Effects of Monobenzyl ether of hydroquinone on 3T3 mouse fibroblast viability and ultrastructure

Erdoğan, Aslı; Mutlu, Hasan Serdar; Doğan, Sibel; Kotil, Tuğba

doi:10.1080/01913123.2021.1987605

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…During certain processes of PCD, electron microscopic examination revealed notable ultrastructural alterations. These included mitochondrial swelling and loss of cristae, which occurred alongside an increase in multivesicular bodies (MVBs) and autophagic vacuoles, or the presence of cell membrane blebs and a reduction in cell size [69]. In most cells, the primary fate of MVBs is fusion with lysosomes, which are acidic compartments containing lysosomal hydrolases responsible for degrading their contents.…”

Section: The Biogenesis and Isolation Of Evs In Pcdmentioning

confidence: 99%

Proteomic characterization of extracellular vesicles in programmed cell death

Xue,

Wong,

Zhao

et al. 2024

Proteomics

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Programmed cell death (PCD) is a fundamental biological process that plays a critical role in cell development, differentiation, and homeostasis. The secretion and uptake of extracellular vesicles (EVs) is one of the important regulatory mechanisms for PCD. EVs are natural membrane structures secreted by cells that contain a variety of proteins, lipids, nucleic acids, and other bioactive molecules. Due to their important roles in intercellular communication and disease progression, there is great interest in studying EVs and their cargo. Different protein components are sorted and packaged in EVs, allowing EVs to perform their functions. The study of EV proteomics helps us understand the role of PCD in the development of diseases. Meanwhile, proteomics is a powerful tool for studying the composition and function of EVs, which assists in the identification, quantification, and profiling of protein components of EVs, and provides insight into the molecular mechanisms involved in PCD and related diseases. In this review, we summarize the characteristics of EV proteomics in different types of PCD, compare different proteomic profiling strategies for EVs, and discuss the impact of EV proteomics on cell function and regulation during PCD, to understand its role in the pathogenesis of related diseases.

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Section: The Biogenesis and Isolation Of Evs In Pcdmentioning

confidence: 99%