Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet

Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL/6J mice

“…Also, their circulating levels are linked to obesity, diabetes and insulin resistance which all are linked to reduced levels of adiponectin (Wang et al, 2011). The leptin levels reflect the amount of energy stored in adipose tissue which provide signals to the central nervous system of the body energy balance which helps to control the appetite, food intake, maintain stable body weight (Muoio and Lynis Dohm, 2002) and enhance insulin sensitivity (Shih et al, 2008). Reduction in the body weight results a rapid decrease in leptin levels (Geldszus et al, 1996).…”

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

“…Abundant biochemical data have shed light upon possible mechanisms of the anti-diabetic actions of M. charantia with the recurring theme being activation of the AMP-activated protein kinase system [94][95][96][97] . Other studies suggested a role of the a-and g-peroxisome proliferator-activated receptors (PPARa and PPARg) which are pivotal in lipid and glucose haemostasis and may mitigate insulin resistance [98,99] .…”

Anti-obesity effects of herbal extract YY312 in C57BL/6 mice fed a high-fat diet and 3T3-L1 cells

“…비만은 상기한 濕, 痰, 瘀 같은 병리적 산물이 기부나 복막, 장부 등에 유체되는 것이다. 따라서, 補氣, 健脾, 祛濕利水, 消導, 化痰 작용을 갖 는 한약을 치료제로 사용하였으며, 실제 항비만 효과가 있는 한약재로 人蔘 28) , 黃連 29) , 苦瓜 30) , 枸杞子 31) , 側柏葉 32) , 木香 33) , 小茴香 34) 등이 연구된 바가 있다. .…”