Effects of Marijuana Use in Patients with Orthopaedic Trauma

Abstract

The use of cannabis and cannabis-related products has increased dramatically in the last 2 decades. As states continue to legalize cannabis products, it is important for surgeons to understand the effects they may have on patients who have sustained orthopaedic trauma.Cannabinoids have been shown to decrease the severity of certain symptoms related to traumatic brain injury as well as posttraumatic stress disorder.Cannabinoids can modulate the body’s endocannabinoid system, which can play an important role in bone homeostasis. Activation of cannabinoid receptors has been shown to be bone-protective in adults.Venous thromboembolism is a major concern for trauma patients. Cannabis use has been linked to overall increased rates of venous thromboembolism events.Literature regarding human-based cannabis studies is sparse; however, the growing field is opening new opportunities for research of this topic.

Veterans and Medical Cannabis: A Perfect Federalism Storm

“…Retrospective studies in humans have also found benefits in terms of sleep and mood, but not direct therapeutic effects on brain injury. Right now the literature does not support a beneficial effect for TBI, but the research is also limited (Sheppard et al, 2021). Physicians, however, have reported that their patients are using cannabis for self-treatment of TBI and that doctors are not well informed of the limited evidence of its efficacy (Grenier et al, 2020).…”

Detection value of D-dimer, C-reactive protein, ESR and blood routine in the perioperative treatment of orthopaedic trauma patients

“…C-reactive protein is not only a non-specific validation marker, but also plays an important protective role in the innate immune process of the body, and is involved in inflammation and atherosclerosis and other cardiovascular diseases. Therefore, C-reactive protein is also an important risk factor for cardiovascular diseases (14)(15). C-reactive protein is increased in various acute inflammation, respiratory tract infection, malignant tumor and other diseases, but the specificity is not high.…”