Effects of Million Volt Irradiation on the Gastrointestinal Tract

Brick, Irving B.

doi:10.1001/archinte.1955.04430010040004

Cited by 49 publications

(7 citation statements)

References 3 publications

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“…Also, these complications are thought to be sometimes fatal (Brick 1955;Roswit et al 1972). In our present results, the incidence of the complications is very low, in spite of the irradiated dose of more than 5,000 grad.…”

Section: Therapy Of Gastric Carcinoma 451supporting

confidence: 48%

Combination therapy of gastric carcinoma with radiation and chemotherapy.

Asakawa¹,

Otawa²,

Yamada³

et al. 1982

Tohoku J. Exp. Med.

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The concurrent combination therapy of radiation and chemotherapy was performed in a total of 134 cases of stomach cancer. Radiation response of tumor was remarkable in 35 (37%) of 95 cases, irradiated more than 5,000 rad. Yearly survival rates in 81 cases, in which the scheduled curative treatment was completed, were 63% in one, 31% in two, 21% in three, 17% in four and 13% in five years. These rates were intimately correlated to tumor size and cancer type. However, this combination therapy accompanied some fatal complications in a few percent. From the results, it was concluded that this combination therapy should be valuable to prolong the life of patients with gastric cancer, and that the curable indications for this treatment should be T1-T3: MO cases with radio-responsive tumor.radiotherapy; chemotherapy; gastric carcinoma Gastric carcinoma is the most frequent one in Japan. In the treatment of gastric cancer the curable possibility is only expected by curative resection of the stomach. However, locally unresectable and medically inoperable cases are not rare, in spite of a remarkable progress of the diagnostic method for gastric carcinoma. For such cases in which gastrectomy is not indicated, chemotherapy is generally employed to prolong the life of a cancer patient, but its effect is greatly limited.On the other hand, the radiation therapy of gastric cancer has been thought to be inadequate, because of relative radioresistance of gastric carcinoma and of the limited radiotolerance of adjacent organs, such as the small intestine, large bowel and kidneys.Since 1967, we have been trying the concurrent combination therapy of gastric carcinoma with 6 MV x-ray and some anticancer drugs to potentiate the radiation effect on the malignant lesions within the irradiation field. In this therapy, it is expected that chemotherapy alone may be also effective on the subclinical invasions and/or apparent remote metastases in the outside of the irradiation field. In this study, radiation response of tumor, yearly survival rates and

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Section: Therapy Of Gastric Carcinoma 451supporting

confidence: 48%

Combination therapy of gastric carcinoma with radiation and chemotherapy.

Asakawa¹,

Otawa²,

Yamada³

et al. 1982

Tohoku J. Exp. Med.

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“…Early reports include the analysis of testicular cancer patients treated with para-aortic RT at Walter Reed Army Medical Center in the 1940s and 1950s (10). The volume of stomach in the field was not quantified.…”

Section: Late Radiation-induced Toxicity To the Stomachmentioning

confidence: 99%

Radiation Dose–Volume Effects in the Stomach and Small Bowel

Kavanagh

Pan

Dawson

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

475

334

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“…Early effects of therapeutic irradiation in the Walter Reed series were reported by Amory and Brick,l Friedman,Io~11 and Brick. 4 We have extended the follow-up for mortality to 17 years for all men studied by Dixon and Moore.8 With this data, we attempt to answer two questions: 1. Are the large differences in mortality among tumor groups, reported by Dixon and Moore, maintained in later years or do these early differences become less marked?…”

mentioning

confidence: 99%

Survival after surgery for germinal malignancies of the testis.I. Rates of survival in tumor groups

Nefzger

Mostofi

1972

Cancer

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We have extended the follow‐up for mortality to 17 years for 834 Army men treated surgically in the years 1940 to 1947 for germ cell tumors of the testis, the group first reported by Friedman and Moore and Dixon and Moore. Mortality was ascertained through the Veterans Administration by procedures known to be at least 98% complete. All other data used in this report were taken from punchcards prepared for the earlier work. Seventeen years after surgery, 53% of the 834 men were still alive, and 81% of 547 men who lived 2 years lived another 15 years. The prospect for survival to the 17th year after surgery for testis tumor never does quite achieve expectation as derived from the 1959–1961 life table for men. Men with embryonal carcinoma with or without seminoma, group II tumors as classified by Dixon and Moore, had the poorest survival at 2 years and also after 2 years, but survival after 2 years did not show the striking differences among tumor groups that were present in the first 2 years.

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Effects of Million Volt Irradiation on the Gastrointestinal Tract

Cited by 49 publications

References 3 publications

Combination therapy of gastric carcinoma with radiation and chemotherapy.

Combination therapy of gastric carcinoma with radiation and chemotherapy.

Radiation Dose–Volume Effects in the Stomach and Small Bowel

Survival after surgery for germinal malignancies of the testis.I. Rates of survival in tumor groups

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