Effects of MCI-186 (Edaravone), a Novel Free Radical Scavenger, Upon Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice

N-Acetylcysteine Reduces the Severity of Atherosclerosis in Apolipoprotein E-Deficient Mice by Reducing Superoxide Production

“…26,27 We had already demonstrated that MCI-186, a free radical scavenger, and olmesartan, an angiotensin type 1 receptor antagonist, suppress the severity of experimental atherosclerosis. 11 Indeed, angiotensin stimulation has been reported to produce free radicals from various cells. 28 Free radicals from vessel walls are thought to play a critical role in atherogenesis.…”

Atherosclerotic plaques induced by marble-burying behavior are stabilized by exercise training in experimental atherosclerosis

“…Four sections of 6 μm thickness were harvested per slide, and thus 8 slides per mouse were prepared. All sections were immersed for 15 s in 60% isopropanol, stained for 30 min in a saturated oil-red-O solution at room temperature, counterstained with hematoxylin, and then mounted under coverslips with glycerol gelatin [13,14]. Also, collagen contents were detected by Sirius red staining.…”

“…After being weaned at 4 weeks of age, mice were fed a normal chow diet (Oriental Yeast) until 6 weeks of age, when the animals were switched to a high fat diet containing 20% fat and 0.3% cholesterol as previously described [13,14].…”

Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein

“…Oxidative stress plays an important role in atherosclerosis. [16][17][18][19][20][21] Several studies have suggested that oxidative stress increases with age and compromises the function of the vascular wall cells. 1,2,[22][23][24] Our data suggest that the activation of mtMnSOD decreases with age and reduces the tolerance of vascular wall cells against oxLDL, which, in turn, could promote atherosclerotic diseases such as coronary artery disease.…”