Effects of Moringa oleifera Lam. aqueous leaf extracts on follicle stimulating hormone and serum cholesterol in Wistar rats

Nwamarah, Joy Ugo; Olawale, Otitoju; Otitoju, G.T.O.

doi:10.5897/ajb2014.13958

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…The secretion of both gonadotropins was markedly increased in group 5 rats, possibly due to the presence of the potent antioxidants: vanillin, tannins, phenolics and especially flavonoids and carotenoids found in M. oleifera leaves, which have the ability to alter androgen levels (Gopalakrishnan, 2016). The increased secretion of gonadotropins is consistent with previous reports of Nwamarah et al (2015) and Manhal et al (2017).…”

Section: Discussionsupporting

confidence: 89%

Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

2019

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Cadmium disrupts the blood-testes barrier, interferes with various antioxidant levels thus enhancing lipid peroxidation and ultimately leading to apoptosis and necrosis of testicular tissue. Moringa oleifera is a medicinal plant and a rich source of essential phytochemicals possessing antioxidant properties. The effect of aqueous leaf extract of M. oleifera on reproductive function following cadmium chloride induced oxidative stress in male Wistar rats was investigated. Forty adult male Wistar rats were assigned into five groups of eight rats each. Treatment was administered orally daily as follows: Group 1 (control): animal feed and tap water ad libitum; Group 2: 5 mg kg-1 cadmium chloride for 21 days; Group 3: 500 mg kg-1 of M. oleifera and 5 mg kg-1 of cadmium chloride for 21 days; Group 4: 5 mg kg-1 cadmium chloride for 21 days followed by 500 mg kg-1 M. oleifera for the next 35 days; Group 5: 5 mg kg-1 cadmium chloride for 21 days followed by 750 mg kg-1 M. oleifera for the next 35 days. At the end of treatment, blood was obtained by direct cardiac puncture for fertility hormone assay and testicular tissue specimens were harvested for semen analysis and determination of antioxidant levels. Results obtained indicated that rats treated with the various extracts had significantly increased superoxide dismutase, malondialdehyde and catalase levels, increased serum concentrations of testosterone, follicle stimulating hormone and luteinizing hormone and increased percentage of viable and normal spermatozoa compared to control and only cadmium chloride treated rats (p < 0.05). The results obtained suggest that treatments with M. oleifera extract could ameliorate possible cellular damage caused by administration of cadmium chloride.

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Section: Discussionsupporting

confidence: 89%

Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

2019

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“…The decrease in the laying percentage might be attributed to the negative effect of M. oleifera on the follicle stimulating hormone of laying hens (Ajuogu et al, 2019) which resulted to decreasing the laying potential. There was a reported decrease in FSH of female Wistar rats administered graded levels of M. oleifera leaf extract, where the control produced significantly higher amount of FSH compared to the experimental groups (Nwamarah et al, 2015). Ladokun et al (2015) also reported a significant decrease in the concentration of FSH in WAD bucks fed moringa leaves on the 4 th and 8 th weeks of the experiment.…”

Section: Resultsmentioning

confidence: 94%

Performance of Isa-Brown Layers and the Atomic Absorption Spectrophotometer of the Mineral Content of Eggs Produced by Moringa oleifera Leaf Powder Supplementation

Ugwuoke

Omeje

Okadi

et al. 2022

Braz. J. Poult. Sci.

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Moringa oleifera leaves richly contain numerous nutrients that can be used to induce performance in animals and when supplemented in layer feeds can improve the feed intake, body weight, egg qualities and mineral content of the eggs. The study was aimed to determine the performance of layers, egg quality and mineral profile of the eggs produced by inclusion of varying percentages of M. oleifera leaf powder in the feed of layers. Two hundred and forty Isa-brown layer birds were offered 0%, 2.5%, 5.0% and 7.5% M. oleifera leaf powder supplemented feeds respectively, using a completely randomized design. The mineral analysis was done following the procedure of the Association of Official Analytical Chemists using atomic absorption spectrophotometer. Data collected were analysed using analysis of variance at 0.05 level of significance. The results indicated that the body weight, feed intake, FCR, egg weight, egg length and shell thickness were significantly higher in layers fed M. oleifera leaf powder. However, the laying percentage was significantly higher in the control. The phosphorous, sodium, zinc, manganese, iron, copper, selenium and chromium contents of the eggs increased as the percentage of moringa inclusion increased. The eggs produced by layers fed with 5% M. oleifera leaf powder had significantly highest contents of magnesium, potassium and calcium, but decreased with further supplementation of moringa. The findings indicated that the supplementation of M. oleifera leaf powder at various levels improves the mineral contents of eggs but this is significantly achieved at a higher inclusion rate.

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“…Tamarind fruit contains tannin, saponin, sesquiterpenes, alkaloids, and phlobatannins (Silalahi, 2020). Moringa leaf extract (Jain et al, 2010;Nwamarah et al, 2015;Saleem and Naureen, 2021), kersen leaf (Alimar et al, 2022), bay leaf bark (Sutrisna et al, 2018), and okra fruit extract (Rahayuningsih et al, 2018) were also reported to decrease blood cholesterol of Wistar rats or exhibiting a hypolipidemic effect. Moringa leaf extract contains phenolics, flavonoids, and condensed tannins.…”

Section: Introductionmentioning

confidence: 99%

The Potency of Water Clover (<I>Marsilea crenata</I> C. Presl.) Leaves as Anticholesterolemic Functional Foods Through <I>In Silico</I> Study

Hardoko

Mutmainannah

2023

JIPK

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Highlight Research 1. There were 26 active compounds from water clover leaf extract that were identified using GC-MS 2. In silico approach was used to screen potential anticholesterolemic compounds from water clover leaf extract 3. Anticholesterolemic compounds from water clover leaf extract were interacted with HMG-CoA reductase receptors and compared to native ligand and medicine 4. There were 6 potential anticholesterolemic compounds identified from water clover leaf extract Abstract Water clover (Marsilea crenata C. Presl.) is a widely available plant in Indonesia and often utilized as a traditional food ingredient. This plant is also traditionally believed to contain compounds that can decrease blood cholesterol. This study aimed to determine the compounds in water clover which have the potential to decrease blood cholesterol through inhibition of the HMG-CoA enzyme using in silico approach. This research was done in several steps, i.e., extraction using ethyl acetate solvent, identification of chemical compounds using GC-MS, and screening of compounds with potential to be anticholesterolemic agent through in silico using PyRx 0.8 (AutoDockVina and Open Babel GUI version 2.4.1), Discovery Studio Visualizer 2021, and PyMOL™ 1.7.4.5 software. Results showed that ethyl acetate extract of water clover contained 26 compounds, 6 of which were potential to be anticholesterolemic agent, i.e., phytol, 1,2-benzenedicarboxylic acid, 2,4-di- tert-butylphenol, diethyl phthalate, 1,2,3,4-tetramethylbenzene, and dipentene. Binding affinity values of those six compounds were lower than the native ligand of the HMG-CoA reductase, although still higher compared to pravastatin. The binding affinity value of pravastatin was -7.13 kcal/mol and the binding affinity value of 3-methyl glutaric acid as a native ligand was -5.33 kcal/mol, meanwhile, the lowest binding affinity value of compounds in water clover was phytol (-6.37 kcal/mol) and the highest was dipentene (-5.40 kcal/mol). Through in silico study, there were six compounds from water clover leaf’s ethyl acetate extract that could inhibit the HMG-CoA reductase. Therefore, water clover leaf has the potential to become an anticholesterolemic functional food ingredient.

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Effects of Moringa oleifera Lam. aqueous leaf extracts on follicle stimulating hormone and serum cholesterol in Wistar rats

Cited by 9 publications

References 15 publications

Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

Performance of Isa-Brown Layers and the Atomic Absorption Spectrophotometer of the Mineral Content of Eggs Produced by Moringa oleifera Leaf Powder Supplementation

The Potency of Water Clover (<I>Marsilea crenata</I> C. Presl.) Leaves as Anticholesterolemic Functional Foods Through <I>In Silico</I> Study

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