Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice

Prevalence and Predictors of Patient Nonadherence to Pharmacological Acute Pain Therapy at Home After Day Surgery: A Prospective Cohort Study

“…beliefs and preferences may influence the patient's perceptions of the pharmacological treatment and the motivation to start and continue with it. 14 Analgesic non-adherence in patients with chronic pain is a frequent problem and a wellstudied topic in literature. 13,15,16 In contrast, analgesic non-adherence in patients with acute pain is not well studied.…”

“…12 Furthermore, the National Institute for Health and Clinical Excellence (NICE) guidelines pose that "adherence presumes an agreement between prescriber and patient about the prescriber's recommendations". 13,14 There are many causes of non-adherence but they fall into two overlapping categories: intentional and unintentional. 14 Unintentional non-adherence occurs when the patient intends to follow the agreed treatment but is prevented from doing so by barriers that are beyond his or her control.…”

“…Intentional non-adherence occurs when the patient decides not to follow the treatment recommendations. 14…”

Metamizole versus ibuprofen at home after day surgery: study protocol for a randomised controlled trial

“…The molecular mechanism of analgesic and antipyretic action of metamizole however, is still not fully understood. Metamizole is a prodrug and its activity is due to its immediate conversion to its active metabolites [ 37 ]. Several mechanisms were proposed, including the involvement of endogenous opioids and COX-1/COX-2 inhibition by dipyrone and its metabolites [ 38 , 39 ].…”

Polynuclear ampyrone based 3d coordination clusters

“…[22][23][24][25][26][27][28] Ampyrone, also known as 4-aminoantipyrine, is a pyrazole derivative that has a keto group at position 5 and is substituted at position 4 by an amino group (A, Scheme 1). This organic scaffold has been used for the synthesis of dihydrotestosterone products, 29 whilst its derivatives, exhibit cycotoxic, 30 antimicrobial 31 or anagesic 32 activity, similar bioactivity to ampicillin and streptomycin, 33 and has been used to produce redox active Ru CCs, 34 hydrogen bonded framewoks, 35 fluorescent chemo sensors for F -36 and Cu 2+ /F -37 recognition, selective probes for Al 3+ and cysteine detection, 38 and pigments. 39 Additionally, due to the presence of the amino and keto groups ampyrone can react with another organic scaffold that bears an aldehyde/ketone or amino group, yielding Schiff base ligands with multiple donor sites, which in turn can be excellent candidates for the construction of polynuclear CCs.…”