Effects of manure and mineral fertilization strategies on soil antibiotic resistance gene levels and microbial community in a paddy–upland rotation system

Lin, Hui; Sun, Wanchun; Zhang, Zulin; Chapman, Stephen J.; Freitag, Thomas E.; Fu, Jing-Li; Zhang, Xin; Ma, Junwei

doi:10.1016/j.envpol.2016.01.007

Cited by 87 publications

(28 citation statements)

References 40 publications

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“…There is a long history of metals, including Cu and Zn, being linked to antibiotic resistance development in environmental bacteria, with many studies showing a correlation between the presence of either of these two metals in environmental samples and the concomitant presence of metal‐tolerant and antibiotic‐resistant populations, or the increased prevalence of antibiotic‐resistant genes/organisms in metal‐contaminated versus metal‐free environments . Moreover, the impact of Cu on antimicrobial resistance is higher compared with other metals …”

Section: Discussionmentioning

confidence: 99%

“…34,35 There is a long history of metals, including Cu and Zn, being linked to antibiotic resistance development in environmental bacteria, with many studies showing a correlation between the presence of either of these two metals in environmental samples and the concomitant presence of metal-tolerant and antibiotic-resistant populations, or the increased prevalence of antibiotic-resistant genes/organisms in metal-contaminated versus metal-free environments. 18,19,36 Moreover, the impact of Cu on antimicrobial resistance is higher compared with other metals. 37,38 According to results from the present study, most olive farm soils had low Cu concentrations with an average of 15 mg kg −1 (which would be equivalent to approximately between 0.2 and 0.3 mmol L −1 Cu) and only two soils had higher concentrations of 78 mg kg −1 (ca 1.1-1.4 mmol L −1 ) and 129 mg kg −1 (ca 1.8-2.4 mmol L −1 ).…”

Section: Discussionmentioning

confidence: 99%

“…10 There are clearly established links between the resistance genes found in soil and animals and resistance genes found in humans, including human pathogenic bacteria, with antibiotic resistance genes found in the former also present in human pathogens. 11,12 These links have been seen in diverse environments that include industrial, 13,14 clinical, 15 aquatic 13,16 (including wastewater) 17 and, especially, agricultural [18][19][20][21][22] settings.…”

Section: Introductionmentioning

confidence: 99%

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Copper tolerance and antibiotic resistance in soil bacteria from olive tree agricultural fields routinely treated with copper compounds

et al. 2019

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BACKGROUND Heavy metal pollution may act as persistent selective pressure that favors the spread of antimicrobial resistance in natural environments. The aim of this study was to isolate and identify metal‐tolerant bacteria from soils in olive tree fields routinely treated with copper‐derived compounds and to evaluate the tolerance of bacterial strains to other metals and their resistance to clinically relevant antibiotics. RESULTS Five hundred and ninety‐five bacterial isolates from 45 olive tree agricultural fields were studied. Minimum inhibitory concentrations (MICs) ≥ 16 mmol L−1 were detected for copper (57% of isolates), zinc (37%) and lead (62%), while only 3% had MICs ≥ 12 mmol L−1 for nickel. Ninety‐six metal‐tolerant strains were selected for identification and antibiotic resistance determination. Most isolates belonged to the genera Pseudomonas (37%), Bacillus (23%) and Chryseobacterium (20%), while 6% were identified as Variovorax, 4% as Stenotrophomonas and 2% as Serratia or Burkholderia. Highest copper tolerance was detected among Pseudomonas. Over 75% of the strains with high copper tolerance were also resistant to vancomycin, 50% to ampicillin and 40% to erythromycin or trimethoprim/sulfamethoxazole. CONCLUSION Bacteria from olive soils are tolerant to metals, mainly copper, but also zinc and lead, as well as resistant to clinically important antibiotics, which could be a troublesome issue in clinical settings. © 2019 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Copper tolerance and antibiotic resistance in soil bacteria from olive tree agricultural fields routinely treated with copper compounds

et al. 2019

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“…Most publications are on sewage (n = 31) and most focus on the occurrence of toxic metal resistant bacteria, rather than on the ability of metals to induce resistance in bacteria in the environment. Eight articles were regarding PTM resistance in manure [35][36][37][38][39][40][41][42].…”

Section: Links Between Resistance Towards Potentially Toxic Metals Anmentioning

confidence: 99%

Antimicrobial resistance due to the content of potentially toxic metals in soil and fertilizing products

Yazdankhah

Skjerve

Wasteson

2018

Microbial Ecology in Health and Disease

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Potentially toxic metals (PTM), along with PTM-resistant bacteria and PTM-resistance genes, may be introduced into soil and water through sewage systems, direct excretion, land application of biosolids (organic matter recycled from sewage, especially for use in agriculture) or animal manures as fertilizers, and irrigation with wastewater or treated effluents. In this review article, we have evaluated whether the content of arsenic (As), cadmium (Cd), chromium (CrIII + CrVI), copper (Cu), lead (Pb), mercury (Hg), nickel (Ni), and zinc (Zn) in soil and fertilizing products play a role in the development, spreading, and persistence of bacterial resistance to these elements, as well as cross-or co-resistance to antimicrobial agents. Several of the articles included in this review reported the development of resistance against PTM in both sewage and manure. Although PTM like As, Hg, Co, Cd, Pb, and Ni may be present in the fertilizing products, the concentration may be low since they occur due to pollution. In contrast, trace metals like Cu and Zn are actively added to animal feed in many countries. In several studies, several different bacterial species were shown to have a reduced susceptibility towards several PTM, simultaneously. However, neither the source of resistant bacteria nor the minimum co-selective concentration (MCC) for resistance induction are known. Co-or cross-resistance against highly important antimicrobials and critically important antimicrobials were identified in some of the bacterial isolates. This suggest that there is a genetic linkage or direct genetic causality between genetic determinants to these widely divergent antimicrobials, and metal resistance. Data regarding the routes and frequencies of transmission of AMR from bacteria of environmental origin to bacteria of animal and human origin were sparse. Due to the lack of such data, it is difficult to estimate the probability of development, transmission, and persistence of PTM resistance.

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“…However, the widespread use of dietary zinc oxide in intensive animal production can result in pollution of farmlands and groundwater through repeated fertilisation with zinc-containing residual manure (Hill et al, 2005). In addition, zinc oxide in combination with antibiotics appears to accelerate microbial antibiotic resistance by increasing the rate of the exchange of antibiotic-resistance-gene containing plasmids in the microbiota community in both soil and piglet intestines (Lin et al, 2016;Pal et al, 2015 ;Vahjen et al, 2015); thus, there is a need to reduce both kinds of interventions.…”

Section: Introductionmentioning

confidence: 99%

Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea

Hedegaard

Lauridsen

Heegaard

2017

Veterinary Immunology and Immunopathology

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Enteric infectious disease in weaner piglets, including postweaning diarrhoea (PWD), are usually treated and/or prevented with antibiotics and/or zinc oxide in the piglet feed. However extensive use of antibiotics and zinc oxide in intensive animal production is unwanted as it may promote microbial antibiotic resistance and pose environmental problems. Recently, in an experimental model of PWD, we observed that oral administration of purified porcine immunoglobulin G (ppIgG) from pooled natural pig plasma could reduce enteric infection. In the present study we were able to reproduce these results as it was observed that oral ppIgG accelerated clearance of faecal haemolytic bacteria in pigs challenged with E. coli in comparison with pigs not receiving ppIgG. This effect was observed upon feeding ppIgG for seven days postweaning suggesting that ppIgG does not have to be used prophylactically for several days preweaning. Furthermore, the effect of oral administration of ppIgG for seven days postweaning was equal to or better than that of dietary zinc oxide in reducing diarrhoea symptoms and in clearing faecal haemolytic bacteria for 14days postweaning. These observations warrant future trials of dietary ppIgG in intensive swine production units to establish its performance as an alternative to dietary antibiotics and zinc oxide for preventing PWD.

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Effects of manure and mineral fertilization strategies on soil antibiotic resistance gene levels and microbial community in a paddy–upland rotation system

Cited by 87 publications

References 40 publications

Copper tolerance and antibiotic resistance in soil bacteria from olive tree agricultural fields routinely treated with copper compounds

Copper tolerance and antibiotic resistance in soil bacteria from olive tree agricultural fields routinely treated with copper compounds

Antimicrobial resistance due to the content of potentially toxic metals in soil and fertilizing products

Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea

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