Effects of marine β−1,3 glucan on immune reactions

Větvička, Václav; Yvin, Jean-Claude

doi:10.1016/j.intimp.2004.02.007

Cited by 147 publications

(116 citation statements)

References 33 publications

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“…In addition to the fungal cell walls, -glucan is also isolated from seaweed laminaran from Laminaria hyperborea, linear (1 →3)-d-glucan (Black et al, 1951) and commercially sold as Phycarine (Vetvicka and Yvin, 2004). It is also produced by bacteria (curdlan from Alcaligenes faecalis) (Harada et al, 1968) and is an ingredient of cereal.…”

Section: Introductionmentioning

confidence: 99%

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Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

Větvička

Větvičková

2009

Journal of Immunotoxicology

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Section: Introductionmentioning

confidence: 99%

“…Some studies suggest the role of macrophages in cholesterol metabolism (Schmitz et al, 1986;Frey and De Maio, 2007). Since macrophages are strongly influenced by glucan (Vetvicka and Yvin, 2004), we first evaluated if the studied glucans are stimulating cells of the macrophage lineage.…”

Section: Introductionmentioning

confidence: 99%

Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

Větvička

Větvičková

2009

Journal of Immunotoxicology

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“…Their beneficial effects on the immune system and the lack of toxic or adverse effects has focused studies on -glucan molecules [38]. -glucans are acknowledged to be one of the immune response modifiers [6].…”

mentioning

confidence: 99%

“…-glucans are acknowledged to be one of the immune response modifiers [6]. Studies conducted over the past decade have shown that -glucans inhibit tumor development [28,38], enhance defense against bacterial infection [15,24], activate macrophages [8], induce production of cytokines [10,34], nitric oxide (NO) and arachidonic acid metabolites [14,21], increase hematopoiesis [35], exert radioprotective effects [12], are effective against burns [9,37], improve wound healing by inducing the macrophage release of wound growth factors [40] and lower serum lipids [4,23]. Among the several mechanisms proposed for the protective effects of -glucans, the major one is related to antioxidant capacity of the molecules [1,20], which has been further proven by Kogan et al [16] using electron paramagnetic response spectroscopy.…”

mentioning

confidence: 99%

Hepatoprotective Effects of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z, on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Sugiyama

Suzuki²,

Mitra³

et al. 2009

J. Vet. Med. Sci.

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ABSTRACT. Paramylon is a -(1-3)-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the protective effects of paramylon on liver injury induced by carbon tetrachloride (CCl 4 ) in rats. Wistar stain male rats were orally administered paramylon (500, 1,000 and 2,000 mg/kg body weight) before treatment with a single intraperitoneal dose of 50% CCl 4 (2 ml/kg body weight). The rats were sacrificed 24 hr later, and blood samples were collected for assay of serum biochemical parameters. The livers were excised to evaluate the activity of antioxidant enzymes. Histopathological examination of the livers was also performed. The results showed that the treatment of paramylon prevented elevation of the serum levels of hepatic enzyme markers and inhibited fatty degeneration and hepatic necrosis induced by CCl 4 . Pre-administration of paramylon reduced the liver apoptotic index. The treatment of paramylon recovered reductions of activity of hepatic superoxide dismutase, catalase and glutathione peroxidase induced by CCl 4 . These results demonstrate that paramylon exhibits protective action on acute hepatic injury induced by CCl 4 via an antioxidative mechanism. To the best of our knowledge, this is the first report of a hepatoprotective effect based on the antioxidative action of paramylon.

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“…Mushrooms have high nutritional value (Mattila et al, 2001;Barros et al, 2008;Reis et al, 2012;Carneiro et al, 2013); they are low-fat, high in protein, and contain vitamins, minerals, and trace element constituents with nutraceutical composition. Of the nutraceuticals, homopolysaccharides are the best known molecules; they play an essential role as an immunomodulator (Manzi and Pizzoferrato, 2000;Mayell, 2001;Vetvicka and Yvin, 2004), as well as exhibit anticancer, antibacterial, antioxidant, and anti-inflammatory properties (Yu et al, 2009;Zhang et al, 2011;Chang and Wasser, 2012;Finimundy et al, 2013). Therefore, mushrooms are not only a component of a balanced diet, but also provide key medicinal uses in the treatment of certain diseases.…”

Section: Introductionmentioning

confidence: 99%

Detection of a Non-animal Source of Glycosaminoglycans from Edible Mushrooms in Northern Thailand

Choocheep¹,

Nathip²

2018

CMUJNS

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Several kinds of cultivated or local edible mushrooms exist in northern Thailand. While their nutritional features have been extensively analyzed, the presence of phytochemicals and glycosaminoglycans has yet to be investigated. Thus, in this study, we examined the presence of phytochemicals and glycosaminoglycans from 10 cultivated or local mushrooms: milk white russula, hygroscopic earthstar, log white fungi, log black fungi, shitake mushroom, rosy russula, sajor-caju mushroom, Jew's ear, bolete, and straw mushroom. Phytochemical analysis revealed the presence of carbohydrates, amino acids, and flavonoids in the extracts from most of the mushrooms. We detected glycosaminoglycans in all of the extracts using dimethylmethylene blue (DMMB) dye-binding assay and UVVis spectrophotometry. Hygroscopic earthstar contained the most glycosaminoglycans and sajor-caju mushroom the least. However, we were unable to distinguish the types of glycosaminoglycans, which should be considered for future study. In summary, the phytochemicals found here are crucial non-animal dietary sources of carbohydrates, amino acids, and antioxidants. In addition, the glycosaminoglycans detected in the mushroom extracts in this study potentially offer a non-animal source of glycosaminoglycans that may have clinical applications, apart from their nutritive value.

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Effects of marine β−1,3 glucan on immune reactions

Cited by 147 publications

References 33 publications

Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

Effects of yeast-derived β-glucans on blood cholesterol and macrophage functionality

Hepatoprotective Effects of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z, on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Detection of a Non-animal Source of Glycosaminoglycans from Edible Mushrooms in Northern Thailand

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