Synthesis and Application of MOF-808 Decorated with Folic Acid-Conjugated Chitosan as a Strong Nanocarrier for the Targeted Drug Delivery of Quercetin

Abstract

Herein, MOF-808 (MOF = metal−organic framework) based on zirconium tricarboxylate was synthesized to investigate the influence of decorating groups of folic acidconjugated chitosan (CS-FA) on drug-delivery efficiency. Quercetin (QU) was loaded on nondecorated MOF-808 and then decorated with a folic acid−chitosan conjugate. The properties and activities of modified MOF-808 were compared with unmodified MOF-808. QU@MOF-808@CS-FA exhibited favorable drugrelease properties, high drug-loading capacity, efficient targeting capability, and pH-dependent release behavior, highlighting the critical role of organic modification. A variety of characterization techniques were used to characterize MOF nanoparticles, including Fourier transform infrared, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, Brunauer−Emmett−Teller, ζ potential, and 1 H NMR. Additionally, Monte Carlo simulation calculations were carried out to examine the interactions between the structures of MOF-808 and QU. An in vitro cytotoxicity test was conducted, and the results identified that

Boosting Catalytic Performance of MOF-808(Zr) by Direct Generation of Rich Defective Zr Nodes via a Solvent-Free Approach

“…Then, hemiacetal (4) was formed after deprotonation. After that, hemiacetal (4) was protonated with a H + , and the protonated hemiacetal (5) was activated by the nucleophilic O atom in another alcohol. After the loss of water, (6) was formed, subsequent deprotonation led to the final product (7), and the H + eventually returned to MOF-808(Zr)-F. Therefore, the plentiful acid sites (terminal OH/OH 2 ) in MOF-808(Zr)-F play a crucial role in acetalization reaction.…”

“…Metal–organic frameworks (MOFs) emerge as a new class of porous crystal materials with excellent stability, large surface area, adjustable porosity, and accessible metal sites, becoming attractive candidates for catalyzing a broad range of heterogeneous catalytic reactions. − MOFs are conventionally well crystallized via hydro/solvothermal processing that limited their catalytic activities. − Defect engineering of MOFs offers a new opportunity to explore their potential peculiarity for targeted applications. − Two routes, de novo synthesis and post-synthetic treatment, are used to prepare defective MOFs as the literature reported; however, the modulator acid or harsh treatment condition is indispensable. − Until now, a highly efficient way to prepare defective MOFs is still lacking. , Therefore, the development of an environmental and efficient approach to prepare defective MOFs with abundant accessible active sites for boosting their redox/acid–base properties should be of great interest.…”

Introducing VO2+ Group in Phosphomolybdic Acid and Supporting on MOF-808 for Efficient Oxidative Desulfurization

“…The two main signals in 13 C NMR at 170 and 134 ppm are derived from carboxyl C in COO − and benzene C, respectively. 41 The broaden signal at 8.7 ppm in Figure 3d can be attributed to H atoms in the aromatic ring of BTC linkers. 42 After PMA/VO-PMA loading, the chemical environment for C and H atoms in the BTC linkers slightly changes.…”

Computational Simulation of CO2/CH4 Separation on a Three-Dimensional Cd-Based Metal–Organic Framework

“…Thus, the development of materials with optimal CO 2 binding energies and high selectivity is a complex issue with considerable practical implications. MOFs are porous inorganic materials that have received much attention recently owing to their outstanding characteristics, such as significant surface area and porosity, thermal/chemical stability, and tunability. − MOFs are considered promising materials for a variety of potential applications across various fields, including gas storage and separation, chemical sensing, biomedical applications, adsorption, and heterogeneous catalysis. − They are considered as one of the most promising physical adsorbent materials in the process of separating CO 2 /CH 4 . The engineering design of MOFs for gas separation applications is currently a rapidly growing area of research. − Numerous experimental and simulation-based studies have been documented involving the separation of CO 2 from CH 4 through the use of MOFs. − Considering the quadrupole moment and polarizability of CO 2 , current research efforts to enhance CO 2 uptake and selectivity primarily involves strategies aimed at improving the interaction between CO 2 and the frameworks.…”