Effects of moderate doses of vitamin A as an adjunct to the treatment of pneumonia in underweight and normal-weight children: a randomized, double-blind, placebo-controlled trial

Abstract

Overall, we found no effect of a moderate dose of vitamin A supplementation on the duration of uncomplicated pneumonia in underweight or normal-weight children aged <5 y. However, a beneficial effect was seen in children with high basal serum retinol concentrations.

Epidemiology of community-acquired pneumonia in children of Latin America and the Caribbean: a systematic review and meta-analysis

“…This review found evidence in 25 published articles presenting data from Brazil, Argentina, Uruguay, Chile, Colombia, Venezuela, Mexico, and Ecuador. 11,24,28,31,32,36,44,47,49,50,[52][53][54][55]57,[62][63][64][65][69][70][71]73,76,78 These studies, conducted between 1986 and 2003, showed that 23-29.7% of CAP cases required hospitalization and that 3.2% required intensive care unit stays. 54 The median length of stay for patients admitted to general care was 11 days (range 5-13.5 days).…”

Vitamin a supplementation for prophylaxis or therapy in childhood pneumonia: A systematic review of randomized controlled trials

“…Seven of the nine therapy trials could be categorized as having low risk of bias (18)(19)(20)22,(24)(25); two trials (17,21) had missing components affecting the quality grading. A variety of outcomes were measured in these trials, from which some data could be extracted for meta-analysis.…”

Nutritional approach for increasing public health during pandemic of COVID-19: A comprehensive review of antiviral nutrients and nutraceuticals

“…VitA supplementation was studied as a potential intervention to accelerate recovery, minimize severity, and avoid recurrent episodes of acute infections of the lower respiratory tract. 121 , 122 However, it is not beneficial in those with lower respiratory infections, such as pneumonia 123 and supplementation may actually aggravate the condition. 120 , 124 , 125 As VitA can inhibit viral replication through the up-regulation of the innate immunity, 126 it seems that VitA might be promising in the prevention and treatment of lung infections stemmed from COVID-19.…”