Effects of Micronutrients on Metal Toxicity

Peraza, Marjorie A.; Ayala-Fierro, Felix; Barber, David S.; Casarez, Elizabeth; Rael, Leonard T.

doi:10.2307/3433921

Cited by 109 publications

(95 citation statements)

References 71 publications

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“…Hence, calcium insufficiency could intensify the harmful effects of lead on child growth, as gastrointestinal lead absorption is the major pathway of its uptake. 33 We found that blood lead levels during late pregnancy affected postnatal growth at 24 months. The early programming of postnatal growth caused by intrauterine exposure to lead may result from the separate influence of maternal blood lead levels either during the early or late gestational period.…”

Section: Figurementioning

confidence: 82%

Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake

Hong¹,

Kulkarni

Lim

et al. 2014

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT:Lead is an ubiquitous environmental pollutant, and no safe threshold for blood lead level in children has been discovered yet. Prenatal lead exposure affects growth of children.WHAT THIS STUDY ADDS: Low level of prenatal lead exposure of ,5.0 mg/dL affects postnatal children' s growth, which was further intensified by low calcium intake. abstract BACKGROUND: The effects on postnatal growth of maternal exposure to low levels of lead during pregnancy have not been well established. In addition, information is limited regarding the protective effect of dietary calcium intake during pregnancy against the effect of lead for fetal and postnatal growth. We investigated the relationship between prenatal exposure to lead and growth at birth and 6, 12, and 24 months postnatal, and evaluated the role of calcium intake against the effect of lead. METHODS:A total of 1150 pregnant women, and their subsequent offspring, enrolled in a prospective birth cohort study (Mothers and Children' s Environmental Health Study), were evaluated. Multivariable regression analysis was conducted to estimate the effects of prenatal maternal blood lead levels on growth at each follow-up. RESULTS:The blood lead levels of participating mothers were ,5.0 mg/dL and mean levels were 1.25 mg/dL during the early (before 20 gestational weeks) and late (at delivery) gestational periods. Prenatal exposure to lead, particularly in late pregnancy, was significantly associated with a reduction in infantile growth at 24 months. When pregnant women had dietary calcium intake at mean or upper level, the association was not significant. In contrast, lower than mean level of calcium intake intensified the adverse effect of prenatal lead exposure on growth in children.CONCLUSIONS: Prenatal lead exposure ,5.0 mg/dL adversely affects postnatal growth and low calcium intake aggravates the effect, indicating more stringent control of lead and sufficient intake of calcium are necessary to help children' s health.

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Section: Figurementioning

confidence: 82%

Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake

Hong¹,

Kulkarni

Lim

et al. 2014

Pediatrics

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“…Fruit was the third most energy source in their diet and provided important micronutrients. A protective effect of fruit against mercury contamination, via phytochemicals able to interact with the absorption, excretion and transport of toxic metals, has been postulated (Peraza et al, 1998). Fruit supplies vitamins C and E that possess anti-oxidant properties and may neutralize the toxic effects of mercury (Jacob-Ferreira et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Fishing activity, health characteristics and mercury exposure of Amerindian women living alongside the Beni River (Amazonian Bolivia)

Bénéfice

Luna-Monrroy

Lopez-Rodriguez

2010

International Journal of Hygiene and Environmental Health

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Populations in Bolivian Amazonia are exposed to mercury contamination through fish ingestion. A group of 170 Amerindian women living along the banks of the Beni River were examined in order to detect any adverse effects on their health consistent with the toxic effects of mercury. The mercury content of the women's hair (H-Hg) was used as the bio-indicator of mercury exposure. The women answered a 24-hour food recall questionnaire on the frequency of their fish consumption. They also underwent a clinical examination with their weight, stature, hemoglobinemia hemoglobin concentration in blood, and blood pressure being recorded. Significant relationships were found between fishing practices, the frequency of fish consumption and H-Hg levels with mercury contaminated women (H-Hg > 5 µg/g) being more likely to present neurological abnormalities (paresthesia, static and dynamic imbalance, poor motor coordination) than non-contaminated women.. No relationship was found between blood pressure and mercury levels. Women with higher H-Hg reported more infant deaths than did women with lower levels. A logistic regression analysis which included socio cultural traits, fish consumption habits and health characteristics was performed in order to determine the risks of contamination. Contaminated women were more likely to belong to those communities pursuing traditional fishing activities; moreover these women tended to be younger and frailer than other. They also exhibited mild neurological abnormalities and reported more infant deaths. These findings should stimulate local communities to take preventive actions directed towards the more "traditional" and vulnerable groups of population.

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“…Adequate intake of copper provides protection against lead, whereas higher intake of copper increases lead absorption [124][125][126][127] . The above studies clearly suggest that these micronutrients play a role in preventing toxic metal absorption and could also be co-administered during chelation therapy to maintain essential metal status during chelation treatment and could serve a dual purpose; i) to prevent possible essential metal deficiency syndrome and ii) to accelerate lead elimination due to their own antagonistic/biochemical/pharmacological effects 128,163) . A beneficial role of zinc supplementation during lead chelation therapy has been reported 15,129) .…”

Section: Coppermentioning

confidence: 99%

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Kalia¹,

Flora²

2005

Journal of Occupational Health

269

161

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Strategies for Safe and Effective Therapeutic Measures for Arsenic and LeadPoisoning: Kiran Kalia, et al. Department of Biosciences, Sardar Patel University, IndiaExposure to toxic metals remains a widespread occupational and environmental problem in world. There have been a number of reports in the recent past suggesting an incidence of childhood lead poisoning and chronic arsenic poisoning due to contaminated drinking water in many areas of West Bengal in India and Bangladesh has become a national calamity. Low level metal exposure in humans is caused by air, food and water intake. Lead and arsenic generally interferes with a number of body functions such as the central nervous system (CNS), the haematopoietic system, liver and kidneys. Over the past few decades there has been growing awareness and concern that the toxic biochemical and functional effects are occurring at a lower level of metal exposure than those that produce overt clinical and pathological signs and symptoms. Despite many years of research, we are still far from an effective treatment of chronic plumbism and arsenicosis. Medical treatment of acute and chronic lead and arsenic toxicity is furnished by chelating agents. Chelating agents are organic compounds capable of linking together metal ions to form complex ring-like structures called chelates. They have been used clinically as antidotes for acute and chronic poisoning. 2, 3-dimercaprol (BAL) has long been the mainstay of chelation therapy for lead or arsenic poisoning. Meso 2, 3, -dimercaptosuccinic acid (DMSA) has been tried successfully in animals as well as in a few cases of human lead and arsenic poisoning. DMSA could be a safe and effective method for treating lead or arsenic poisoning, but one of the major disadvantages of chelation with DMSA has been its Review inability to remove lead from the intracellular sites because of its lipophobic nature. Further, it does not provide protection in terms of clinical/ biochemical recovery. A new trend in chelation therapy is to use combined treatment. This includes the use of structurally different chelators or a combination of an adjuvant and a chelator to provide better clinical/ biochemical recovery in addition to lead mobilization. The present review article attempts to provide update information about the current strategies being adopted for a safe, effective and specific treatment for two major toxic metals or metalloid.

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Effects of Micronutrients on Metal Toxicity

Cited by 109 publications

References 71 publications

Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake

Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake

Fishing activity, health characteristics and mercury exposure of Amerindian women living alongside the Beni River (Amazonian Bolivia)

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

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