Effects of methomyl on steroidogenic gene transcription of the hypothalamic-pituitary-gonad-liver axis in male tilapia

Meng, Shunlong; Qiu, Liping; Hu, Gengdong; Fan, Limin; Song, Chao; Zheng, Yao; Wu, Wei; Jianhong, Qu; Li, Dandan; Chen, Jiazhang; Xu, Pao

doi:10.1016/j.chemosphere.2016.09.024

Cited by 22 publications

(18 citation statements)

References 63 publications

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“…EE 2 is found in the lower ng/L level in aquatic water, but it is enough to cause sustainable impacts on reproduction and population evolution in fish . And the ability of methomyl binding to estrogen receptor was also found in our former research …”

Section: Introductionsupporting

confidence: 60%

Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus ) and recovery pattern

Meng

Qiu²,

Hu³

et al. 2017

Environmental Toxicology

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Tilapia were exposed to sub-lethal concentrations of 0, 0.2, 2, 20 or 200 μg/L for 30 days, then transferred to methomyl-free water for 18 days. E , T, 11-KTand VTG in serum were examined. There were no significant changes in all the parameters in serum of tilapia exposed to 0.2 μg/L and 2 μg/L methomyl compared to the control. However, 20 μg/L and 200 μg/L have the potential to disrupt the endocrine system of male tilapia, as shown by its ability to increase VTG and E and decrease T and 11-KT in serum. Thus it would appear the no observed adverse effect level for sexual steroid hormones of methomyl is lower than 2 μg/L. Recovery data showed that the effects produced by 20μg/L were reversible but not at 200μg/L. Furthermore, the sensitivity of above parameters to methomyl followed the order of VTG>E >11-KT>T>GSI, suggesting VTG being the better biomarkers.

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Section: Introductionsupporting

confidence: 60%

Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus ) and recovery pattern

Meng

Qiu²,

Hu³

et al. 2017

Environmental Toxicology

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“…Several studies have demonstrated that higher concentrations of methomyl might be responsible for the disruption of the endocrine system and expression of the LHR, StAR, 3β-HSD, and ARα genes in testes and the LHβ gene in the pituitary. Meng et al [38] reported significantly reduced expressions of these genes at higher methomyl concentrations. Hazardous effects of methomyl have also been studied in frogs and toads as virulence testers and representatives of amphibians [39,45,46].…”

Section: Toxicological Effects Of Methomyl Insecticidesmentioning

confidence: 97%

Current Approaches to and Future Perspectives on Methomyl Degradation in Contaminated Soil/Water Environments

et al. 2020

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Methomyl is a broad-spectrum oxime carbamate commonly used to control arthropods, nematodes, flies, and crop pests. However, extensive use of this pesticide in agricultural practices has led to environmental toxicity and human health issues. Oxidation, incineration, adsorption, and microbial degradation methods have been developed to remove insecticidal residues from soil/water environments. Compared with physicochemical methods, biodegradation is considered to be a cost-effective and ecofriendly approach to the removal of pesticide residues. Therefore, micro-organisms have become a key component of the degradation and detoxification of methomyl through catabolic pathways and genetic determinants. Several species of methomyl-degrading bacteria have been isolated and characterized, including Paracoccus, Pseudomonas, Aminobacter, Flavobacterium, Alcaligenes, Bacillus, Serratia, Novosphingobium, and Trametes. The degradation pathways of methomyl and the fate of several metabolites have been investigated. Further in-depth studies based on molecular biology and genetics are needed to elaborate their role in the evolution of novel catabolic pathways and the microbial degradation of methomyl. In this review, we highlight the mechanism of microbial degradation of methomyl along with metabolic pathways and genes/enzymes of different genera.

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“…E-EDCs can lead to disruption of the sex steroid hormone system through binding to the steroid hormone receptor or affecting its release, pathways, and function [ 35 ]. Reproductive-related gene expression analysis progressively enhanced a better understanding of the mechanistic action of these chemicals and give the ability to assess the different mode of actions for various compounds as well [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple Xenosteroid Pollutants Biomarker Changes in Cultured Nile Tilapia Using Wastewater Effluents as Their Primary Water Source

Zahran

Elmetwally

Awadin

et al. 2020

Animals

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This study was undertaken to screen levels of xenosteroids (estrogenic endocrine disrupting chemicals/E-EDCs) in Nile tilapia (Oreochromis niloticus) fish farms subjected to water fill from the drain at three sites S1 (highly polluted), S2 (moderately polluted), and a putative reference site (RS). Biometric, hormonal, gene expression, and histopathological analysis were investigated. Testosterone, progesterone, and zeranol residues were detected at (0.12–3.44 µg/L) in water samples of different sites. Bisphenol-A (BPA) exhibited a very high concentration (6.5 µg/mL) in water samples from S1. Testosterone, 17β-estradiol residues were detected in fish tissues from all sites at (0.16–3.8 µg/Kg) and (1.05–5.01 µg/Kg), respectively. BPA residues were detected at a very high concentration in the liver and muscle of fish collected from S1 at higher levels of 25.9 and 48.07 µg/Kg, respectively. The detected E-EDCs, at different sites, particularly BPA, reduced the somatic and testicular growth among sites and oversampling time points. Meanwhile, hepatosomatic index (HSI) was significantly increased in S1 compared to S2. All analyzed genes estrogen receptor-type I (er-I, er-ɑ) and II (er-II, er-ß1), polypeptide 1a (cyp19a1), SRY-box containing gene 9 (sox9), and vitellogenin (vtg) and gonadotropin hormones (luteinizing hormone (LH), follicle-stimulating hormone (FSH)), testosterone, 17β-estradiol, and anti-Mullerian hormone (AMH) were significantly expressed at S1 compared to other sites. Histopathology was more evident in S1 than other sites. These findings warrant immediate strategies development to control aquatic pollution and maintain fish welfare and aquaculture sustainability.

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Effects of methomyl on steroidogenic gene transcription of the hypothalamic-pituitary-gonad-liver axis in male tilapia

Cited by 22 publications

References 63 publications

Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus ) and recovery pattern

Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus ) and recovery pattern

Current Approaches to and Future Perspectives on Methomyl Degradation in Contaminated Soil/Water Environments

Multiple Xenosteroid Pollutants Biomarker Changes in Cultured Nile Tilapia Using Wastewater Effluents as Their Primary Water Source

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