Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats

Idris, Sherifat Banke; Folorunsho, Ambali Suleiman; Mohammed, Bisalla; Musa, Suleiman Mohammed; Charles, Onukak; Olusegun, Ayo Joseph

doi:10.12980/apjtb.4.2014c55

Cited by 9 publications

(10 citation statements)

References 22 publications

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“…During the past few years, the functional role of melatonin in improving cognitive function has been reported . A variety of studies have demonstrated that melatonin can ameliorate cognitive impairment caused by total sleep deprivation, pesticide exposure, diabetes mellitus, and even irradiation injury . Electrophysiological studies also suggest that melatonin is a potent regulator involved in the processes of memory formation, LTP, synaptic transmission, and neuronal plasticity in the hippocampus and other brain regions .…”

Section: Introductionmentioning

confidence: 99%

“…17,18 A variety of studies have demonstrated that melatonin can ameliorate cognitive impairment caused by total sleep deprivation, pesticide exposure, diabetes mellitus, and even irradiation injury. [19][20][21][22] Electrophysiological studies also suggest that melatonin is a potent regulator involved in the processes of memory formation, LTP, synaptic transmission, and neuronal plasticity in the hippocampus and other brain regions. [23][24][25][26] Melatonin can have neuro-protective effects on cognitive function by depressing oxidative stress and activating the molecular machinery related to oxidative modulation.…”

Section: Introductionmentioning

confidence: 99%

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Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2‐ARE signaling activity

Chen

Renn

Liao

et al. 2017

Journal of Pineal Research

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Prolonged exposure to gamma-hydroxybutyric acid (GHB) would cause drug intoxication in which impaired cognitive function results from enhanced hippocampal oxidative stress may serve as a major symptom in this deficiency. Considering melatonin possesses significant anti-oxidative efficacy, this study aimed to determine whether melatonin would successfully promote the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) signaling, depress oxidative stress, and rescue hippocampal bioenergetics and cognitive function following drug intoxication injury. Adolescent rats subjected to 10 days of GHB were received melatonin at doses of either 10 or 100 mg/kg. Time-of-flight secondary ion mass spectrometry, biochemical assay, quantitative histochemistry, [ C]-2-deoxyglucose analysis, together with Morris water maze were employed to detect the molecular signaling, oxidative status, bioenergetic level, as well as the cognitive performances, respectively. Results indicated that in GHB-intoxicated rats, enhanced oxidative stress, increased cholesterol level, and decreased anti-oxidative enzymes activities were detected in hippocampal regions. Intense oxidative stress paralleled well with reduced bioenergetics and poor performance in behavioral testing. However, in rats treated with melatonin following GHB intoxication, all above parameters and cognitive function were gradually returned to nearly normal levels. Melatonin also remarkably promoted the translocation of Nrf2 from cytoplasm to nucleus in a dose-dependent manner, thereby increased the Nrf2-ARE signaling-related downstream anti-oxidative enzymes activities. As melatonin effectively rescues hippocampal bioenergetics through depressing the oxidative stress by promoting Nrf2-ARE molecular machinery, this study thus highlights for the first time that clinical use of melatonin may serve as a therapeutic strategy to improve the cognitive function in unsuspecting victims suffered from GHB intoxication injury.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2‐ARE signaling activity

Chen

Renn

Liao

et al. 2017

Journal of Pineal Research

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“…Male rats exposed to sipermetrin in different doses have increased malondialdehyde (MDA) content in the brain, heart, liver, kidneys and testes. 22 A study by Banke et al (2014) showed that MDA concentrations in the brain increased after exposure to a mixture of sipermethrin and clorfirifos for 12 weeks. 23 Malondialdehyde (MDA) is a lipid peroxidation product resulting from the reaction of oxygen radicals with polyunsaturated fatty acid residues in phospholipid membrane, and shows the presence of protein and DNA damage.…”

Section: Effect Of 17-estradiol Level On Uterine Mda Levelmentioning

confidence: 99%

“…22 A study by Banke et al (2014) showed that MDA concentrations in the brain increased after exposure to a mixture of sipermethrin and clorfirifos for 12 weeks. 23 Malondialdehyde (MDA) is a lipid peroxidation product resulting from the reaction of oxygen radicals with polyunsaturated fatty acid residues in phospholipid membrane, and shows the presence of protein and DNA damage. 23 The main source of MDA in biological samples is the peroxidation of polyunsaturated fatty acids with two or more methylene double binds.…”

Section: Effect Of 17-estradiol Level On Uterine Mda Levelmentioning

confidence: 99%

Effect of per oral sipermetrin exposure on serum 17-beta estradiol and uterine malondialdehyde (MDA) levels in female Wistar strain rats (Rattus norvegicus)

Widowati

Sujuti

Mintaroem

2018

MOG

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Objective: This study aimed to verify the effect of oral siper-metrin exposure to decrease serum estradiol 17b levels and increased malondialdehyde (MDA) in the uterus level of female Wistar strain rats (Rattus norvegicus).Materials and Methods: The method of this study was true experimental post test only control group in vivo using 24 female rats, divided into 3 groups treated by administering a dose of 5, 10 and 20 mg/kg sipermetrin for 28 days and one control group. Then blood samples were taken from the heart for measurement of serum estradiol 17b levels by ELISA and uterine organs were taken for measurement of Malondialdehyde (MDA) with spectro-photometry method.Results: The results of the measurement of serum estradiol 17b and uterus malondialdehyde (MDA) levels of female Wistar strain rats (Rattus norvegicus) showed an opposite pattern, where there was a decline in serum estradiol 17b levels and an increase in uterus malondialdehyde (MDA) level. There was a significant difference (p=0.000<alpha) in 17b estradiol serum and uterus Malondialdehyde (MDA) levels of female rats between control group and group exposed to sipermetrin treatment for 28 days.Conclusions: Oral sipermetrin exposure can decrease serum levels of estradiol 17b and increase uterine levels of malondi-aldehyde (MDA) of female Wistar strain rats (Rattus norvegicus).

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“…Consequently, the combination of these chemicals exhibits a different toxicological profile compared with toxicity of the pesticides singly (Babu et al, 2010). Although combination of pesticides is beneficial in combating pest resistance, this combination poses a new challenge since the resultant effects of such interactions are unknown (Banke et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Deleterious Effect of Chlorpyrifos and Cypermethrin on Oxidative Stress Enzymes and Biochemical Indices of Male Albino Rats

Ikp¹,

Ude²,

Ok³

2015

J. of Medical Sciences

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This study was carried out to evaluate the effects of chlorpyrifos and cypermethrin, singly and in combination on oxidative stress enzymes and biochemical indices of male albino rats. 35 male albino rats weighing 170-200 g were divided into seven groups (A-G) of five rats each in a Completely Randomized Design. Rats in group A served as the control and received feed and distilled water only. Groups B and C received 5 and 10 mg of chlorpyrifos; groups D and E received 5 and 10 mg of cypermethrin, while groups F and G received 5 and 10 mg of combination (chlorpyrifos+cypermethrin), respectively. Treatment was administered via oral gavage and lasted for 65 days. At the end of treatment, the rats were sacrificed and blood samples were analyzed for oxidative stress enzymes and biochemical indices. On the one hand, result obtained for oxidative stress enzymes revealed that pesticide treatment significantly (p<0.05) reduced the levels of superoxide dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT) activity and increased lipid peroxidation (MDA) level in rats treated with chlorpyrifos only. On the other hand, result for biochemical indices revealed that aspartate transaminase (AST) increased significantly (p<0.05) in the group of rats treated with 10 mg of chlorpyrifos and 5 mg of cypermethrin and reduced in those treated with 5 mg of chlorpyrifos and 10 mg of cypermethrin. Alkaline phosphatase (ALP) level reduced significantly in all the groups except for the group that received 5 mg of chlorpyrifos. While, alkaline transaminase (ALT) level increased significantly in some treated rats especially in the group that received 10 mg of the combination. Present findings therefore demonstrate that chlorpyrifos and cypermethrin could induce oxidative stress and alter the levels of some liver marker enzymes in male rats.

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Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats

Abstract: Cognitive deficits elicited by CPF and CYP was mitigated by melatonin due to its antioxidant property.

Cited by 9 publications

References 22 publications

Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2‐ARE signaling activity

Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2‐ARE signaling activity

Effect of per oral sipermetrin exposure on serum 17-beta estradiol and uterine malondialdehyde (MDA) levels in female Wistar strain rats (Rattus norvegicus)

Deleterious Effect of Chlorpyrifos and Cypermethrin on Oxidative Stress Enzymes and Biochemical Indices of Male Albino Rats

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