Effects of Mining Activities on Gerbillus nanus in Saudi Arabia; A Biochemical and Histological Study

Almalki, Ahmed; Ajarem, Jamaan S.; Altoom, Naif; Al-Otaibi, Fahed S.; Maodaa, Saleh N.; Allam, Ahmed A.; Mahmoud, Ayman M.

doi:10.20944/preprints201908.0074.v1

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…The effectiveness of modified Biolasol ® in nephron protection was assessed based on the analysis of ALT and AST activities, total protein and urea concentrations as well as Na + and K + levels in the perfundates collected after starting and ending perfusion. A diagnostic tool was used to indirectly assess renal function [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Analysis of the results obtained confirms the effect of selenium on ischemia-reperfusion injury of isolated porcine kidneys.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

2020

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Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol® (modified Biolasol®), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se4+ ions at a dose of 1 µg/L into the Biolasol® preservation solution in the form of Na2SeO3 caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se4+ on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol® modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO32−) during ischemia/reperfusion.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

2020

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Heavy Metal Accumulation, Tissue Injury, Oxidative Stress, and Inflammation in Dromedary Camels Living near Petroleum Industry Sites in Saudi Arabia

Ajarem

Hegazy

Allam

et al. 2022

Animals

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The petroleum industry can impact the environment and human health. Heavy metals (HMs), including lead (Pb), cadmium (Cd), nickel (Ni), and vanadium (V), are toxic pollutants found in petroleum that can cause several severe diseases. This study investigated the impact of the oil industry on the Arabian camel (Camelus dromedarius) in the eastern region of Saudi Arabia, pointing to HMs accumulation, tissue injury, redox imbalance, inflammation, and apoptosis. Soil and camel samples (milk, blood, muscle, liver, and kidney) were collected from a site near an oil industry field and another two sites to analyze HMs. Pb, Cd, Ni, and V were increased in the soil and in the camel’s milk, blood, muscle, liver, and kidney at the polluted site. Serum aminotransferases, urea, and creatinine were elevated, and histopathological alterations were observed in the liver and kidney of camels at the oil industry site. Hepatic and renal lipid peroxidation, pro-inflammatory cytokines, Bax, and caspase-3 were increased, whereas cellular antioxidants and Bcl-2 declined in camels at the oil extraction site. In conclusion, the oil industry caused soil and tissue accumulation of HMs, liver and kidney injury, oxidative stress, and apoptosis in camels living close to the oil extraction site. These findings pinpoint the negative impact of the oil industry on the environment, animal, and human health.

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Use of Spilopelia senegalensis as a Biomonitor of Heavy Metal Contamination from Mining Activities in Riyadh (Saudi Arabia)

Almalki

Ajarem

Allam

et al. 2019

Animals

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Environmental pollution with heavy metals (HMs) is of serious ecological and public health concern worldwide. Mining is one of the main sources of HMs and can impact the environment, species diversity, and human health. This study assessed the value of Spilopelia senegalensis as a biomonitor of environmental contamination with metal(loid)s caused by mining activities. S. senegalensis was collected from a gold mining site and a reference site, and metal(loid)s and biochemical parameters were determined. Lead, cadmium, mercury, vanadium, arsenic, copper, zinc, and iron were significantly increased in the liver, kidney, and lung of S. senegalensis from the mining site. Serum transaminases, alkaline phosphatase, creatinine, and urea were significantly elevated in S. senegalensis from the mining site. Lipid peroxidation and nitric oxide were increased, whereas glutathione and antioxidant enzymes were diminished in the liver and kidney of S. senegalensis from the mining site. In addition, multiple histological alterations were observed in the liver, kidney, and lung of S. senegalensis. In conclusion, mining activities provoke the accumulation of metal(loid)s, oxidative stress, and tissue injury in S. senegalensis. Therefore, S. senegalensis is a valuable biomonitor of environmental pollution caused by mining activities and could be utilized in epidemiological avian studies of human health.

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Effects of Mining Activities on Gerbillus nanus in Saudi Arabia; A Biochemical and Histological Study

Cited by 3 publications

References 49 publications

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

Heavy Metal Accumulation, Tissue Injury, Oxidative Stress, and Inflammation in Dromedary Camels Living near Petroleum Industry Sites in Saudi Arabia

Use of Spilopelia senegalensis as a Biomonitor of Heavy Metal Contamination from Mining Activities in Riyadh (Saudi Arabia)

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