Effects of Melissa officinalis on anxiety and sleep quality in patients undergoing coronary artery bypass surgery: A double-blind randomized placebo controlled trial

Soltanpour, Alireza; Alijaniha, Fatemeh; Naseri, Mohsen; Kazemnejad, Anoshirvan; Heidari, Mohammad Reza

doi:10.1016/j.eujim.2019.01.010

Cited by 29 publications

(29 citation statements)

References 39 publications

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“…The clinical trial was conducted on 80 patients, and all patients were given herbal drugs (500 mg of M. officinalis leaves) while the placebo control group was given 500 mg of wheat starch three times a day. The Oxidative Medicine and Cellular Longevity results of seven days of treatment with M. officinalis reduced the level of anxiety (49%) and improved the sleep quality (54%) in patients after coronary artery bypass surgery [128].…”

Section: Clinical Studiesmentioning

confidence: 99%

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Medicinal plants are being used worldwide for centuries for their beneficial properties. Some of the most popular medicinal plants belong to the Melissa genus, and different health beneficial effects have already been identified for this genus. Among these species, in particular, the Melissa officinalis L. has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and also flatulence inhibiting effects. The beneficial properties of the Melissa officinalis, also known as “lemon balm herb”, can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant. In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of M. officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health-promoting effects and possible perspective nutraceutical applications. To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

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Section: Clinical Studiesmentioning

confidence: 99%

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…41,42 In human randomized controlled trials (RCTs), lemon balm has demonstrated the ability to alleviate a series of neuropsychiatric symptoms, predominantly centered around depression and anxiety. Based on these trials, lemon balm interventions exerted the ability to reduce anxiety, depression, 43 insomnia, [44][45][46][47] postpartum depression, 48 anxiety induced palpitations, 49 anxiety in cardiovascular disease patients, 50 and healthy participants. 51 (Table 2) Akhoundzadeh et al, 52 inspired by the efficacy of lemon balm in treating amnesia, evaluated its effectiveness in Alzheimer's disease and cognitive disorders, revealing potential benefits.…”

Section: Discussionmentioning

confidence: 99%

Historical Course of Neuropsychiatric Effects of Lemon Balm (Melissa Officinalis L.) as a Medicinal Herb

Ghazizadeh¹,

Mohammadinasab²,

Travica³

et al. 2021

Pharm Sci

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Affective disorders have become prevalent and costly worldwide chronic conditions. Lemon Balm (Melissa Officinalis L.) is a medicinal plant with beneficial effects on neuropsychiatric disorders. Its potential to specifically treat conditions such as depression and anxiety has been investigated for over 20 centuries. Given the lack of a historical overview of lemon balm in mood disorders, the present review aimed to introduce the historical course of the neuro-psychiatric applications of lemon balm across the centuries. We investigated several viable medieval Arabic sources up to the 15th century, to distinguish the neuropsychiatric applications, especially anxiolytic and anti-depressive effects of lemon balm. In the early centuries, lemon balm was mainly prescribed to treat gastrointestinal disorders. Over time, physicians identified the efficient use of lemon balm in sadness, sleep disorders, anxiety, depression, epilepsy, ischemic stroke, amnesia, sciatalgia, and radicular neuropathy. Importantly, it was established that the therapeutic effects of lemon balm in the field of neuro-psychiatric diseases were emphasized by physicians during the Middle Ages. These findings have since been validated in human clinical trials. Lemon balm has also demonstrated the ability to be utilized in epilepsy, amnesia and ischemic stroke. Based on the extensive history of lemon balm in neuropsychiatry, future investigations could use this knowledge to extensively investigate the potential of lemon balm in neuropsychiatric disorders such as depression and anxiety, and possibly develop an efficient neuropsychiatric remedy.

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“…Soltanpour and colleagues studied the effects of M. officinalis dried leaf powder on quality of sleep and in relieving anxiety in a randomized, double-blind, placebo-controlled study [ 115 ]. Eighty volunteer in-patients who were undergoing coronary artery bypass surgery were given 500 mg capsules of M. officinalis dried leaf powder three times a day (morning, noon, and before sleep) for seven days.…”

Section: Efficacy and Safety Of Botanical Nootropicsmentioning

confidence: 99%

The Safety and Efficacy of Botanicals with Nootropic Effects

Roe

Venkataraman

2021

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: Recent estimates for the global brain health supplement category, i.e. nootropic market size, will grow to nearly $5.8 billion by 2023. Overall, nearly one-quarter (23%) of adults currently take a supplement to maintain or improve brain health or delay and reverse dementia. Not surprisingly, the use of such supplements increases with age – more than one-third of the oldest generation (ages 74 and older) takes a supplement for brain health. This widespread use is being driven by a strong desire both in the younger and older generations to enhance cognitive performance and achieve healthy aging. The most prevalent botanicals currently dominating the nootropic marketplace include Gingko biloba, American ginseng, and Bacopa monnieri. However, other botanicals that affect stress, focus, attention, and sleep have also been procured by dietary supplement companies developing products for improving both, short and long-term brain health. This review focuses on efficacy data for neuroactive botanicals targeted at improving cognitive function, stress reduction, memory, mood, attention, concentration, focus, and alertness, including Bacopa monnieri, Ginkgo biloba, Holy basil, American ginseng, Gotu kola, Lemon balm, Common and Spanish sages and spearmint. Botanicals are discussed in terms of available clinical efficacy data and current safety profiles. Data gaps are highlighted for both efficacy and safety to bring attention to unmet needs and future research.

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Effects of Melissa officinalis on anxiety and sleep quality in patients undergoing coronary artery bypass surgery: A double-blind randomized placebo controlled trial

Cited by 29 publications

References 39 publications

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Historical Course of Neuropsychiatric Effects of Lemon Balm (Melissa Officinalis L.) as a Medicinal Herb

The Safety and Efficacy of Botanicals with Nootropic Effects

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