Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs

Monteiro, Eduardo Raposo; Figueroa, Christian D N; Choma, Jeison C; Campagnol, Daniela; Bettini, Carlos Maia

doi:10.1111/j.1467-2995.2008.00412.x

Cited by 86 publications

(113 citation statements)

References 21 publications

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“…The results of this investigation agree with previous studies that ACP-opioid combinations enhance the degree of sedation provided by ACP alone (MONTEIRO et al, 2008;MONTEIRO et al, 2009). According to this study, sedation was similar or slightly greater, and duration of this effect was longer, when ACP was administered in combination with morphine than with meperidine or fentanyl.…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, these drugs are generally administered in combination with opioid analgesics, and this combination has been named neuroleptanalgesia. When phenothiazine-opioid combinations are used, synergism seems to occur and sedation and analgesia appears to be greater with the combination than when each drug is administered alone (SMITH et al, 2001;MONTEIRO et al, 2008;MONTEIRO et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs

et al. 2011

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs

et al. 2011

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“…The blocking of dopamine receptors in the chemoreceptor trigger zone of the spinal cord depletes catecholamines in the thermoregulatory center of the hypothalamus leading to a loss of temperature control (LEMKE, 2007). Corroborating, Guedes et al (2007) and Monteiro et al (2008) reported a reduction in body temperature in dogs after administration of morphine and methadone; however, they attributed this to dyspnea, which was not observed in this study.…”

Section: Resultscontrasting

confidence: 49%

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Cintra

Duque

Silveira

et al. 2017

SCA

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Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomyEfeitos cardiorrespiratórios e eletrocardiográficos da metadona ou morfina no período perioperatório em cães anestesiados com infusão contínua de propofol e submetidos a ovário-histerectomia AbstractThe aims of this study were compare the electrocardiogram (ECG) and cardiopulmonary effects of methadone or morphine, both injected intravenously (IV) in dogs anesthetized with continuous infusion of propofol. Sixteen healthy female mongrel dogs were used in this study for elective ovariohysterectomy. The animals were allocated in random order into two groups assigned GME (methadone 0.3 mg kg -1 , IV) or GMO (morphine 0.3 mg kg -1 , IV). Parameters were evaluated: heart rate (HR), P-wave amplitude (Ps and PmV), interval between Ps and R waves (PR), QRS duration (QRS), R-wave amplitude (R), duration the interval between the Q and T waves (QT), systolic blood pressure (SBP), rectal temperature (RT), respiratory rate (RR), end tidal of carbon dioxide (ETCO 2 ) and periferic oxyhemoglobin saturation (SpO 2 ). Postoperative analgesia was assessed by mechanical nociceptive stimulus based on the scale proposed by Firth and Haldane (1999) and rescue analgesia based on the visual analogue scale. HR was lower in GME in relation to GMO. The P, PmV, PR, QRS, R and QT values remained within their normality tracks, showing no clinical importance. Apnea and ETCO 2 increased in both groups. There was no difference between groups of the analgesic effects. It can be concluded that methadone and morphine promote similar cardiovascular effects after IV injection during surgery in dogs anesthetized with propofol by continuous rate infusion, however, when methadone used, assisted ventilation is required. In addition, both drugs promote postoperative analgesia until six hours. ResumoO presente estudo teve como objetivo comparar as alterações no eletrocardiograma (ECG) e nos parâmetros cardiorrespiratórios da metadona ou morfina administrada pela via intravenosa (I.V.) em cães anestesiados com infusão intravenosa contínua de propofol. Foram utilizados 16 cadelas, sem raça definida submetidos ao procedimento de ovário-histerectomia. Os animais foram distribuídos aleatoriamente em dois grupos, designados como GME (metadona 0,3 mg kg -1 , I.V.) ou GMO (morfina 0,3 mg kg -1 , I.V.). Os parâmetros avaliados foram frequência cardíaca (FC), tempo e amplitude da onda P (Ps e PmV), intervalo entre as ondas P e R (PR), duração do complexo QRS (QRS), amplitude da onda R (R), duração do intervalo entre as ondas Q e T (QT), pressão arterial sistólica (PAS), temperatura retal (TR), frequência respiratória (f), tensão de dióxido de carbono no final da expiração (ETCO 2 ) e saturação de oxigênio na hemoglobina (SpO 2 ). A analgesia pós-operatória foi verificada seguindo a proposta de Firth e Haldane (1999) e o regaste analgésico baseado na escala análoga v...

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“…Among the dogs from group M, 33.3% exhibited bradycardia, which was also observed in 16.7% of dogs from group AM, corroborating the results of MENEGUETI et al (2014), who found bradycardia in 37.5% of animals after methadone was administered at the same dose used in the present study. MONTEIRO et al (2008) observed bradycardia in 16.7% of animals that received methadone only (0.5mgkg -1 ) and in 50% of Table 1 -Mean values and standard deviations of electrocardiographic and systolic blood pressure parameters in healthy dogs subjected to different sedation protocols. Systolic blood pressure (SBP) (mmHg), heart rate (HR) in beats per minute (BPM), P-wave amplitude (P amp) (mV), R-wave amplitude (mV), T-wave amplitude (mV), P-wave duration (P larg) (ms), PR interval (ms), QRS complex duration (ms),and QT interval (ms).…”

Section: Resultsmentioning

confidence: 99%

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

et al. 2016

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The present study aimed to evaluate the effects of different sedation protocols on blood pressure and echocardiographic and electrocardiographic parameters in dogs. In total, 24 male mixed-breed dogs with a mean weight of 9.87±3.0kg were used.Animals were randomly divided into four groups (n=6), which were subjected to sedation using the following protocols: acepromazine (0.05mgkg -1 ) and butorphanol (0.3mgkg -1

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Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs

Cited by 86 publications

References 21 publications

Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs

Comparison of the sedative effects of morphine, meperidine or fentanyl, in combination with acepromazine, in dogs

Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy

Electrocardiographic, echocardiographic, and indirect blood pressure evaluation in dogs subjected to different sedation protocols

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