Effects of melatonin on partial unilateral ureteral obstruction induced oxidative injury in rat kidney

Atılgan, Doğan; Parlaktaş, Bekir Süha; Uluocak, Nıhat; Erdemır, Fikret; Fırat, Fatih; Erkorkmaz, Ünal; Saylan, Oguzhan

doi:10.4103/0974-7796.95552

Cited by 15 publications

(14 citation statements)

References 26 publications

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“…Research showed that diminished antioxidant expression and increased levels of ROS in obstructed kidneys were primarily responsible for tubulointerstitial injury and fibrogenesis [24]. ROS have been shown to damage proteins, lipids, nucleic acids, carbohydrates, and other molecules, resulting in the development of inflammation, apoptosis, fibrosis, and cell proliferation [9]. In addition, research demonstrated that ROS caused severe injury of the cell membrane by lipid peroxidation reactions and contributed to tubulointerstitial damage and fibrosis in rat models of PUUO.…”

Section: Discussionmentioning

confidence: 99%

“…Known factors in the pathophysiology of renal obstructive parenchymal injury include renal blood flow impairment, intrapelvic pressure elevation, and vasoactive and inflammatory mediators [6–8]. Recently, it has been suggested that reactive oxygen species (ROS), which are formed during ureteral obstruction, may play a role in this process [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction

Öztürk

Fırat

Tekçe

et al. 2017

The Kaohsiung J of Med Scie

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To evaluate the effects of nicorandil in a rat kidney model of partial unilateral ureteral obstruction (PUUO). Thirty male rats were randomly divided into three groups as follows: (1) Group 1 (Sham-control), ureters of the rats were manipulated but not ligated; (2) Group 2 (PUUO-untreated), PUUO was performed with two-thirds of the left ureter embedded in the psoas muscle; and (3) Group 3 (PUUO-nicorandil treated). After PUUO was established, nicorandil (15 mg/kg/day) was administered by gastric lavage for 21 days to determine its effects on PUUO-induced histopathological-, functional-, and oxidative stress-induced changes. The serum levels of blood urea nitrogen and creatinine were reduced in Group 3. The level of urinary albumin and the ratio of urinary protein/creatinine were increased in the kidneys of Group 2 but decreased in Group 3. Malondialdehyde value was decreased in Group 3 compared with Group 2. Antioxidant enzyme activities (catalase, superoxide dismutase, and glutathione peroxidase) were decreased in Group 2. Nicorandil treatment caused an increase in these enzyme activities. In Group 3, leukocyte infiltration and tubular dilatation were significantly reduced. Other parameters, such as degeneration of tubular epithelium and fibrosis, also showed a marked improvement in Group 3. Expression of inducible nitric oxide synthase in Group 2 and expression of endothelial nitric oxide synthase in Group 3 were significantly elevated. Nicorandil can inhibit renal tubular damage and tubulointerstitial fibrosis by reducing the effects of oxidative stress after PUUO.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction

Öztürk

Fırat

Tekçe

et al. 2017

The Kaohsiung J of Med Scie

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“…Membrane lipid peroxidation may generate reactive carbonyl compounds such as MDA, one of the reliable indicators of ROS-induced I/R tissue damage. 25 MDA is the most abundant aldehyde resulting from lipid peroxidation. 26 Among various antioxidant systems equipped within aerobic cells, the key antioxidant enzymes (SOD, GSH) are major mechanisms to reduce local levels of ROS.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidney

et al. 2012

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Objective: To investigate the protective effect of infliximab on ischemia-reperfusion (I/R) injury of the rat kidney. Methods: Twenty-eight male Wistar albino rats were divided into four groups: sham-operated, I/R, I/R with infliximab administered before ischemia [I/R þ infliximab (bi)], and I/R with infliximab administered before reperfusion [I/R þ infliximab (br)]. After a right nephrectomy to produce damage, the left renal vessels were occluded for 60 min, followed by 24-h reperfusion in rats. Changes in the rat kidney were observed by measuring the tissue levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) and by evaluating hematoxylin-eosin (H&E)-stained and periodic acid-Schiff (PAS) sections. Results: The MDA and MPO levels in the I/R group were significantly higher than in the other groups (p < 0.05), and the SOD and GSH levels in the I/R þ infliximab (bi) and I/R þ infliximab (br) groups were significantly higher than in the I/R group (p < 0.05). However, histological examination revealed that the I/R þ infliximab (bi) group and the I/R þ infliximab (br) group had significantly fewer tubular changes and interstitial inflammatory cell infiltration than the I/R group. Conclusion: These results show that infliximab may protect against I/R injury in the rat I/R model.

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“…Obstructive uropathy is a common problem in daily clinical urology practice and can occur anywhere along the urinary tract (14). Upper urinary tract obstruction is most often secondary to calculi, strictures, tumors and ureteropelvic junction or ureterovesical junction obstruction and is usually a reversible and partial unilateral condition (4).…”

Section: Discussionmentioning

confidence: 99%

“…Upper urinary tract obstruction is most often secondary to calculi, strictures, tumors and ureteropelvic junction or ureterovesical junction obstruction and is usually a reversible and partial unilateral condition (4). Although ureteral obstructions may cause kidney parenchymal damage due to several mechanisms, the exact pathophysiological mechanism of the changes in UPUO has not been fully understood (3,14). Intrarenal collecting system pressure elevation, renal blood flow impairment, vasoactive and inflammatory mediators are some of the known factors in pathophysiology of renal damage arising from UPUO (3, 4).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of partial unilateral ureteral obstruction-induced renal damage with hyperbaric oxygen therapy in a rat model

Sancak¹,

Tan²,

Türkön³

et al. 2017

European Urology Supplements

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ARTICLE INFO ______________________________________________________________ ______________________Objective: The objective of the present study was to evaluate the effectiveness of HBO therapy on biochemical parameters, renal morphology and renal scintigraphy in rats undergoing chronic unilateral partial ureteral obstruction (UPUO). Material and methods: Thirty-five rats were divided into five equal groups: Control group; Sham group; HBO group; UPUO group and UPUO/HBO group. The effects of HBO therapy were examined using biochemical parameters and histopathological changes. After calculating the score for each histopathological change, the total histopathological score was obtained by adding all the scores. In addition, dynamic renal scintigraphy findings were evaluated. Results: Serum parameters indicating inflammation, serum tumor necrosis factoralpha, ischemia modified-albumin, IMA/albumin ratio and Pentraxin-3 levels, were observed to be high in the UPUO group and low in the UPUO/HBO treatment group. Similarly, in the treatment group, the reduction in malondialdehyde, total oxidant status and oxidative stress index levels and increase in total antioxidant capacity values were observed to be statistically significant compared to the UPUO group (p<0.001, p=0.007, p<0.001, p=0.001, respectively). The total score and apoptosis index significantly decreased after administration of HBO treatment. Dynamic 99mTc-MAG3 renal scintigraphy also showed convincing evidence regarding the protective nature of HBO against kidney injury. In the UPUO/HBO therapy group, the percentage contribution of each operated kidney increased significantly compared to the UPUO group (41.73% versus 32.72%). Conclusion:The findings of this study indicate that HBO therapy had a reno-protective effect by reducing inflammation and oxidative stress, and preserving renal function after renal tissue damage due to induction of UPUO.

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Effects of melatonin on partial unilateral ureteral obstruction induced oxidative injury in rat kidney

Cited by 15 publications

References 26 publications

Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction

Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction

Protective Effect of Infliximab on Ischemia/Reperfusion-Induced Damage in Rat Kidney

Attenuation of partial unilateral ureteral obstruction-induced renal damage with hyperbaric oxygen therapy in a rat model

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