Effects of medications on hypoxia‐inducible factor in the retina: A review

Kim, Angela H.; Kolesnikova, Masha; Ngo, Wei Kiong; Tsang, Stephen H.

doi:10.1111/ceo.14161

Cited by 10 publications

(5 citation statements)

References 139 publications

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“…The antioxidant mechanism of metformin has also been reported to include the diminution of reactive oxygen intermediates within the rod photoreceptor outer segments in response to light absorption [ 138 ]. Inhibition of hypoxia-inducible factor-1alpha via metformin has been hypothesized as a plausible novel therapy for retinal degenerative disease [ 139 ]. A possible association between metformin treatment and a lower risk of open-angle glaucoma among individuals with NIDDM has been suggested [ 140 , 141 ].…”

Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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“…The αKG can be produced from glutamate via oxidative deamination by glutamate dehydrogenase, where glutamate is a common amino donor [12]. In addition to oxygen partial pressure, αKG, iron ions, and ascorbic acid can modulate the activity of prolyl hydroxylase and hypoxia-inducible factor 1 (HIF-1) expression [13,14].…”

Section: Discussionmentioning

confidence: 99%

Ferrous Ascorbate as A Potential Biomarker for Diabetic Retinopathy: A Vitreous Humour Metabolomics Study

Liu,

Hui

et al. 2024

Preprint

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Background This study aimed to explore differences in vitreous humour metabolites and metabolic pathways between patients with and without diabetic retinopathy (DR) and identify potential metabolite biomarkers. Methods Clinical data and vitreous fluid samples were collected from 125 patients (40 without diabetes, 85 with DR). The metabolite profiles of the vitreous fluid samples were analysed using ultra-high performance liquid chromatography, Q-Exactive mass spectrometry, and multivariate statistical analysis. A machine learning model based on Least Absolute Shrinkage and Selection Operator Regularized logistic regression was used to build a risk scoring model based on selected metabolite levels. Candidate metabolites were regressed to glycated haemoglobin levels by a logistic regression model. Results Twenty differential metabolites were identified between the DR and control groups and were significantly enriched in five Kyoto Encyclopedia of Genes and Genomes pathways (arginine biosynthesis; tricarboxylic acid cycle; alanine, aspartate, and glutamate metabolism; tyrosine metabolism; and D-glutamate metabolism). Ferrous ascorbate was risk factor for glycaemic control. Conclusions Disorders in the metabolic pathways of arginine biosynthesis, tricarboxylic acid cycle, alanine, aspartate, glutamate metabolism, tyrosine metabolism, and D-glutamate metabolism were associated with DR. Risk scores based on vitreous fluid metabolites can be used for the diagnosis and management of DR. Ferrous ascorbate can provide insights into potential new pathogenic pathways for DR.

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“…The αKG can be produced from glutamate via oxidative deamination by glutamate dehydrogenase, where glutamate is a common amino donor [ 24 ]. In addition to oxygen partial pressure, αKG, iron ions, and ascorbic acid can modulate the activity of prolyl hydroxylase and hypoxia-inducible factor 1 (HIF-1) expression [ 25 , 26 ]. Our results revealed low levels of αKG, fumaric acid, and succinylacetone in patients with DR.…”

Section: Discussionmentioning

confidence: 99%

Ferrous ascorbate as a potential biomarker for diabetic retinopathy: a vitreous humour metabolomics study

Liu,

Hui

et al. 2024

BMC Ophthalmol

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Background This study aimed to explore differences in vitreous humour metabolites and metabolic pathways between patients with and without diabetic retinopathy (DR) and identify potential metabolite biomarkers. Methods Clinical data and vitreous fluid samples were collected from 125 patients (40 without diabetes, 85 with DR). The metabolite profiles of the vitreous fluid samples were analysed using ultra-high performance liquid chromatography, Q-Exactive mass spectrometry, and multivariate statistical analysis. A machine learning model based on Least Absolute Shrinkage and Selection Operator Regularized logistic regression was used to build a risk scoring model based on selected metabolite levels. Candidate metabolites were regressed to glycated haemoglobin levels by a logistic regression model. Results Twenty differential metabolites were identified between the DR and control groups and were significantly enriched in five Kyoto Encyclopedia of Genes and Genomes pathways (arginine biosynthesis; tricarboxylic acid cycle; alanine, aspartate, and glutamate metabolism; tyrosine metabolism; and D-glutamate metabolism). Ferrous ascorbate significantly contributes to poorer glycaemic control outcomes, offering insights into potential new pathogenic pathways in DR. Conclusions Disorders in the metabolic pathways of arginine biosynthesis, tricarboxylic acid cycle, alanine, aspartate, glutamate metabolism, tyrosine metabolism, and D-glutamate metabolism were associated with DR. Risk scores based on vitreous fluid metabolites can be used for the diagnosis and management of DR. Ferrous ascorbate can provide insights into potential new pathogenic pathways for DR.

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Effects of medications on hypoxia‐inducible factor in the retina: A review

Cited by 10 publications

References 139 publications

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Ferrous Ascorbate as A Potential Biomarker for Diabetic Retinopathy: A Vitreous Humour Metabolomics Study

Ferrous ascorbate as a potential biomarker for diabetic retinopathy: a vitreous humour metabolomics study

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