Nanoporous metal−organic frameworks (MOFs) have been gaining a reputation for their drug delivery applications. In the current work, MOF-801 was successfully prepared by a facile, cost-efficient, and environmentally friendly approach through the reaction of ZrCl 4 and fumaric acid as organic linkers to deliver 5-fluorouracil (5-FU). The prepared nanostructure was fully characterized by a series of analytical techniques including Fourier transform infrared spectroscopy, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive Xray spectroscopy, UV−vis spectroscopy, 1 H NMR spectroscopy, thermogravimetric analysis, high-performance liquid chromatography, and Brunauer−Emmett−Teller analysis. MOF-801 could be used for the delivery of the anticancer drug 5-FU due to its high surface area, suitable pore size, and biocompatible ingredients. Based on in vitro loading and release studies, a high 5-FU loading capacity and pH-dependent drug release behavior were observed. Moreover, the interactions between the structure of MOFs and 5-FU were investigated through Monte Carlo simulation calculations. An in vitro cytotoxicity test was done, and the results indicated that 5-FU@MOF-801 was more potent than 5-FU on SW480 cancerous cells, indicating the highlighted role of this drug delivery system. Finally, the kinetics of drug release was investigated.

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Herein, MOF-808 (MOF = metal−organic framework) based on zirconium tricarboxylate was synthesized to investigate the influence of decorating groups of folic acidconjugated chitosan (CS-FA) on drug-delivery efficiency. Quercetin (QU) was loaded on nondecorated MOF-808 and then decorated with a folic acid−chitosan conjugate. The properties and activities of modified MOF-808 were compared with unmodified MOF-808. QU@MOF-808@CS-FA exhibited favorable drugrelease properties, high drug-loading capacity, efficient targeting capability, and pH-dependent release behavior, highlighting the critical role of organic modification. A variety of characterization techniques were used to characterize MOF nanoparticles, including Fourier transform infrared, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, Brunauer−Emmett−Teller, ζ potential, and 1 H NMR. Additionally, Monte Carlo simulation calculations were carried out to examine the interactions between the structures of MOF-808 and QU. An in vitro cytotoxicity test was conducted, and the results identified that

Herein, UiO-66 and its two functional analogs (with −NO 2 and −NH 2 functional groups) were synthesized, and their potential ability as pH stimulus nanocarriers of quercetin (QU), an anticancer agent, was studied. UiO-66 is a low-toxicity, biocompatible metal−organic framework with a large surface area and good stability, which can be prepared through a facile and inexpensive method. Before and after drug loading, various analyses were conducted to characterize the synthesized nanocarriers. Moreover, Monte Carlo simulations were performed to investigate their structures and interactions with quercetin. The most promising drug loading potential and prolonged drug release (over 25 days) were observed in QU@UiO-66-NO 2 with 37% drug loading content, which was the best-tested sample that exhibited a higher release rate under acidic conditions (pH = 5) than that in normal cells (pH = 7.4). This behavior is known as pH-stimuluscontrolled ability. The cell treatment with free QU, UiO-66-R, and QU@UiO-66-R (R = −H, −NO 2 , and −NH 2 ) was performed, and an MTT assay was conducted on HEK-293 and MDA-MB-231 cells for the cytotoxicity study. Additionally, the kinetic modeling of drug release was investigated on the basis of the analysis of the drug release profiles.

A Zn(II)-based paddle wheel pillared-layered metal−organic framework, [Zn 2 (DBrTPA) 2 (DABCO)].(DMF) 2 (MUT-4), containing 1,4-diazabicyclo[2.2.2]octane (DABCO) and 2,5-dibromoterephthalic acid (DBrTPA) has been successfully synthesized with different synthetic methods, including solvothermal, sonochemical, and their mixing methods, some of which are energy-efficient, rapid, and room-temperature synthetic procedures. Structural characterization of MUT-4 with single-crystal Xray crystallography showed that it crystallizes in the tetragonal I4 1 / acd space group. MUT-4 has shown higher performance than known MOFs in the CO 2 adsorption such as UiO-66, UiO-66-