Effects of Maternal Exposure to a Reconstituted Mixture of Polychlorinated Biphenyls on Sex-Dependent Behaviors and Steroid Hormone Concentrations in Rats: Dose–Response Relationship

Kaya, Hatice; Hany, Jürgen; Fastabend, Annemarie; Roth-Härer, Astrid; Winneke, Gerhard; Lilienthal, Hellmuth

doi:10.1006/taap.2001.9318

Cited by 104 publications

(61 citation statements)

References 70 publications

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“…Turyk et al (2006) found a negative association between PCB serum levels and SHBGbound testosterone in Great Lakes sport fish consumers. In rats, goats, and bulls, exposure to PCBs induced a decrease in serum testosterone levels (Machala et al, 1998;Kaya et al, 2002;Murugesan et al, 2005;Oskam et al, 2005). Rylander et al (2006) found no associations between serum PCB153 and testosterone concentrations in middle-aged and elderly men.…”

Section: Discussionmentioning

confidence: 97%

Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose–response relationships

Dhooge

Hond

Koppen

et al. 2009

J Expo Sci Environ Epidemiol

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Flanders is densely populated with much industry and intensive farming. Hormonal status of 14-to 15-year-old male adolescents was studied in relation to internal exposure to pollutants. A total of 887 participants were selected as a random sample of the adolescents residing in the study areas. Confounding factors and significant covariates were taken into account. Serum levels of testosterone, free testosterone and estradiol, and the aromatase index showed significant positive associations with serum levels of marker polychlorobiphenyls (sum of PCBs 138, 153, and 180) and of hexachlorobenzene (HCB) and a negative association with urinary cadmium concentration. Serum levels of estradiol also showed a positive association with serum levels of dichlorodiphenyldichloroethylene (DDE). A doubling of serum concentrations of marker PCBs and HCB and of urinary concentration of cadmium were, respectively, associated with an increase of 16.4% (Po0.00001) and 16.6% (Po0.001) and a decrease of 9.6% (Po0.001) in serum testosterone concentration. Similar findings were made after additional adjustment for concurrent exposures. Associations between biological effects and internal exposures were, in terms of the regression coefficient, often stronger at exposures below the median. Environmental exposures to pollutants resulting in ''normal'' levels of internal exposure were associated with quite substantial differences in hormone concentrations.

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Section: Discussionmentioning

confidence: 97%

Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose–response relationships

Dhooge

Hond

Koppen

et al. 2009

J Expo Sci Environ Epidemiol

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show abstract

“…There is a great deal of evidence that PCBs can result in abnormalities of gender-specific characteristics and disrupt sex hormone homeostasis in animals (Hany et al, 1999;Kaya et al, 2002). Some studies have concluded that sex hormone disruption might be one of causes of abnormal gender-specific characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the endocrine disrupting activities of PCBs have drawn considerable attention. In particular, a number of reports have demonstrated that PCBs can alter the sex steroid level and affect gonadal development in several species (Matta et al, 1998, Willingham et al, 2000Kaya et al, 2002). In the past few years, we have been studying endocrine disruption by PCBs using X. laevis.…”

Section: Introductionmentioning

confidence: 99%

Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis

Qin

Yang

et al. 2007

Aquatic Toxicology

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“…The PCBs have become widespread throughout China, and PCB pollution is very serious at some sites [6,7]. Therefore, we are concerned about the potential adverse effects of PCBs, especially considering the increasing number of reports demonstrating that PCBs, as endocrine disruptors, can alter sex steroid levels and influence gonadal development in several species [8][9][10]. Toxicities of PCBs might result in potentially ecotoxic effects on animal species.…”

Section: Introductionmentioning

confidence: 99%

Potential ecotoxic effects of polychlorinated biphenyls on Xenopus laevis

Qin

Zhou

Cong

et al. 2005

Enviro Toxic and Chemistry

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Abstract-We examined potential ecotoxic effects of polychlorinated biphenyl (PCB) 3 , PCB 5 , Aroclor 1254, and Aroclor 1242 on Xenopus laevis. Tadpoles were exposed to PCBs from stage 46/47 (system of Nieuwkoop and Faber) to the completion of metamorphosis. We demonstrated, to our knowledge for the first time, forelimb malformations caused by PCBs (malformation rate, Ͼ70%). The malformed forelimbs were fixed in the adduction-backward rotation position and could not move. Therefore, malformed male frogs were destined to have no offspring, because they could not grasp the females with their forelimbs to mate. Alcian bluealizarin red double-staining indicated that the forelimb malformation resulted from the shoulder abnormality. Compared with the normal shoulder joint, the proximal humerus with the humerus inter-rotated 90Њ in the abnormal shoulder joint. Moreover, testes from more than a third of male frogs with exposed to PCBs exhibited feminization to different degrees at gross morphology and histology, with fewer or abnormal spermatogonia and oocytes. Gonadal abnormalities would lead directly to reproductive dysfunction and population decline. These results suggest that PCBs have potentially ecotoxic effects on amphibian populations. We infer that PCBs could play roles in amphibian malformations and population declines, at least at sites that are polluted heavily with PCBs.

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Effects of Maternal Exposure to a Reconstituted Mixture of Polychlorinated Biphenyls on Sex-Dependent Behaviors and Steroid Hormone Concentrations in Rats: Dose–Response Relationship

Cited by 104 publications

References 70 publications

Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose–response relationships

Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose–response relationships

Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis

Potential ecotoxic effects of polychlorinated biphenyls on Xenopus laevis

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