Effects of moxibustion therapy on preventing and treating side effects from chemotherapy of malignant tumor patients

Fan, Yu; Zhao-min, Yang; Wu, Ming; Wu, Xuefei; Yan, Jili

doi:10.1007/s11726-011-0549-6

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…These results are consistent with a previous study which found that moxibustion could improve the total number of leukocytes in 23 patients with malignant tumors of the respiratory and digestive systems after chemotherapy. 13 In this study, we found that moxibustion could improve the antitumor effect of paclitaxel by reducing the total number of WBCs. The growth and metastasis of a tumor depend on the formation of neovascularization.…”

Section: Discussionmentioning

confidence: 71%

<p>Moxibustion Enhances Chemotherapy of Breast Cancer by Affecting Tumor Microenvironment</p>

Xue¹,

Fu²,

Zhu³

et al. 2020

CMAR

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Introduction: Chemotherapeutic drugs often cause obvious toxicity and side effects. Moxibustion can improve the immunity of cancer patients, enhance cellular immunity, and reduce the toxicity and adverse effects of radiotherapy and chemotherapy. In this study, the efficacy of moxibustion combined with paclitaxel on breast cancer was evaluated. Methods: A breast cancer mouse model was established. Hematoxylin and eosin staining was used to analyze tumor necrosis in mouse tumors. Immunohistochemistry, Western blot, and qPCR were used to detect the expression of CD34, hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor A(VEGFA), programmed death-1 (PD-1), and programmed death-1 ligand (PD-L1) in tumor tissues. Results: Moxibustion combined with paclitaxel significantly inhibited weight loss in breast cancer-burdened mice and increased the survival rate. Moxibustion combined with paclitaxel increased the number of white blood cells, thymus index, and spleen index, and enhanced immune function by upregulating interferon-gamma and interleukin-2 and downregulating interleukin-10 and transforming growth factor-β1. Notably, moxibustion combined with paclitaxel inhibited the angiogenesis of tumors through the downregulation of CD34, HIF-1α, and VEGFA, and overcame the immunosuppressive microenvironment by inhibiting the PD-1/PD-L1 signaling pathway. Conclusion: Moxibustion improves the body's immune function and enhances the efficacy of chemotherapy by overcoming the immunosuppressive microenvironment.

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Section: Discussionmentioning

confidence: 71%

<p>Moxibustion Enhances Chemotherapy of Breast Cancer by Affecting Tumor Microenvironment</p>

Xue¹,

Fu²,

Zhu³

et al. 2020

CMAR

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Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer

Zhang

Lin

Cheung

et al. 2018

Cochrane Database of Systematic Reviews

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Background Moxibustion, a common treatment in traditional Chinese medicine, involves burning herbal preparations containing Artemisia vulgaris on or above the skin at acupuncture points. Its intended effect is to enhance body function, and it could reduce the side effects of chemotherapy or radiotherapy and improve quality of life (QoL) in people with cancer. Objectives To assess the effects of moxibustion for alleviating side effects associated with chemotherapy, radiotherapy or both in people with cancer. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE via Ovid, Embase via Ovid and AMED (Allied and Complementary Medicine Database) from their inception to February 2018. We also searched databases in China including the Chinese BioMedical Literature Database (CBM), Chinese Medical Current Contents (CMCC), TCMonline, Chinese Dissertation Database (CDDB), China Medical Academic Conference (CMAC) and Index to Chinese Periodical Literature from inception to August 2017. Registries for clinical trials and other resources were also searched. Selection criteria We included randomised controlled trials (RCTs) comparing moxibustion treatment, including moxa cone and moxa stick, versus sham, no treatment or conventional treatment. Data collection and analysis Two review authors (HWZ and FC) independently extracted data on study design, participants, treatment and control intervention, and outcome measures, and they also assessed risk of bias in the included studies. We performed meta-analyses, expressing dichotomous outcomes as risk ratios (RR) and continuous outcomes as mean differences (MD), with 95% confidence intervals (CI).

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Effect of moxibustion on quality of life after chemotherapy in patients with the malignant tumor

Tang

Zou

et al. 2021

Medicine

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Background: The quality of life of patients with malignant tumor can be affected by the severity and treatment of the disease. After chemotherapy, the main symptoms are gastrointestinal reactions, including nausea, vomiting, loss of appetite, and so on, and hematologic response including leukopenia, anemia, and bleeding in severe cases. Currently, moxibustion is conducted to improve the living life of patients after chemotherapy. This article will make a comprehensive and objective discussion in terms of the effect of moxibustion on quality of life after chemotherapy in patients with malignant tumors. Methods: After searching the Chinese database (CNKI, VIP, Wanfang Database, and Chinese Biomedical Database) and English database (PubMed, Embase, the Cochrane Library Web of Science), Meta-analysis was performed according to the randomized controlled trial of moxibustion after chemotherapy in patients with malignant tumors. The retrieval time was limited from the time of building the repository to October 2020. Two researchers independently conducted data extraction and quality evaluation of literature on the included studies, and RevMan5.3 was used for Meta-analysis on the included literature. Results: After analyzing the included literature, this study suggested that by combining chemotherapy with moxibustion, the adverse reactions such as nausea, vomiting, appetite, and insomnia can be relieved. Meanwhile, the psychological burden of patients can be alleviated to a certain extent. Therefore, moxibustion can improve the overall health level and quality of life of patients with malignant tumors. Conclusion: This study will provide evidence-based medical evidence that moxibustion can improve the quality of life after chemotherapy and reduce chemotherapy's adverse reactions in patients with malignant tumors. Ethics and dissemination: Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval was not required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/Q5NYM.

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Effects of moxibustion therapy on preventing and treating side effects from chemotherapy of malignant tumor patients

Cited by 3 publications

References 2 publications

<p>Moxibustion Enhances Chemotherapy of Breast Cancer by Affecting Tumor Microenvironment</p>

<p>Moxibustion Enhances Chemotherapy of Breast Cancer by Affecting Tumor Microenvironment</p>

Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer

Effect of moxibustion on quality of life after chemotherapy in patients with the malignant tumor

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