2004
DOI: 10.1038/sj.ejcn.1601985
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Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects

Abstract: Objective: To investigate the effect of a rye, high-fibre diet (HFD) vs a wheat, low-fibre diet (LFD), meal frequency, nibbling (Nib, seven times a day) or ordinary (Ord, three times a day), and their combined effects on blood glucose, insulin, lipids, urinary C-peptide and ileal excretion of energy, cholesterol and bile acids in humans. Design: LFD period with Nib or Ord meal frequency followed by an HFD diet with Nib or Ord meal frequency in randomized, crossover design. Setting: Outpatients of ileostomy vol… Show more

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Cited by 52 publications
(34 citation statements)
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“…In addition, wholegrain foods are generally less energydense than refined-grain foods due to the high fibre and water content (21,50) . Furthermore, the intake of wholegrain food may result in a delayed digestion and absorption of its starch and thus result in relatively lower postprandial insulin and glucose responses (22)(23)(24)51) . As high insulin levels may promote storage of metabolic substrates, a lower insulin response may result in the oxidation and lipolysis of fat rather than its storage (24) .…”
Section: Discussionmentioning
confidence: 99%
“…In addition, wholegrain foods are generally less energydense than refined-grain foods due to the high fibre and water content (21,50) . Furthermore, the intake of wholegrain food may result in a delayed digestion and absorption of its starch and thus result in relatively lower postprandial insulin and glucose responses (22)(23)(24)51) . As high insulin levels may promote storage of metabolic substrates, a lower insulin response may result in the oxidation and lipolysis of fat rather than its storage (24) .…”
Section: Discussionmentioning
confidence: 99%
“…In our study, free fatty acids were significantly raised from 4 th week until 32 nd week in experimental rats when compared with control. In another study, there were a significant raise in fatty acids in inflammatory bowel disease [17][18][19]. In conclusion, ulcerative colitis rats exhibit lower levels of TC and LDL-C compared to healthy subjects.…”
Section: Research Articlementioning
confidence: 81%
“…First, fiber increases stool weight and shortens the time of passage of gastric contents, thus reducing the time available for the digestion and absorption of nutrients [85,86]. Second, fiber has a direct effect on the regulation of glucose and insulin [87], and insulin is known to affect both lipid metabolism and appetite. Third, high-fiber foods, particularly fruits and vegetables, often contain phytoestrogens (isoflavones and lignans), the levels of which are inversely correlated with both abdominal obesity [88] and insulin resistance [89].…”
Section: Intake Of Nutrientsmentioning
confidence: 99%