Effects of Moringa oleifera Lam. Supplementation on Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes

Abstract

Different parts of the Moringa oleifera Lam. (MO) tree are consumed as food or food supplements for their nutritional and medicinal value; however, very few human studies have been published on the topic. The current work was aimed to provide ancillary analysis to the antidiabetic effects previously reported in a double-blind, randomized, placebo-controlled, parallel group intervention conducted in patients with prediabetes. Thus, the effect of MO leaves on blood and fecal inflammatory markers, serum lipid profile, plasma antioxidant capacity and blood pressure was studied in participants who consumed 6 × 400 mg capsule/day of MO dry leaf powder (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Differences between groups were assessed using each biomarker’s change score with, adjustment for fat status and the baseline value. In addition, a decision tree analysis was performed to find individual characteristics influencing the glycemic response to MO supplementation. No differences in the biomarker’s change scores were found between the groups; however, the decision tree analysis revealed that plasma TNF-α was a significant predictor of the subject’s HbA1c response (improvement YES/NO; 77% correct classification) in the MO group. In conclusion, TNF-α seems to be a key factor to identify potential respondents to MO leaf powder.

A Review on the Antidiabetic Properties of Moringa oleifera Extracts: Focusing on Oxidative Stress and Inflammation as Main Therapeutic Targets

“…While Gómez-Martínez and co-workers reported that giving subjects with prediabetes six daily capsules of Moringa oleifera leaf powder (2,400 mg/day) improved fasting blood glucose and glycated hemoglobin (HbA1c) when compared to the controls. Recently, Díaz-Prieto et al, demonstrated that consumption of 6 × 400 mg capsule/day of Moringa oleifera dry leaf powder for 12 weeks indicated that plasma tumor necrosis factor alpha (TNF-α) was a significant predictor of the subject’s glycated hemoglobin (HbA1c) response in subjects with prediabetes ( Díaz-Prieto et al, 2022 ). These results are consistent with some preclinical findings ( Jaja-Chimedza et al, 2018 ; Mohamed et al, 2019 ), indicating that Moringa oleifera leaf extracts might be useful complications identified during the early development of T2D.…”

Ultrasonic-Cellulase Synergistic Extraction of Crude Polysaccharides from Moringa oleifera Leaves and Alleviation of Insulin Resistance in HepG2 Cells

“…Not only does it have biological activities such as antioxidant and hypoglycaemic, but it has also shown outstanding results in alleviating the complications of diabetes. Pre-diabetic patients who consumed 6 × 400 mg of dried Moringa oleifera leaves powder capsules per day for 12 weeks showed a decrease in TNF-α in their bodies [ 22 ]. Methanolic extract from Moringa oleifera leaves promotes wound healing in diabetic rats [ 23 ].…”

Moringa oleiferaLam.: a comprehensive review on active components, health benefits and application

“…7 Terpenoids in M. oleifera. [83] Neoxanthin, [84] violaxanthin, [85] lutein, [86] zeaxanthin, [87] b-carotene, [88] tricyclohumuladiol, [89] 3bhydroxy-oleano-11,13(18)-diene-28-carboxylic acid, [90] oleanolic acid. addition, isothiocyanates, which are abundant in the seeds of M. oleifera, also exhibit these effects both in vitro and in vivo.…”