Effects of MDMA exposure on the conditioned place preference produced by other drugs of abuse

Cole, Jon C.; Sumnall, Harry; O’Shea, Esther; Marsden, C.A.

doi:10.1007/s00213-002-1374-x

Cited by 58 publications

(37 citation statements)

References 44 publications

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“…The results of these studies are conflicting in that CPP to cocaine has been found to be enhanced (Fone et al, 2002;Horan et al, 2000), whereas CPP to amphetamine and heroin has been found to be unaffected (Cole et al, 2003) in rats previously treated with MDMA. However, treatment of rats with MDMA reduced formation of CPP to alcohol, an outcome that is similar to that observed for the formation of CPP to sex in this study.…”

Section: Discussionmentioning

confidence: 95%

Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.

Straiko¹,

Gudelsky²,

Coolen³

2007

Behavioral Neuroscience

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Among young adults, 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is a popular drug of abuse, and anecdotal evidence indicates that repeated use of MDMA may result in impairments in sexual function and decreased sex drive in human users. There has been little investigation of the effects of MDMA on sexual function in rodents. In the present study, the authors determined that in male rats (Rattus novegicus) tested in a sexually naïve or a sexually experienced state, administration of a serotonin (5-HT)-depleting regimen of MDMA did not produce a change in mount, intromission, and ejaculation latency or in mount and intromission frequency compared with such latency and frequency in vehicle-treated control rats. In contrast to vehicle-treated rats, MDMA-treated rats did not form a conditioned place preference (CPP) to sex. Failure of MDMA-treated rats to form CPP to sex may be due to MDMA-induced impairments in circuits mediating sexual reward.

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Section: Discussionmentioning

confidence: 95%

Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.

Straiko¹,

Gudelsky²,

Coolen³

2007

Behavioral Neuroscience

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“…Previous single-dose CPP investigations of MDMA/cocaine interactions have employed designs aimed at assessing the effects of prior MDMA exposure on cocaine CPP. Achat-Mendes et al (2003) observed that a single dose of MDMA produced longlasting effects on cocaine-induced reward, but in a similar paradigm Cole et al (2003) failed to find evidence of any effect of prior MDMA exposure on cocaine CPP. Of course, the limitation of such single dose pretreatment experiments is they do not permit characterization of the full dose-effect function for combined MDMA and cocaine CPP.…”

Section: Discussionmentioning

confidence: 99%

“…MDMA and cocaine, presented separately at low doses, have been shown to elicit CPP in rats (Bardo et al, 1995;Cole et al, 2003;Schechter, 1991). Interestingly, a purportedly neurotoxic dose of MDMA (20 mg/kg, s.c.) administered prior to MDMA CPP testing significantly decreased conditioning at lower doses of the test dose, but not at higher doses of the test dose (Schechter, 1991).…”

mentioning

confidence: 99%

The effects of concurrent administration of (±)3,4-Methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat

Diller

Rocha

Cardon

et al. 2007

Pharmacology Biochemistry and Behavior

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Conditioned place preference (CPP), a commonly used model for studying the role of contextual cues in drug reward and drug seeking, was employed to explore possible behavioral interactions between (±)3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") and cocaine. On each of four occasions, adult male rats received one of three doses of MDMA (0 mg/kg, 5 mg/kg, 10 mg/kg; administered subcutaneously [s.c.]) combined with one of three doses of cocaine (0 mg/kg, 2.5 mg/ kg, 5 mg/kg; administered intraperitoneally [i.p.]), and were then tested in a CPP paradigm. The results showed MDMA-induced CPP at a unit dose of 5 mg/kg, but at the 10 mg/kg dose there was a return to baseline (control) performance levels. For cocaine alone, CPP increased in a linear fashion as the drug dose was increased. Concurrent administration resulted in antagonism of each drug, but there was evidence that this pattern was reversible at higher doses of the respective drugs. These data are instructive insofar as they suggest that the behavioral and neurochemical effects of MDMA and cocaine presented in isolation are dramatically altered when the two drugs are presented in combination.

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“…Cornish et al 2003;Robledo et al 2004;Schenk et al 2003;Wakonigg et al 2004) and non-human primates (Beardsley et al 1986;Fantegrossi et al 2002;Fantegrossi et al 2004;Lamb and Griffith 1987;Lile et al 2005) suggest that animals will self-administer MDMA. Conditioned place preference, referring to the tendency to spend more time in a chamber associated with an i njection of the drug, was reported to occur in rats given MDMA (Bilsky et al 1990; Cole and Sumnall 2003;Meyer et al 2002). A study that examined the rapidity with which a drug-naive rat descended a runway to obtain an injection of MDMA also found that descent was more rapid when MDMA was available (Wakonigg et al 2004).…”

Section: Drug Dependence and Abuse Liabilitymentioning

confidence: 99%

Questions and Hypotheses

Black¹

2002

Understanding Social Science Research

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Effects of MDMA exposure on the conditioned place preference produced by other drugs of abuse

Abstract: MDMA pretreatment reduced the rewarding properties of ethanol. This finding may represent a functional consequence of MDMA-induced neurotoxicity. By extrapolation, human users of MDMA may be exposed to an increase in risks associated with alcohol abuse.

Cited by 58 publications

References 44 publications

Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.

Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.

The effects of concurrent administration of (±)3,4-Methylenedioxymethamphetamine and cocaine on conditioned place preference in the adult male rat

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