Effects of Mechanical Insufflation-Exsufflation on the Breathing Pattern in Stable Subjects With Duchenne Muscular Dystrophy: A Step in a Wrong Direction

Toussaint, Michel; Gonçalves, Miguel R.; Chatwin, Michelle

doi:10.4187/respcare.06495

Cited by 2 publications

(2 citation statements)

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“…THRIVE has the advantage of increasing oxygen concentration, removing carbon dioxide from the ineffective chamber, and maintaining positive airway pressure, thus improving lung compliance and reducing upper airway obstruction [20]. However, in terms of upper airway obstruction, jet ventilation, which was developed in 1967, has the same enhanced oxygenation advantage as THRIVE, although they work in different ways [21, 22].…”

Section: Discussionmentioning

confidence: 99%

Supraglottic jet oxygenation and ventilation for obese patients under intravenous anesthesia during hysteroscopy: a randomized controlled clinical trial

et al. 2019

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Background Supraglottic jet oxygenation and ventilation (SJOV) can effectively maintain adequate oxygenation in patients with respiratory depression, even in apnea patients. However, there have been no randomized controlled clinical trials of SJOV in obese patients. This study investigated the efficacy and safety of SJOV using WEI Nasal Jet tube (WNJ) for obese patients who underwent hysteroscopy under intravenous anesthesia without endotracheal intubation. Methods A single-center, prospective, randomized controlled study was conducted. The obese patients receiving hysteroscopy under intravenous anesthesia were randomly divided into three groups: Control group maintaining oxygen supply via face masks (100% oxygen, flow at 6 L/min), the WNJ Oxygen Group with WNJ (100% oxygen, flow: 6 L/min) and the WNJ SJOV Group with SJOV via WNJ [Jet ventilator working parameters:100% oxygen supply, driving pressure (DP) 0.1 MPa, respiratory rate; (RR): 15 bpm, I/E; ratio 1:1.5]. SpO 2 , P ET CO 2 , BP, HR, ECG and BIS were continuously monitored during anesthesia. Two-Diameter Method was deployed to measure cross sectional area of the gastric antrum (CSA-GA) by ultrasound before and after SJOV in the WNJ SJOV Group. Episodes of SpO 2 less than 95%, P ET CO 2 less than 10 mmHg, depth of WNJ placement and measured CSA-GA before and after jet ventilation in the WNJ SJOV Group during the operation were recorded. The other adverse events were collected as well. Results A total of 102 patients were enrolled, with two patients excluded. Demographic characteristics were similar among the three groups. Compared with the Control Group, the incidence of P ET CO 2 < 10 mmHg, SpO 2 < 95% in the WNJ SJOV group dropped from 36 to 9% ( P = 0.009),from 33 to 6% ( P = 0.006) respectively,and the application rate of jaw-lift decreased from 33 to 3% ( P = 0.001), and the total percentage of adverse events decreased from 36 to 12% ( P = 0.004). Compared with the WNJ Oxygen Group, the use of SJOV via WNJ significantly decreased episodes of SpO 2 < 95% from 27 to 6% ( P = 0.023), P ET CO 2 < 10 mmHg from 33 to 9% ( P = 0.017), respectively. Depth of WNJ placement was about 12.34 cm in WNJ SJOV Group. There was no significantly difference of CSA-GA before and after SJOV in the WNJ SJOV Group ( P = 0.234). There were no obvious cases of nasal bleeding in all the three groups. Conclusions SJOV can effectively and safely maintain adequate oxygenati...

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Section: Discussionmentioning

confidence: 99%

Supraglottic jet oxygenation and ventilation for obese patients under intravenous anesthesia during hysteroscopy: a randomized controlled clinical trial

et al. 2019

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“…The use of mechanical insufflation-exsufflation is effective at increasing peak cough flow [91], but fatigue is significantly increased immediately after therapy [92]. The physiological effectiveness of mechanical insufflation-exsufflation remains to be elucidated with more work needed on its effect on breathing pattern and lung mechanics [93,94].…”

Section: Cough Assistancementioning

confidence: 99%

Highlights from the Respiratory Failure and Mechanical Ventilation 2020 Conference

et al. 2021

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The Respiratory Intensive Care Assembly of the European Respiratory Society organised the first Respiratory Failure and Mechanical Ventilation Conference in Berlin in February 2020. The conference covered acute and chronic respiratory failure in both adults and children. During this 3-day conference, patient selection, diagnostic strategies and treatment options were discussed by international experts. Lectures delivered during the event have been summarised by Early Career Members of the Assembly and take-home messages highlighted.

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Effects of Mechanical Insufflation-Exsufflation on the Breathing Pattern in Stable Subjects With Duchenne Muscular Dystrophy: A Step in a Wrong Direction

Cited by 2 publications

References 14 publications

Supraglottic jet oxygenation and ventilation for obese patients under intravenous anesthesia during hysteroscopy: a randomized controlled clinical trial

Supraglottic jet oxygenation and ventilation for obese patients under intravenous anesthesia during hysteroscopy: a randomized controlled clinical trial

Highlights from the Respiratory Failure and Mechanical Ventilation 2020 Conference

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