Effects of Methylglyoxal on Central and Peripheral Cholinergic Responses

Davies, Mark; Chambers, P. L.; Rowan, Michael J.

doi:10.1007/978-3-642-71248-7_5

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Therefore, an important future direction will be to define the evolution of the relationship between MG and GABA A receptors in other species. It is possible that MG acts at GABA A receptors in invertebrates; application of 10–150 μM MG had an excitatory effect on the sixth abdominal ganglion of the cockroach (Davies et al, 1986). Although GABA is an inhibitory neurotransmitter in insects, it is also excitatory in some cell types (Beg and Jorgensen, 2003; Gisselmann et al, 2004).…”

Section: Future Directionsmentioning

confidence: 99%

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights

Distler¹,

Palmer²

2012

Front. Gene.

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Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis that induces protein modification (advanced glycation end-products, AGEs), oxidative stress, and apoptosis. The concentration of MG is elevated under high-glucose conditions, such as diabetes. As such, GLO1 and MG have been implicated in the pathogenesis of diabetic complications. Recently, findings have linked GLO1 to numerous behavioral phenotypes, including psychiatric diseases (anxiety, depression, schizophrenia, and autism) and pain. This review highlights GLO1's association with behavioral phenotypes, describes recent discoveries that have elucidated the underlying mechanisms, and identifies opportunities for future research.

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Section: Future Directionsmentioning

confidence: 99%

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights

Distler¹,

Palmer²

2012

Front. Gene.

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“…MG accumulates during hyperglycemia (Beisswenger et al, 2001;Lapolla et al, 2003), and it has been suggested that this accumulation may contribute to the development of diabetic neuropathy. Indeed, several investigations have demonstrated that MG induces apoptosis in rat Schwann cells (Fukunaga et al, 2004), adrenaline secretion in the peripheral nervous systems (Davies et al, 1986), and an increase intracellular Ca 2+ concentration ([Ca 2+ ] i ) in the human neuroblastoma cells (Kuhla et al, 2006). Therefore, we hypothesized that TRPA1-chan-nel activation by MG could be a cause of diabetic neuropathic pain.…”

Section: Introductionmentioning

confidence: 97%

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

et al. 2012

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-Methylglyoxal (MG) is an endogenous carbonyl compound that is produced in large quantity under hyperglycemic conditions, which are believed to contribute to the development of diabetic neuropathy. However, the mechanism by which this occurs and the molecular targets of MG are unclear.In the present study, we investigated the effect of MG on transient receptor potential ankyrin 1 (TRPA1) activation in human TRPA1-expressing HEK293 cells. MG activated TRPA1-expressing HEK293 cells, but failed to activate human capsaicin-sensitive transient receptor potential vanilloid 1 (TRPV1)-expressing HEK293 cells or mock-transfected HEK293 cells. MG also induced calcium (Ca 2+ ) influx in a concentration-dependent manner, and the concentration-response curve indicates that the effect of MG has an EC 50 of 343.1 ± 17.3 μM. Interestingly, the time course in the intracellular Ca 2+ concentration ([Ca 2+ ] i ) in human TRPA1-expressing HEK293 showed considerable differences in response to MG and cinnamaldehyde. Furthermore, we examined four endogenous carbonyl compounds, including MG, glyceraldehyde, glycolaldehyde, and glyoxal; only MG notably activated TRPA1-expressing HEK293 cells. These results may provide insight into the TRPA1-mediated effects of MG on diabetic neuropathy.

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Effects of methylglyoxal on adrenergic transmission in isolated rabbit intestine

Rowan

Davies

1991

Toxicology in Vitro

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Effects of Methylglyoxal on Central and Peripheral Cholinergic Responses

Cited by 7 publications

References 6 publications

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights

Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

Effects of methylglyoxal on adrenergic transmission in isolated rabbit intestine

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