Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio)

Wang, Ju; Jia, Bo; Li, Yanhong; Ren, Bo; Liang, Hanlin; Yan, Dongyan; Xie, Hua; Zhang, Xiaodong; Liang, Hongwu

doi:10.1016/j.jhazmat.2020.122724

Cited by 23 publications

(5 citation statements)

References 66 publications

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“…However, it was reported that (−)‐ R‐ indoxacarb was 1.3 times more toxic to zebrafish embryos at 96 h postfertilization than was (+)‐ S‐ indoxacarb (Fan et al 2017). It was found that (−)‐ R‐ indoxacarb was more toxic to male zebrafish liver and female zebrafish brain than (+)‐ S‐ indoxacarb (Wang et al 2020). So, the high enrichment and high toxicity of (−)‐ R ‐indoxacarb may cause unnecessary tissue residue burden on aquatic organisms.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 30% of currently registered pesticide active ingredients contain one or more chiral centers (Sekhon 2009). In China, approximately 40% of currently applied pesticides are chiral, and this proportion is increasing with the introduction of new compounds (Ye et al 2010(Ye et al , 2015Zhang et al 2011;Wang et al 2020). The enantioselectivity of chiral pesticides has also attracted broad attention (Xu et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Liang

Qiu

2021

Enviro Toxic and Chemistry

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Indoxacarb is a typical chiral insecticide widely used in agricultural pest control. In the present study, zebrafish was used as a model animal to explore the enantioselective bioaccumulation behavior of indoxacarb to nontarget species in aquatic environments. Zebrafish were exposed to 0.025 and 0.1 mg/L rac-indoxacarb solution for 12 d under the semistatic method, and the bioconcentration factor (BCF) and enantiomeric fraction of zebrafish were investigated. The results showed that the (−)-R-indoxacarb preferentially accumulated in zebrafish. The BCF values at 0.025 mg/L exposure levels were 1079.8 and 83.4 L/kg for (−)-R-indoxacarb and (+)-S-indoxacarb after 12 d, respectively. The BCF values at 0.1 mg/L exposure levels were 1752.1 and 137.0 L/kg for (−)-R-indoxacarb and (+)-S-indoxacarb after 10 d, respectively. The half-life values of (−)-Rindoxacarb and (+)-S-indoxacarb were 3.47 and 2.05 d for 0.025 mg/L concentration exposure and 4.95 and 2.66 d for 0.1 mg/L concentration exposure, respectively. The enantiomeric fraction values were in the range of 0.48 to 0.55 and 0.89 to 1.00 for water and zebrafish samples, respectively. Studies on the enantioselective bioaccumulation behavior of indoxacarb will provide data for assessing the environmental fate and potential toxic effects of indoxacarb on aquatic organisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Liang

Qiu

2021

Enviro Toxic and Chemistry

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“…A majority of chiral pesticides have been produced, used, and evaluated as racemate; whereas, the enantiomers of pesticides may differ in toxicity, activity, metabolism, degradation behavior, and biotransformation [5,6]. One stereoisomer may be effective in fighting against a given target, while the other stereoisomer may be inactive, with different activities, or even cause adverse effects on non-target species including human beings [3,[7][8][9]. For instance, (-)-R-tebuconazole has higher fungicidal activity than (+)-S-tebuconazole [6], however, (-)-R-tebuconazole is highly toxic to aquatic non-target organisms (Scenedesmus obliquus, Daphnia magna, and Danio rerio) [10].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of penthiopyrad enantiomers and its metabolite in vegetables, fruits, and cereals using ultra‐high performance liquid chromatography–tandem mass spectrometry

Zhao

Liu

Liang

et al. 2021

J of Separation Science

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Penthiopyrad is a novel succinate dehydrogenase inhibitor that has one chiral center and exists a metabolite, 1-methyl-3-trifluoromethyl-1H-pyrazole-4carboxamide in its residue definition. An efficient analytical method for the simultaneous determination of penthiopyrad enantiomers and its metabolite in eight matrices were developed using modified quick, easy, cheap, effective, rugged, safe method, coupled with chiral stationary phase and ultra-high performance liquid chromatography-tandem mass spectrometry. The absolute configuration of penthiopyrad enantiomers was confirmed by polarimetry and electronic circular dichroism. Eight polysaccharide-based chiral stationary phases were evaluated in terms of the enantioseparation of penthiopyrad and separation-related factors (the mobile phase, flow rate and the column temperature) were optimized. To obtain an optimal purification, different sorbent combinations were assessed. The linearities of this method were acceptable in the range of 0.005 to 1 mg/L with R 2 > 0.998, while the limits of detection and quantification were 0.0015 mg/kg and 0.01 mg/kg for two enantiomers and its metabolite. The average recoveries of R-(-)-penthiopyrad, S-(+)-penthiopyrad and the metabolite ranged from 75.4 to 109.1, 69.5 to 112.8, and 70.0 to 108.5%, respectively. The intra-day and inter-day relative standard deviations were less than 18.8%. The analytical method was accurate and convenient, which can support their further research on stereoselective degradation, residual monitoring and risk assessment.

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“…The existence of three CNTs categories has been reported, related to their diameter, consisting of low crystallinity and low specific surface area CNTs (large-diameter multi-walled CNTs (MWCNTs)), low crystallinity and higher specific surface area CNTs (large-diameter single-walled and double-walled CNTs (SWCNTs and DWCNTs)), and high crystallinity and moderate specific surface area CNTs (small-diameter SWCNTs) [ 8 ]. MWCNTs offer high tensile strength, elasticity, electrical conductivity, and thermal conductivity, as well as a higher suitability for modification or functionalization compared to other compounds [ 9 ], and are the most extensively produced CNT [ 10 ]. Despite being reported for the first time 50 years ago [ 11 ], novel application fields for this particular type of CNT still keep appearing [ 12 ], which also increase the potential appearance of new exposure scenarios [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…MWCNTs offer high tensile strength, elasticity, electrical conductivity, and thermal conductivity, as well as a higher suitability for modification or functionalization compared to other compounds [ 9 ], and are the most extensively produced CNT [ 10 ]. Despite being reported for the first time 50 years ago [ 11 ], novel application fields for this particular type of CNT still keep appearing [ 12 ], which also increase the potential appearance of new exposure scenarios [ 10 ]. In most cases, carbon nanotube risk assessment studies have been focused on mammalian cell lines and laboratory animals, where mechanisms associated with their potential toxicity have been determined [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Low Toxicological Impact of Commercial Pristine Multi-Walled Carbon Nanotubes on the Yeast Saccharomyces cerevisiae

et al. 2021

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Carbon nanotubes (CNTs) have attracted the attention of academy and industry due to their potential applications, being currently produced and commercialized at a mass scale, but their possible impact on different biological systems remains unclear. In the present work, an assessment to understand the toxicity of commercial pristine multi-walled carbon nanotubes (MWCNTs) on the unicellular fungal model Saccharomyces cerevisiae is presented. Firstly, the nanomaterial was physico-chemically characterized, to obtain insights concerning its morphological features and elemental composition. Afterwards, a toxicology assessment was carried out, where it could be observed that cell proliferation was negatively affected only in the presence of 800 mg L−1 for 24 h, while oxidative stress was induced at a lower concentration (160 mg L−1) after a short exposure period (2 h). Finally, to identify possible toxicity pathways induced by the selected MWCNTs, the transcriptome of S. cerevisiae exposed to 160 and 800 mg L−1, for two hours, was studied. In contrast to a previous study, reporting massive transcriptional changes when yeast cells were exposed to graphene nanoplatelets in the same exposure conditions, only a small number of genes (130) showed significant transcriptional changes in the presence of MWCNTs, in the higher concentration tested (800 mg L−1), and most of them were found to be downregulated, indicating a limited biological response of the yeast cells exposed to the selected pristine commercial CNTs.

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Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio)

Cited by 23 publications

References 66 publications

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio)

Simultaneous determination of penthiopyrad enantiomers and its metabolite in vegetables, fruits, and cereals using ultra‐high performance liquid chromatography–tandem mass spectrometry

Low Toxicological Impact of Commercial Pristine Multi-Walled Carbon Nanotubes on the Yeast Saccharomyces cerevisiae

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