up to 36.5 mmol/L of propionate in the cecum.…”

Section: Substrates Affecting Propionate Productionsupporting

confidence: 73%

“…60 Similar results for coffee MOSs were obtained in an in vivo rat study. 61 The addition of 5% MOSs to the diet for 28 days resulted in a proportional increase of up to 36.5 mmol/L of propionate in the cecum.…”

Section: Mannooligosaccharidesmentioning

confidence: 99%

Propionate as a health-promoting microbial metabolite in the human gut

et al. 2011

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Propionate is a major microbial fermentation metabolite in the human gut with putative health effects that extend beyond the gut epithelium. Propionate is thought to lower lipogenesis, serum cholesterol levels, and carcinogenesis in other tissues. Steering microbial propionate production through diet could therefore be a potent strategy to increase health effects from microbial carbohydrate fermentation. The present review first discusses the two main propionate-production pathways and provides an extended gene-based list of microorganisms with the potential to produce propionate. Second, it evaluates the promising potential of arabinoxylan, polydextrose, and L-rhamnose to act as substrates to increase microbial propionate. Third, given the complexity of the gut microbiota, propionate production is approached from a microbial-ecological perspective that includes interaction processes such as cross-feeding mechanisms. Finally, it introduces the development of functional gene-based analytical tools to detect and characterize propionate-producing microorganisms in a complex community. The information in this review may be helpful for designing functional food strategies that aim to promote propionate-associated health benefits.

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“…Several studies have shown that intake of 1–3 g/day of MOS can increase laxation frequency (15,18–20), as well as total fecal fat content (14,21). Further, in vitro (22) and animal studies (23,24) have indicated that MOS intestinal fermentation may increase the production of short‐chain fatty acids (SCFA) which may have an impact on lipid metabolism and subsequently improve insulin sensitivity. However, effects of MOS intake on thermogenesis and beta oxidation have not been examined.…”

Section: Introductionmentioning

confidence: 99%

A Weight‐Loss Diet Including Coffee‐Derived Mannooligosaccharides Enhances Adipose Tissue Loss in Overweight Men but Not Women

St‐Onge

Salinardi

Herron-Rubin

et al. 2012

Obesity

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Mannooligosaccharides (MOS), extracted from coffee, have been shown to promote a decrease in body fat when consumed as part of free-living, weight-maintaining diets. Our objective was to determine if MOS consumption (4 g/day), in conjunction with a weight-loss diet, would lead to greater reductions in adipose tissue compartments than placebo. We conducted a double-blind, placebo-controlled weight-loss study in which 60 overweight men and women consumed study beverages and received weekly group counseling for 12 weeks. Weight and blood pressure were measured weekly, and adipose tissue distribution was assessed at baseline and at end point using magnetic resonance imaging. A total of 54 subjects completed the study. Men consuming the MOS beverage had greater loss of body weight than men consuming the Placebo beverage (−6.0 ± 0.6% vs. −2.3 ± 0.5%, respectively, P < 0.05). Men consuming the MOS beverage also had reductions in total body volume (P < 0.0001), total (P < 0.0001), subcutaneous (P < 0.0001), and visceral (P < 0.05) adipose tissue that were greater than changes observed in those consuming the Placebo beverage. In women, changes in body weight and adipose tissue compartments were not different between groups. Adding coffee-derived MOS to a weight-loss diet enhanced both weight and adipose tissue losses in men, suggesting a potential functional use of MOS for weight management and improvement in adipose tissue distribution. More studies are needed to investigate the apparent gender difference in response to MOS consumption.

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Effects of Mannooligosaccharides from Coffee on Microbiota and Short Chain Fatty Acids in Rat Cecum

Cited by 28 publications

References 17 publications

Effect of "Coffee Mix Drink" Containing Mannooligosaccharides from Coffee Mannan on Defecation and Fecal Microbiota in Healthy Volunteers

Effect of "Coffee Mix Drink" Containing Mannooligosaccharides from Coffee Mannan on Defecation and Fecal Microbiota in Healthy Volunteers

Propionate as a health-promoting microbial metabolite in the human gut

A Weight‐Loss Diet Including Coffee‐Derived Mannooligosaccharides Enhances Adipose Tissue Loss in Overweight Men but Not Women

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