Effects of menstrual cycle and urinary tract instrumentation on uroflowmetry

Visco, Anthony G.; Cholhan, Hilary J.; O'Toole, Laurie; Guzick, David S.

doi:10.1002/(sici)1520-6777(2000)19:2<147::aid-nau5>3.0.co;2-c

Cited by 11 publications

(9 citation statements)

References 15 publications

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“…Van Geelen et al 10 determined that there was a prolongation of the urethral functional profile length (UFPL) in the midportion of the menstrual cycle, whereas other investigators identified no significant changes in the urodynamic variables during the menstrual cycle. [11][12][13][14] Gitsh and Brandstetter 15 described an increased bladder tone during the follicular phase and a decreased tone during the luteal phase of the menstrual cycle in humans, compared with the other phases. On the basis of data collected via a questionnaire, 16 a limited association of urinary incontinence with the menstrual cycle, including the menstruation itself, was identified among a population of female humans with regular menstrual cycles, indicating a borderline significant moderate increase in urinary incontinence near the time of ovulation.…”

mentioning

confidence: 99%

Influence of the estrous cycle on urodynamic and morphometric measurements of the lower portion of the urogenital tract in dogs

Hamaide¹,

Verstegen²,

Snaps³

et al. 2005

ajvr

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confidence: 99%

Influence of the estrous cycle on urodynamic and morphometric measurements of the lower portion of the urogenital tract in dogs

Hamaide¹,

Verstegen²,

Snaps³

et al. 2005

ajvr

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“…This is because the estrous cycle exerts no significant effect on micturition functions in female rats under normal conditions (18). Similarly, uroflowmetry in women is not affected by the menstrual cycle (36). Therefore, on the basis of these findings, we supposed that the estrus phase exerted little effect on urethral smooth muscle activity in our study.…”

Section: Effects Of 8-oh-dpat (03 Mg/kg Iv) and Way-100635 (01 Mg/kmentioning

confidence: 64%

Does pharmacological activation of 5-HT_1A receptors improve urine flow rate in female rats?

Chen

Hsieh

Fan

et al. 2016

American Journal of Physiology-Renal Physiology

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Chen SC, Hsieh TH, Fan WJ, Lai CH, Peng CW. Does pharmacological activation of 5-HT1A receptors improve urine flow rate in female rats? Am J Physiol Renal Physiol 311: F166 -F175, 2016. First published May 4, 2016 doi:10.1152/ajprenal.00469.2015.-The role of 5-HT1A receptors in regulating voiding functions remains unclear, particularly regarding the urine flow rate (UFR) during voiding. This study examined the effects of 5-HT1A receptors on regulating urethral functions in female rats and investigated underlying modulatory mechanisms. Intravesical pressure (IVP), external urethral sphincterelectromyography (EUS-EMG), and UFR were simultaneously recorded during continuous transvesical infusion to examine the effects of a 5-HT1A receptor agonist (8-OH-DPAT) and antagonist (WAY-100635) on bladder and urethral functions. In addition, this study evaluated the independent roles of urethral striated and smooth muscles in the UFR in rats after a neuromuscular blockade (NMB) treatment and bilateral hypogastric nerve transection. Our results revealed that 8-OH-DPAT significantly increased the maximal UFR but reduced the mean UFR. This discrepancy may be because 8-OH-DPAT markedly increased the maximal UFR during the initial segment of the flow duration and subsequently induced an approximately zero level of long oscillatory waves during the remaining flow duration. Thus the mean UFR was reduced because of the prolonged approximately zero level of the UFR. However, paralyzing the EUS with an NMB agent, 8-OH-DPAT, significantly increased the maximal and mean UFRs because the prolonged zero level of the oscillatory UFR did not continue. These results support the hypothesis that the increased UFR in female rats during voiding is due to the induction of urethral smooth muscle relaxation by 8-OH-DPAT. This paper provides a detailed understanding of the role of 5-HT 1A receptors in controlling the UFR in female rats. intravesical pressure; EUS-EMG; 8-OH-DPAT; WAY-100635; neuromuscular blockade THE PRIMARY FUNCTIONS OF THE lower urinary tract (LUT) are storage and periodic urine elimination. These functions require reciprocal coordination between the urinary bladder and urethra outlets, including the bladder neck, urethra, and external urethral sphincter (EUS). The urethra consists of smooth and striated muscle layers that are regulated by the following three peripheral nerve sets: sacral parasympathetic (pelvic nerves) and thoracolumbar sympathetic nerves (hypogastric nerves) that innervate urethral smooth muscles, and sacral somatic nerves (pudendal nerves) that innervate urethral striated muscles including the EUS and pelvic floor muscles.Receptors for serotonin [5-hydroxytryptamine (5-HT)] comprise 14 structurally different 5-HT receptors in mammalian species, including 7 subfamilies (5-HT 1 -5-HT 7 ) (28). Pharmacological studies in animals have indicated that the three sets of LUT nerve terminals contain numerous 5-HT receptor subfamilies. Specifically, 5-HT 1A receptors are vital to LUT functions (32). The effects of 5-HT...

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“…Int Urogynecol J Pelvic Floor Dysfunct 1996;7:5). 2,7,[15][16][17] There are only three studies that considered asymptomatic older women. One investigation included 40 women with a mean age of 75 years, but all were institutionalized, and many had significant comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Establishing a Mean Postvoid Residual Volume in Asymptomatic Perimenopausal and Postmenopausal Women

Gehrich

Stany

Fischer

et al. 2007

Obstetrics &Amp; Gynecology

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Most asymptomatic perimenopausal and postmenopausal women had a PVR volume less than 50 mL, which was unaffected by multiple factors that were thought to potentially affect bladder function. Establishing "normal" volumes in this population may aid in developing recommendations regarding appropriate bladder function and retention criteria for women who are symptomatic or those who have had pelvic floor surgery.

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Effects of menstrual cycle and urinary tract instrumentation on uroflowmetry

Cited by 11 publications

References 15 publications

Influence of the estrous cycle on urodynamic and morphometric measurements of the lower portion of the urogenital tract in dogs

Influence of the estrous cycle on urodynamic and morphometric measurements of the lower portion of the urogenital tract in dogs

Does pharmacological activation of 5-HT_1A receptors improve urine flow rate in female rats?

Establishing a Mean Postvoid Residual Volume in Asymptomatic Perimenopausal and Postmenopausal Women

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