Effects of metoclopramide and tropisetron on aldosterone secretion possibly due to agonism and antagonism at the 5-HT4 receptor

Sommers, De K.; Snyman, J. R.; Wyk, M. Van

doi:10.1007/s002280050125

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…The drug has effects at multiple receptor subtypes however, and those with lesser affinity will be important where high local concentrations are obtained. Primarily a DA-2 and 5HT2 (serotonin) receptor antagonist [10][11][12] , metoclopramide has lesser effects as a DA-1 (dopamine), alpha-2 and 5HT-3 antagonist 10,[13][14][15] , as well as being a 5HT-1 and 5HT-4 partial agonist [16][17][18] . With high metoclopramide concentrations and an intact vascular endothelium, DA-1, DA-2 and alpha-2 receptor effects will promote a minor degree of vasoconstriction 10,19 , the latter two acting indirectly via modulation of peripheral noradrenergic pathways.…”

Section: Discussionmentioning

confidence: 99%

Intra-arterial Injection of Metoclopramide, Midazolam, Propofol and Pethidine

2002

Anaesth Intensive Care

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A case is reported in which metoclopramide, midazolam, propofol, and pethidine were injected arterially during the course of anaesthesia, resulting in oedema and discolouration of the hand initially, but no long-term sequelae. An AVI 470 pump (3M Corporation) was used to control the infusion, and prevented backflow through a cannula which was unintentionally sited in an artery rather than a vein. Few anaesthetic drugs have their effects well documented when given arterially, and in particular, there were no previous reported cases involving metoclopramide in this context. The pharmacology of metoclopramide is discussed with reference to the drug's known effects on vascular beds and platelet function.

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Section: Discussionmentioning

confidence: 99%

Intra-arterial Injection of Metoclopramide, Midazolam, Propofol and Pethidine

2002

Anaesth Intensive Care

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5-Hydroxytryptamine receptors in the human cardiovascular system

Kaumann

Levy

2006

Pharmacology & Therapeutics

262

208

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Effect of naloxone on intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy

et al. 2016

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This study aims to evaluate the effect of naloxone on intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy under total intravenous anesthesia.A total of 90 patients, who underwent intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy under total intravenous anesthesia, were included into this study. All patients were randomly divided into 3 groups (each group, n=30): naloxone group (naloxone+fentanyl), tropisetron group (tropisetron+fentanyl), and fentanyl group (fentanyl). Patients in each group were given a corresponding dose of naloxone. Postoperative analgesia effect and the incidence of side effects such as nausea and vomiting were observed.Small doses of naloxone or tropisetron combined with fentanyl used for intravenous patient-controlled analgesia can significantly reduce the incidence of nausea and vomiting. Six hours after surgery, visual analogue scale (VAS) scores were significantly lower in patients that underwent intravenous patient-controlled analgesia using low-dose naloxone combined with fentanyl compared with patients who received fentanyl alone; however, the postoperative analgesic effect of tropisetron was not observed. Compared with the combination of tropisetron and fentanyl, low-dose naloxone combined with fentanyl can obviously reduce the incidence of nausea and vomiting in patients who underwent intravenous patient-controlled analgesia after laparoscopic cholecystectomy, and enhance the analgesic effect of fentanyl 6 hours after surgery.Low-dose naloxone can reduce the incidence of nausea and vomiting in patients who underwent laparoscopic cholecystectomy under total intravenous anesthesia, and exhibits a certain synergic analgesic effect.

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Effects of metoclopramide and tropisetron on aldosterone secretion possibly due to agonism and antagonism at the 5-HT4 receptor

Cited by 5 publications

References 14 publications

Intra-arterial Injection of Metoclopramide, Midazolam, Propofol and Pethidine

Intra-arterial Injection of Metoclopramide, Midazolam, Propofol and Pethidine

5-Hydroxytryptamine receptors in the human cardiovascular system

Effect of naloxone on intravenous fentanyl patient-controlled analgesia after laparoscopic cholecystectomy

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