Effects of medial frontal cortex lesions on DRL performance in rats

Finger, Stanley; Altemus, Katharine L.; Green, Leonard; Wolf, Cynthia; Miller, Jonathan; Almli, C. Robert

doi:10.1016/0031-9384(87)90405-7

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…In contrast, delayed alternation and reversal learning tasks require the subject to generate different responses to the same stimuli from trial to trial. In the rat, the former tasks are impaired by ventral orbital lesions whereas the latter tasks are disrupted by medial PFC lesions (Eichenbaum, Clegg, & Feeley, 1983; Finger et al, 1987; Kolb, Nonneman, & Singh, 1974; Nalwa & Rao, 1985; Neill, 1976). Thus the ventral orbital region may be essential for simple response inhibition, whereas medial areas may play a role both in generating differential responses to familiar stimuli that change their association with reward from trial to trial and in suppressing responses to stimuli previously associated with reward.…”

Section: Discussionmentioning

confidence: 99%

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex.

Seamans¹,

Floresco²,

Phillips³

1995

Behavioral Neuroscience

306

269

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The effects of reversible lidocaine-induced lesions of 2 subregions of the rat medial prefrontal cortex (mPFC) were examined on a series of cognitively based foraging behaviors on a radial-arm maze. Lesions of the prelimbic (PL) or anterior cingulate (AC) cortex prior to the retention phase of a delayed-foraging task disrupted performance differentially; rats with PL lesions visited arms in a random manner, whereas rats with AC lesions revisited previously baited arms preferentially. Rats with AC lesions were also impaired on a single-trial foraging task; they made numerous revisits to previously baited arms. PL lesions had no effect on performance of this task in well-trained rats. However, rats trained on the 2-phase task did not adapt to a new foraging strategy after a PL lesions, when they were switched unexpectedly to the single-trial foraging task. These data demonstrate functional heterogeneity within the rat mPFC and suggest that the PL is involved in processes through which recently acquired information is used to organize and modify foraging behavior, whereas the AC may play an important role in response flexibility.

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Section: Discussionmentioning

confidence: 99%

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex.

Seamans¹,

Floresco²,

Phillips³

1995

Behavioral Neuroscience

306

269

View full text Add to dashboard Cite

show abstract

“…Several studies reported either a decreased reinforcement rate coupled with increased response rate while another demonstrated an increase in very short IRTs (Numan et al, 1975;Nalwa and Rao, 1985). However, several other studies failed to demonstrate an effect of medial frontal cortex lesions, although in one study the lesion may have spared the IL (Kolb et al, 1974;Finger et al, 1987). Several other studies with mPFC lesions that clearly appeared to spare the IL did not have an effect on DRL responding (Neill et al, 1974;Neill, 1976).…”

Section: Comparison Of Neurocircuitry Underlying 5-csrtt and Drl Behamentioning

confidence: 99%

The Utility of Impulsive Bias and Altered Decision Making as Predictors of Drug Efficacy and Target Selection: Rethinking Behavioral Screening for Antidepressant Drugs

Marek

Day

Hudzik

2015

Journal of Pharmacology and Experimental Therapeutics

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Cognitive dysfunction may be a core feature of major depressive disorder, including affective processing bias, abnormal response to negative feedback, changes in decision making, and increased impulsivity. Accordingly, a translational medicine paradigm predicts clinical action of novel antidepressants by examining drug-induced changes in affective processing bias. With some exceptions, these concepts have not been systematically applied to preclinical models to test new chemical entities. The purpose of this review is to examine whether an empirically derived behavioral screen for antidepressant drugs may screen for compounds, at least in part, by modulating an impulsive biasing of responding and altered decision making. The differential-reinforcement-of-low-rate (DRL) 72-second schedule is an operant schedule with a documented fidelity for discriminating antidepressant drugs from nonantidepressant drugs. However, a theoretical basis for this empirical relationship has been lacking. Therefore, this review will discuss whether response bias toward impulsive behavior may be a critical screening characteristic of DRL behavior requiring long interresponse times to obtain rewards. This review will compare and contrast DRL behavior with the five-choice serial reaction time task, a test specifically designed for assessing motoric impulsivity, with respect to psychopharmacological testing and the neural basis of distributed macrocircuits underlying these tasks. This comparison suggests that the existing empirical basis for the DRL 72-second schedule as a pharmacological screen for antidepressant drugs is complemented by a novel hypothesis that altering impulsive response bias for rodents trained on this operant schedule is a previously unrecognized theoretical cornerstone for this screening paradigm.

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Attention, Response Inhibition, and Activity Level in Children: Developmental Neuropsychological Perspectives

Halperin¹,

McKay²,

Matier³

et al. 1994

Advances in Child Neuropsychology

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Effects of medial frontal cortex lesions on DRL performance in rats

Cited by 10 publications

References 7 publications

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex.

Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex.

The Utility of Impulsive Bias and Altered Decision Making as Predictors of Drug Efficacy and Target Selection: Rethinking Behavioral Screening for Antidepressant Drugs

Attention, Response Inhibition, and Activity Level in Children: Developmental Neuropsychological Perspectives

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