Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice

Zhao, Xiaowen; Bian, Yanqing; Sun, Yichong; Li, Li; Wang, Lixuan; Zhao, Chao; Shen, Yinzhu; Song, Qingliang; Qu, Yine; Niu, Sijie; Wu, Wenshuang; Gao, Fang

doi:10.1016/j.exger.2013.05.063

Cited by 50 publications

(50 citation statements)

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“…Similarly, in a study on male SAMP8 mice -a senescence-accelerated strain-wherein the mice were maintained as sedentary or subjected to daily 15-min periods of swimming exercise, a significantly greater serum testosterone level was observed in the exercise group. 26 A similar trend is observed in humans, with physical activity being associated with higher testosterone levels, 27,28 whereas immobilization being associated with lower testosterone levels. 29,30 A previous study found no difference in total serum testosterone concentrations between sedentary and swimming rats.…”

Section: Discussionsupporting

confidence: 58%

Effects of swimming activity on the copulatory behavior of sexually active male rats

Allouh

2014

Int J Impot Res

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Physical activity has long been associated with better sexual function. This study investigated the effects of moderate swimming exercise on the copulatory behavior of sexually potent male rats. Two sets of sexually potent male rats -highly active and moderately active- were identified depending on baseline sexual activity. Each of the two sets of rats was further randomly divided into two groups (swimming and sedentary). There were 16 rats in each of the four study groups (highly active swimming, highly active sedentary, moderately active swimming and moderately active sedentary). The copulatory behavior parameters and serum testosterone levels were measured and compared between the rats of the swimming and sedentary groups following a month long training period in which rats were made to swim for 1 h every alternate day. Swimming significantly improved the sexual performance of highly active rats, as indicated by increased intromission frequency and intromission ratio, compared with the sedentary controls. Swimming improved both sexual desire and performance, as indicated by reduced mount latency and increased intromission ratio, respectively, in swimming moderately active rats compared with the sedentary moderately active controls. Therefore, swimming activity improves the copulatory behavior of both highly active and moderately active male rats.

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Section: Discussionsupporting

confidence: 58%

Effects of swimming activity on the copulatory behavior of sexually active male rats

Allouh

2014

Int J Impot Res

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“…P8 senescent mice exhibited signs of systemic inflammation affecting the liver, pancreas, cochlea, bones, testes and plasma levels of several cytokines and proinflammatory factors [29,31-37]. In addition to their peripheral inflamed phenotype, a proinflammatory brain environment may be involved in the neurodegenerative traits and/or cognitive deficiency in P8 mice [38].…”

Section: Resultsmentioning

confidence: 99%

Rcor2 underexpression in senescent mice: a target for inflammaging?

Álvarez-López

Molina-Martínez

Castro

et al. 2014

J Neuroinflammation

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BackgroundAging is characterized by a low-grade systemic inflammation that contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD). However, little knowledge is currently available on the molecular processes leading to chronic neuroinflammation. In this context, recent studies have described the role of chromatin regulators in inflammation and longevity including the REST corepressor (Rcor)-2 factor, which seems to be involved in an inflammatory suppressive program.MethodsTo assess the impact of Rcor2 in age-related inflammation, gene expression levels were quantified in different tissues and ages of the spontaneous senescence-accelerated P8 mouse (P8) using the SAMR1 mouse (R1) as a control. Specific siRNA transfection in P8 and R1 astrocyte cultures was used to determine Rcor2 involvement in the modulation of neuroinflammation. The effect of lipopolysaccharide (LPS) treatment on Rcor2 levels and neuroinflammation was analyzed both in vivo and in vitro.ResultsP8 mice presented a dramatic decrease in Rcor2 gene expression compared with R1 controls in splenocytes, an alteration also observed in the brain cortex, hippocampus and primary astrocytes of these mice. Rcor2 reduction in astrocytes was accompanied by an increased basal expression of the interleukin (Il)-6 gene. Strikingly, intraperitoneal LPS injection in R1 mice downregulated Rcor2 in the hippocampus, with a concomitant upregulation of tumor necrosis factor (Tnf-α), Il1-β and Il6 genes. A negative correlation between Rcor2 and Il6 gene expression was also verified in LPS-treated C6 glioma cells. Knock down of Rcor2 by siRNA transfection (siRcor2) in R1 astrocytes upregulated Il6 gene expression while siRcor2 further increased Il6 expression in P8 astrocytes. Moreover, LPS activation provoked a further downregulation of Rcor2 and an amplified induction of Il6 in siRcor2-tranfected astrocytes.ConclusionsData presented here show interplay between Rcor2 downregulation and increased inflammation and suggest that Rcor2 may be a key regulator of inflammaging.

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“…Exercise-induced elevations in mitochondrial biogenesis have been shown to decrease ROS production, suppress mitochondrial apoptotic susceptibility, and reduce myonuclear DNA fragmentation in numerous tissues of both young and old animals (Kwak et al 2006; Ljubicic et al 2009; Siu et al 2004; Siu et al 2005; Song et al 2006). However, only a few studies have investigated whether exercise causes beneficial adaptations in testicular tissue (Chigurupati et al 2008; Safdar et al 2011; Zhao et al 2013). For example, Safdar et al (2011) demonstrated that endurance exercise confers protection against progeroid aging by preventing decrements in mitochondrial biogenesis/function, suppressing apoptosis, and attenuating the loss in tissue mass in multiple tissues, including testicular tissue.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats

et al. 2014

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Mitochondrial dysfunction in various tissues has been associated with numerous diseases and conditions including aging. In testes, aging induces atrophy and a decline in male reproductive function but the involvement of mitochondria is not clear. The purpose of this study was to examine whether the mitochondrial profile differed with 1) aging, and 2) 10-weeks of treadmill exercise training, in the testes of young (6 month) and old (24 month) Fischer-344 (F344) animals. Old animals exhibited significant atrophy (30% decline; P<0.05) in testes compared to young animals. However, relative mitochondrial content (cytochrome c oxidase activity and cytochrome c levels) was not altered with age and this was consistent with the lack of change in the mitochondrial biogenesis regulator protein, PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and its downstream targets NRF-1 (nuclear respiratory factor-1) and Tfam (mitochondrial transcription factor A). No effect was observed in the pro- or anti-apoptotic proteins, Bax and Bcl-2, respectively, but age increased AIF (apoptosis inducing factor; P<0.05) levels. Endurance training induced beneficial mitochondrial adaptations that were more prominent in old animals including greater increases in relative mitochondrial content, biogenesis/remodeling (mitofusin 2; Mfn-2), and antioxidant capacity (MnSOD-mitochondrial superoxide dismutase; P<0.05). Importantly, these exercise-induced changes were associated with an attenuation of testes atrophy in older sedentary animals (P<0.05). Our results indicate that aging-induced atrophy in testes may not be associated with changes in relative mitochondrial content and key regulatory proteins and that exercise started in late-life elicits beneficial changes in mitochondria that may protect against age-induced testicular atrophy.

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Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice

Cited by 50 publications

References 72 publications

Effects of swimming activity on the copulatory behavior of sexually active male rats

Effects of swimming activity on the copulatory behavior of sexually active male rats

Rcor2 underexpression in senescent mice: a target for inflammaging?

Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats

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