Effects of Morphologies of Thermosensitive Electrospun Nanofibers on Controllable Drug Release

Chen, Rong; Lin, Lulu; Wang, Hanyang; Zhai, Xinhui; Liang, Yong; Zhao, Benzheng; Yu, Zehao; Li, Kaiyue; Shen, Weiyang

doi:10.1089/ten.tea.2020.0258

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…The size and morphology of MOF particles have been controlled using different strategies, including change in solvent, modulator, temperature, reaction time, pH, metal to ligand ratio, microwave-assisted, and sonochemical synthetic techniques. Controlled modifications of the morphology and size of MOFs have been achieved through various methods in a wide range of applications including semiconductors, catalysts, gas storage, and separation. − The size and morphology of MOF particles influence physicochemical properties (material stability and adsorption and diffusion processes) and play a vital role in drug delivery by affecting the carrier biodistribution, drug release kinetics, cell internalization, and the clearance of the drug in complex biological media. − …”

Section: Resultsmentioning

confidence: 99%

Computational Study of Two Three-Dimensional Co(II)-Based Metal–Organic Frameworks as Quercetin Anticancer Drug Carriers

Parsaei

Akhbari

Tylianakis

et al. 2022

Crystal Growth & Design

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Two three-dimentional Co-based metal–organic frameworks with the formulae of [Co3(2-BrTPA)3].(DMF)4 (MUT-6) and [Co5(DBrTPA)4(DMF)6(HCOO)2] (MUT-7) [2-BrTPA = 2-bromoterephthalic acid, DBrTPA = 2,5-dibromoterephthalic acid] were synthesized through various synthetic techniques. The structures were fully characterized using a series of techniques, and the crystal structures were solved using single-crystal X-ray crystallography. Furthermore, the solvent stability test was conducted in various organic solvents. Using grand canonical Monte Carlo simulations, MUT-7 was proven to be a good candidate as a drug carrier for the quercetin anticancer drug because it shows remarkable uptake starting to adsorb at very low fugacity values and reaching a saturation loading as high as 200 mg/g.

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Section: Resultsmentioning

confidence: 99%

Computational Study of Two Three-Dimensional Co(II)-Based Metal–Organic Frameworks as Quercetin Anticancer Drug Carriers

Parsaei

Akhbari

Tylianakis

et al. 2022

Crystal Growth & Design

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“…In recent years, the development of neural tissue engineering has brought the hope of nerve regeneration. A scaffold made of electrospun nanofibers can play the function of the extracellular matrix, guide axonal repair after nerve injury, and deliver drug molecules and cytokines, which has broad application prospects in clinical preparations [ 111 , 112 ]. Polylactic acid-glycolic acid copolymer (PLGA) is a potential candidate due to its biodegradability and biocompatibility [ 113 ].…”

Section: Application Prospectmentioning

confidence: 99%

Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review

Yang

Zhao

et al. 2022

Molecules

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Vascular retinopathy is a pathological change in the retina caused by ocular or systemic vascular diseases that can lead to blurred vision and the risk of blindness. Lycium barbarum polysaccharides (LBPs) are extracted from the fruit of traditional Chinese medicine, L. barbarum. They have strong biological activities, including immune regulation, antioxidation, and neuroprotection, and have been shown to improve vision in numerous studies. At present, there is no systematic literature review of LBPs on vascular retinal prevention and treatment. We review the structural characterization and extraction methods of LBPs, focus on the mechanism and pharmacokinetics of LBPs in improving vascular retinopathy, and discuss the future clinical application and lack of work. LBPs are involved in the regulation of VEGF, Rho/ROCK, PI3K/Akt/mTOR, Nrf2/HO-1, AGEs/RAGE signaling pathways, which can alleviate the occurrence and development of vascular retinal diseases in an inflammatory response, oxidative stress, apoptosis, autophagy, and neuroprotection. LBPs are mainly absorbed by the small intestine and stomach and excreted through urine and feces. Their low bioavailability in vivo has led to the development of novel dosage forms, including multicompartment delivery systems and scaffolds. Data from the literature confirm the medicinal potential of LBPs as a new direction for the prevention and complementary treatment of vascular retinopathy.

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“…Controllable stimuli-responsive drug release is in close relationship with other parameters that guide drug release from nanofibers, and is a function of nanofiber morphology and physico-chemical properties of therapeutic agents [ 108 ]. Majority of thermosensitive polymers are often based on acrylamide derivatives which can be blended or combined with other polymers into a variety of morphologies.…”

Section: Delivery Of Therapeuticsmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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The fast advancement in nanotechnology has prompted the improvement of numerous methods for the creation of various nanoscale composites of which nanofibers have gotten extensive consideration. Nanofibers are polymeric/composite fibers which have a nanoscale diameter. They vary in porous structure and have an extensive area. Material choice is of crucial importance for the assembly of nanofibers and their function as efficient drug and biomedicine carriers. A broad scope of active pharmaceutical ingredients can be incorporated within the nanofibers or bound to their surface. The ability to deliver small molecular drugs such as antibiotics or anticancer medications, proteins, peptides, cells, DNA and RNAs has led to the biomedical application in disease therapy and tissue engineering. Although nanofibers have shown incredible potential for drug and biomedicine applications, there are still difficulties which should be resolved before they can be utilized in clinical practice. This review intends to give an outline of the recent advances in nanofibers, contemplating the preparation methods, the therapeutic loading and release and the various therapeutic applications.

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Effects of Morphologies of Thermosensitive Electrospun Nanofibers on Controllable Drug Release

Cited by 9 publications

References 44 publications

Computational Study of Two Three-Dimensional Co(II)-Based Metal–Organic Frameworks as Quercetin Anticancer Drug Carriers

Computational Study of Two Three-Dimensional Co(II)-Based Metal–Organic Frameworks as Quercetin Anticancer Drug Carriers

Effects of Lycium barbarum L. Polysaccharides on Vascular Retinopathy: An Insight Review

Nanofiber Carriers of Therapeutic Load: Current Trends

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