Effects of mental stress on brachial artery flow-mediated vasodilation in healthy normal individuals

Harris, Craig; Edwards, Jennifer; Baruch, Amy L.; Riley, Ward A.; Pusser, Benjamin E.; Rejeski, W. Jack; Herrington, David M.

doi:10.1016/s0002-8703(00)90083-8

Cited by 65 publications

(82 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although no blood tests were performed, as invasiveness may have resulted in further stimulation of the SNS distorting the results, these findings support the view that adrenaline release in response to mental stress may have produced both vasodilatation and an increase in CI. Vasodilator response to mental stress was confirmed by Harris et al, who reported an increase in brachial arterial diameter with mental stress as compared to that without mental stress (4). In the present study also, vasodilatation is reflected by decrease in TPR with mental stress, facilitating oxygen delivery to tissues.…”

Section: Discussionsupporting

confidence: 86%

“…Such association increases the likelihood of subsequent fatal and nonfatal cardiac events (3). Mental stress can activate the sympathetic nervous system (SNS) and results in increased heart rate (HR) and blood pressure (BP), creating extra myocardial oxygen consumption and demand (4,5). An increase in the double product is directly related to mental stress (6); in patients with coronary artery disease, the maximum work load that can be managed by the myocardium is reduced and it is likely that this critical level will be exceeded by mental stress or mild exercise, which may precipitate angina (7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of mental stress on cardiovascular function at rest and after ingestion of fructose or sucralose in healthy, white European males

Memon¹,

Macdonald²,

Bennett³

2013

Turk J Med Sci

View full text Add to dashboard Cite

Spectrophotometric determination of Ni(II) was carried out using picolinaldehyde-4-phenyl-3-thiosemicarbazone (PAPT) as a complexing/chromogenic reagent. The possibility of using a micellar system was explored to enhance the degree of detection and allow a more sensitive spectrophotometric method for the determination of nickel ions. The anionic surfactant Triton X-100 greatly enhanced the molar absorptivity and limit of detection relative to that observed with bulk water or an organic solvent. The linear calibration graphs were obtained for 0.5-2.0 mg L −1 and 0.001-1.0 mg L −1 of Ni(II) in aqueous and surfactant media, respectively. Using this approach, the limit of detection for the PAPT-Ni(II) complex (based on 3 σ of blank absorbance/slope) was found to be 0.0008 mg L −1 with a micellar enhancement reagent. The interference from over 50 cations, anions, and complexing agents was studied at 0.50 mg L −1 of Ni(II); most metal ions can be tolerated in considerable amounts in aqueous micellar solutions.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effect of mental stress on cardiovascular function at rest and after ingestion of fructose or sucralose in healthy, white European males

Memon¹,

Macdonald²,

Bennett³

2013

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Some evidence suggests that FMD might also be impaired in apparently healthy subjects during an acute stress that elevates sympathetic nervous system activity (SNA) (18,24,35). However, these findings are not universal (17) and might depend on the nature of the stress and the experimental design. Lind et al (24) concluded that acute increases in SNA with mental arithmetic and cold pressor tests impaired FMD when expressed relative to blood flow stimulus.…”

mentioning

confidence: 99%

Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery

Dyson

Shoemaker²,

Hughson

2006

American Journal of Physiology-Heart and Circulatory Physiology

104

106

View full text Add to dashboard Cite

son. Effect of acute sympathetic nervous system activation on flowmediated dilation of brachial artery. Am J Physiol Heart Circ Physiol 290: H1446 -H1453, 2006. First published November 11, 2005 doi:10.1152/ajpheart.00771.2005.-We tested the hypothesis that flow-mediated dilation (FMD) of the brachial artery would be impaired by acute increases in sympathetic nervous system activity (SNA) in models where similar peak shear stress stimulus was achieved by varying the duration of forearm muscle ischemia. Eleven healthy young men were studied under four different conditions, each with its own control: lower body suction (LBS), cold pressor test (CPT), mental arithmetic task (MAT), and activation of muscle chemoreflex (MCR). The duration of ischemia before observation of FMD by ultrasound imaging was 5 min each for control, LBS, and CPT; 3 min for MAT; and 2-min for MCR. Peak shear rate was not different between control and any of the SNA conditions, although total shear in the first minute was reduced in MAT. MCR was the only condition in which brachial artery vasoconstriction was observed before forearm occlusion [4.38 (SD 0.53) vs. control 4.60 (SD 0.53) mm, P Ͻ 0.05]; however, diameter increased to the same absolute value as that of the control, so the percent FMD was greater for MCR . During SNA, the increase in plasma cortisol from baseline was significant only for MCR; the increase in plasma norepinephrine was significant for MCR, LBS, and CPT; and the increase in epinephrine was significant only for MCR. These results showed that the four models employed to achieve increases in SNA had different effects on baseline brachial artery diameter and that blunted FMD is not a general response to increased SNA. endothelium; shear stress; muscle chemoreflex; cold pressor test; mental stress FLOW-MEDIATED DILATION (FMD) is studied by high-resolution ultrasound imaging of the change in conduit artery vessel dimension in response to a sudden increase in blood flow after release of circulatory occlusion. When compared with that in healthy, young subjects, FMD is impaired in patients with coronary artery disease (27, 40), as well as essential (11, 28) and white-coat (13) hypertension. Reduced FMD reflects impaired endothelial function, which has been found to be an independent risk factor of coronary artery disease (6, 12). Some evidence suggests that FMD might also be impaired in apparently healthy subjects during an acute stress that elevates sympathetic nervous system activity (SNA) (18,24,35). However, these findings are not universal (17) and might depend on the nature of the stress and the experimental design. Lind et al. (24) concluded that acute increases in SNA with mental arithmetic and cold pressor tests impaired FMD when expressed relative to blood flow stimulus. Impaired FMD was also found during application of lower body suction (18), but a different study (17) of a mental arithmetic challenge reported enhanced FMD. Unfortunately, the magnitude of reactive hyperemia or shear stress was not measured in thi...

show abstract

“…Este efeito contrapõe o efeito vasoconstrictor direto. Em indivíduos com doença arterial coronariana, a lesão endotelial impede esses eventos 27 . A associação do estresse mental com eventos arrítmicos relaciona-se com a hiperatividade simpática e uma redução da atividade parassimpática, além da presença de isquemia 28 .…”

unclassified

“…Nos pacientes que apresentam disfunção do ventrículo esquerdo (diminuição da fração de ejeção maior ou igual a 5%), durante o teste de estresse mental, há um aumento maior da freqüência cardíaca, débito cardíaco, pressão arterial e resistência vascular periférica, quando comparados com aqueles que não desenvolveram disfunção de ventrículo esquerdo durante o estresse 27,30 . Há portanto uma correlação com o aumento da secreção de epinefrina 31 .…”

unclassified

Estresse Mental e Sistema Cardiovascular

Loures¹,

Sant'anna²,

Baldotto³

et al. 2002

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

AtualizaçãoO estresse mental ou emocional é um dos maiores problemas das sociedades modernas. Em uma situação de estresse, o organismo humano redistribui suas fontes de energia, antecipando uma agressão iminente. Esse mecanismo de adaptação é vantajoso se realmente houver perigo iminente. Entretanto, se esse estado persistir por muito tempo, o dano será inevitável.A cultura popular há muito associa o estresse agudo e crônico com o desenvolvimento de doenças, corroborado por inúmeros estudos epidemiológicos e experimentais, que demonstram uma ligação entre o estresse mental e o aparecimento e curso de muitas doenças, desde simples infecções virais, até úlceras gástricas e neoplasias. O sistema cardiovascular possui ampla participação na adaptação ao estresse, sofrendo por isso as conseqüências da sua exacerbação. A suspeita de que estados de estresse mental agudos e crônicos sejam fatores de risco para maior morbimortalidade por doença cardiovascular é antiga. Entretanto, a adequada comprovação científica deste fato somente vem sendo obtida mais recentemente. Muitos profissionais ainda encaram com certo ceticismo esta associação, encontrando dificuldade em valorizá-la na prática clínica, embora o estresse mental seja uma das principais queixas de pacientes.Alterações fisiológicas produzidas pelo estresse mental -A vida consiste de um equilíbrio dinâmico, constantemente alternando estados de estresse e homeostase. Desta forma, as forças que alteram a homeostase são equilibradas por respostas adaptativas geradas pelo organismo. Os organismos multicelulares se adaptam a essas situações através de complexas alterações neurais, humorais e celulares, envolvendo múltiplos órgãos e tecidos. O organismo humano desenvolveu um sistema complexo, constituído por componentes do sistema nervoso central, incluindo os neurônios do núcleo paraventricular hipotalâmico, que produzem o hormônio de liberação da corticotrofina, núcleos noradrenérgicos do tronco cerebral com seus componentes periféricos, o eixo hipotálamo-hipófise-adrenal e o sistema nervoso autônomo, cuja principal função é manter a homeostase no repouso e em situações de estresse. Este sistema exerce importante influência em muitas funções vitais, como a respiração, o tônus cardiovascular e o metabolismo intermediário, que também são alteradas por estados de estresse.Os fundamentos para o atual interesse envolvendo as conseqüências fisiopatológicas do estresse provêm dos achados de Cannon, que descreveu a reação de luta ou fuga, caracterizada por intensa descarga adrenérgica na presença de uma ameaça. Mais tarde, Seyle descreveu uma resposta mais generalizada, marcada pela ativação do eixo hipotálamo-hipofisário-adrenal 1 . Atualmente, as pesquisas se focalizam na importância da interpretação subjetiva do estresse e em suas repercussões nos diversos sistemas de forma aguda e crônica.O sistema cardiovascular participa ativamente das adaptações ao estresse (quadro I), estando portanto sujeito às influências neuro-humorais. As respostas cardiovasculares resultam principa...

show abstract

Effects of mental stress on brachial artery flow-mediated vasodilation in healthy normal individuals

Cited by 65 publications

References 51 publications

Effect of mental stress on cardiovascular function at rest and after ingestion of fructose or sucralose in healthy, white European males

Effect of mental stress on cardiovascular function at rest and after ingestion of fructose or sucralose in healthy, white European males

Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery

Estresse Mental e Sistema Cardiovascular

Contact Info

Product

Resources

About