Effects of Molecular Weights of Sodium Hyaluronate on the Collagen Synthesis, Anti-inflammation and Transdermal Absorption

Abstract

Abstract:In this study, we examined the effects of various molecular weights (1, 10, 50, 100, 660, and 1500 kDa) of sodium hyaluronate (HA), which were prepared by enzyme hydrolysis, on the collagen synthesis, anti-inflammation and skin absorption. These HA did not significantly affect the viability of human dermal fibroblast Hs68 cells. Among them, 1500 kDa, 50 kDa HA most significantly increased collagen production by 59%, and 50% in the Hs 68 cells, respectively. Whereas 1500 and 660 kDa HA hardly pass through mouse transdermis membrane, lower molecular weights (1, 10, or 50 kDa) of HA showed time-dependent increase in skin permeation. HA of 50 kDa showed highest anti-inflammatory effects by reducing nitric oxide and tumor necrosis factor-α production in the RAW 264.7 cells, comparing to other HA (1, 10, and 100 kDa HA). Recently, there is no report about anti-wrinkle and anti-inflammatory effects and skin permeation of different molecular weights HA (1, 10 , 50, 100, 660 and 1500 kDa), which

Preparation and Functional Evaluation of Compound Bletilla striata Essence

“…Tremella fuciformis polysaccharides can increase water content in the skin epidermis, improve skin roughness and dispel facial freckles (Lourith et al, 2021). Sodium hyaluronate with high transdermal absorption ability is not irritative and makes skins feel flat and wet (Shin et al, 2016). Results show formulation of various extracts in rich polysaccharides at a certain ratio can well protect moisture and moisturize skin, regulate water-oil balance in skin and improve skin quality.…”