Effects of modified Haizao Yuhu Decoction in experimental autoimmune thyroiditis rats

Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review

“…However the role of iodine may have been overestimated and other bioactive metabolites may have more significant contribution towards Sargassum's therapeutic claims. Recent research on modified decoction of ''Hai Zao Yu Hu Tang'' ( ) (Table 2) suggested that Sargassum may play a role as an immunomodulator (Song et al, 2011). The bioactive metabolites in Sargassum may inhibit thyroid growth induced by excessive iodine intake and improve immune function, which may be useful in treating Hashimoto's thyroiditis.…”

“…Besides iodine, bioactive phytochemicals in Sargassum may play a more important role in treating thyroid diseases. Resent research suggested Sargassum could reduce the levels of TPOAb and TgAb in rats (Song et al, 2011), which could be attributed to the immunomodulatory activity such as antiinflammatory and anti-allergic activities of Sargassum. The pathogenesis of autoimmune disorders of thyroid such as Hashimoto's thyroiditis and Graves' disease are still not clear.…”

Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU‐Induced Goiter Rats

“…According to traditional Chinese medicine (TCM) theory, goiter is mainly due to “Qi” stagnation and “phlegm” stasis [9]. Haizao Yuhu Decoction (HYD), which is described in a famous TCM monograph Waike Zhengzong (Summary of Surgical Medicine) in Ming Dynasty of China, has been used for approximately 500 years and famous for its efficacy in treating thyroid-related diseases especially goiter based on the clinical study [10].…”

Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism

“…biserrata Shan et Yuan (Duhuo) and Citrus reticulata Blanco (Chenpi and Qingpi). Modern research has shown that HYD exhibits significant protective effects by reversing serum T 3 , T 4 , TgAb and TPOAb levels, histopathological changes and TRAIL protein expression in the thyroid in rat models of experimental autoimmune thyroiditis (EAT) [ 8 ]. HYD with different compatibility can inhibit thyroid enlargement induced by propylthiouracil (PTU), to some extent, and the mechanism may be related to the activation of gene transcription of thyroid peroxidase (TPO) and thyroid globulin [ 9 ].…”