Effects of medicagenic acid metabolites, originating from biotransformation of an Herniaria hirsuta extract, on calcium oxalate crystallization in vitro

Peeters, Laura; Foubert, Kenn; Schreurs, Gerd; Verhulst, Anja; Pieters, Luc; Hermans, Nina

doi:10.1016/j.jep.2021.114860

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Studies reported that saponins play an important role in preventing the formation of urinary stones [ 70 , 71 ]. The anti-crystallization property of saponins is due to their ability to act to inhibit crystal–cell interaction, which in turn reduces crystal retention in the urinary tract [ 72 ]. Moreover, it has been shown that this effect could be due to saponins showing a higher rate of ionization and Ca 2+ chelation, thereby increasing the solubility of CaOx crystals and finally decreasing the formation of urinary stones [ 73 ].…”

Section: Molecular Mechanism Of Bioactive Compounds Present In Medici...mentioning

confidence: 99%

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

et al. 2022

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Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as Argemone mexicana L., Berberis trifoliata Hartw. ex Lindl., Costus mexicanus Liebm, Chenopodium album L., Ammi visnaga (L.) Lam., Eysenhardtia polystachya (Ortega) Sarg., Selaginella lepidophylla (Hook. & Grev.) Spring, and Taraxacum officinale L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL.

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Section: Molecular Mechanism Of Bioactive Compounds Present In Medici...mentioning

confidence: 99%

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

et al. 2022

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Plant-based therapies for urolithiasis: a systematic review of clinical and preclinical studies

Allam,

Sabra

2024

Int Urol Nephrol

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Effect of methanolic extract of Mimosa malacophylla A.Gray in vero and HEK-293 cell lines, and in the morphology of kidney and bladder of rats with induced urolithiasis

Guillén-Meléndez

Soto‐Domínguez

Loera‐Arias

et al. 2022

Journal of Ethnopharmacology

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Effects of medicagenic acid metabolites, originating from biotransformation of an Herniaria hirsuta extract, on calcium oxalate crystallization in vitro

Cited by 4 publications

References 31 publications

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

Plants Used in Mexican Traditional Medicine for the Management of Urolithiasis: A Review of Preclinical Evidence, Bioactive Compounds, and Molecular Mechanisms

Plant-based therapies for urolithiasis: a systematic review of clinical and preclinical studies

Effect of methanolic extract of Mimosa malacophylla A.Gray in vero and HEK-293 cell lines, and in the morphology of kidney and bladder of rats with induced urolithiasis

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