Effects of milk curd on saliva secretion in healthy volunteer compared to baseline, 2% pilocarpine and equivalent pH adjusted acetic acid solutions

Babaee, Neda; Gholizadehpasha, Atefeh; Zahedpasha, Samir; Moghadamnia, Yasaman; Zamaninejad, Shiva; Moghadamnia, Ali Akbar

doi:10.4103/0970-9290.90294

Cited by 7 publications

(3 citation statements)

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“…Pilocarpine is the first drug approved by the FDA (Federal Drug Administration) for treating deterioration of salivary glands 21,22,23 . However, it has many adverse effects such as sweating, rhinitis, nausea, increased urinary frequency, as well as increased gastrointestinal secretion of hydrochloric acid 24,25 , and it is contraindicated for many ailments 26,27 .…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

et al. 2014

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Introduction: The use of prolonged local drug delivery to the oral cavity offers multiple benefits, such as increasing the pharmacological action in the desirable local site and reducing the usual dose and the adverse effects. Pilocarpine is a cholinergic drug approved by the FDA for the treatment of glandular hypofunction; however, the extent of its adverse effects limits its use. Objective: The main aim of this study was to analyze the physical and chemical properties of films, including pH, thickness, solubility, consistency and the ability to release pilocarpine for a prolonged time. Additionally, the antimicrobial activity in two opportunistic pathogens in hyposialia (Streptococcus mutans and Candida albicans) was also assessed. Methodology: Chitosan and HPMC (Methocel K4M CR) films were prepared in 1% acetic acid and pilocarpine was added under magnetic stirring. PH, thickness and time of solubility in artificial saliva, as well as diffusion and drug release kinetics per cm 2 (OD=420nm) were assessed by spectrophotometry. The antimicrobial activity was tested by disk diffusion test against St. mutans ATCC 700610 and C. albicans ATCC 90029 at concentrations of hyposalivation (1.44x1.2x10 6 CFU and 10 3 CFU, respectively). Results: All the films, except for Hydroxypropyl methylcellulose / Pilocarpine formulation, were found to have optimal physical-chemical properties for handling, maintaining drug diffusion in 76% per cm 2 for four hours extended-release without showing antimicrobial activity at concentrations of hyposalivation. Conclusion: The films had optimum handling properties and a constant drug release; however, antimicrobial activity was not found.

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Section: Introductionmentioning

confidence: 99%

Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

et al. 2014

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“…Sialogogue drugs: Pilocarpine is a cholinergic agonist that stimulates muscarinic receptors of the salivary glands and increases salivary flow 85 . This drug, approved by the FDA, is used to treat the impairment of salivary glands 2 , however its use may have adverse effects such as sweating, rhinitis, nausea, increased urinary frequency, as well as increased gastrointestinal secretion of hydrochloric acid 86,87 .…”

Section: Rodríguez J Martínez G Rodríguez N Chapa M and Solís Jmentioning

confidence: 99%

Dental perspective on Sjögren’s syndrome: literature review

et al. 2015

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Abstract:The human body releases around 500-600mL of saliva daily, however when values of unstimulated whole saliva range from 0.1 to 0.2mL/ min, there is a condition called Hyposalivation or hyposialia. Hyposalia is characterized by a large number of systemic conditions, including Sjögren's syndrome, a chronic autoimmune disease that affects between 0.1 and 3% of the world population and is characterized by exocrinopathy of the salivary glands leading to glandular hypofunction and thus decreasing the normal salivary flow. Saliva is part of innate immunity, when there is a decrease in protein secretion, numerous oral manifestations occur such as dental caries, candidiasis, gingival disease, angular cheilitis, lymphomas of the salivary glands, dysphagia, erythematous and fissured tongue, among others. Currently there is no defined dental treatment, however there are alternative treatments by sialogogues and salivary substitutes, plus non-pharmacological therapies, which seek to maintain the ecology and oral conditions stable, in addition to preventive and restorative dental treatment for lesions already established as a consequence of the disease. The aim of this study is to conduct a literature review on the characteristics, classification, oral manifestations and dental management of Sjögren's syndrome.

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“…gingivitis and periodontitis) (64). Previous studies reported the potential effect of Aloe vera in quality of life and symptom improvement, and pain reduction in various types of dentistry problems including oral lichen planus (65), aphthous ulcer (66), and oral submucous fibrosis (67).…”

Section: Phytochemical Compositionmentioning

confidence: 99%

Aloe vera and health outcomes: an umbrella review of systematic reviews and meta-analyses

Sadoyu¹

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This umbrella review aims to summarize and assess the effects of Aloe vera on health outcomes. Methods: Only systematic reviews and meta-analyses of clinical trials that investigated the effects of Aloe vera on health outcomes were eligible. PubMed, Scopus, Embase, Cochrane database of systematic reviews, CINAHL, and AMED were searched from inception to October 2019. Two independent reviewers extracted data, assessed the methodological quality, and rated the credibility of evidence according to established criteria into convincing, highly suggestive, suggestive, weak, and not significant. Results: Ten articles reporting 71 unique outcomes of Aloe vera were included. Of these, 47 (67%) were nominally statistically significant based on the random-effects model (p ≤ 0.05). Only 3 outcomes were supported by highly suggestive evidence including the benefits of Aloe vera in the prevention of second-degree infusion phlebitis (RR: 0.18, 95% CI: 0.10-0.32) and chemotherapy-induced phlebitis based on the second-degree of severity and overall incidence (OR: 0.10, 95% CI: 0.07-0.14, and OR: 0.13, 95% CI: 0.08-0.20, respectively). Conclusions: The current evidence suggests the benefits of Aloe vera in the prevention of phlebitis induced by chemotherapy and intravenous infusion, particularly in the severe stage. Aloe vera also showed favorable effects in other indications, but the majority of the evidence had limitations including small sample size and poor methodological quality.

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Effects of milk curd on saliva secretion in healthy volunteer compared to baseline, 2% pilocarpine and equivalent pH adjusted acetic acid solutions

Abstract: Milk curd has a significant local impact, and the saliva increase depends on the dose. It seems that this effect is not only related to its acidic taste. As a result, factors other than pH are involved in the effect.

Cited by 7 publications

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Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

Physicochemical and antimicrobial evaluation of chitosan and hydroxypropyl methylcellulose films for prolonged release of pilocarpine

Dental perspective on Sjögren’s syndrome: literature review

Aloe vera and health outcomes: an umbrella review of systematic reviews and meta-analyses

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