Effects of Muscone on Random Skin Flap Survival in Rats

Kailiang, Zhou; Zhang, Yihui; Lin, Dingsheng; Xianyao, Tao

doi:10.1055/s-0035-1565264

Cited by 31 publications

(17 citation statements)

References 21 publications

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“…[17][18][19] Our previous study also showed that Traditional Chinese Medicines, such as Muscone, have positive effects to promote the survival of random skin flap as well as enhance the expression of VEGF. 20 In this study, the expression of VEGF in salidroside-treated flaps was markedly higher, compared with the control group, both in terms of immunohistochemical staining and Western blot. Furthermore, the MVD in area II of the flap, and the number of vessels revealed by flap angiogram, was significantly larger in the salidroside group.…”

Section: Discussionmentioning

confidence: 49%

Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing Angiogenesis and Inhibiting Apoptosis

Chen

Zhou

Weng

et al. 2016

J reconstr Microsurg

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Flap necrosis is frequently observed in flap transfer operations. Salidroside has been reported to reduce cell apoptosis by alleviating inflammation and oxidative stress. We investigated the effects of salidroside on the survival of random skin flaps. The McFarlane flap model was established in 80 rats that were divided into two groups and administered salidroside or saline solution intraperitoneally over 7 days. The area of necrosis and the extent of tissue edema were measured. Angiogenesis was assessed via lead oxide-gelatin angiography, immunohistochemistry for CD34, and VEGF expression. Cell apoptosis was evaluated by expression of cleaved caspase 3, caspase 3, Bax, and Bcl-2. The inflammatory response was evaluated using an ELISA kit for TNF-α and IL-6 in serum. Oxidative stress was assessed by measuring the activity of superoxide dismutase (SOD) and the level of malondialdehyde (MDA). Compared with controls, salidroside-treated flaps featured a greater area of surviving tissue and less edema. It also promoted the expression of VEGF and increased skin flap angiogenesis. Cell apoptosis, inflammation reaction, and oxidative stress were significantly attenuated in the salidroside group. Salidroside has a positive effect on improving random skin flap survival.

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Section: Discussionmentioning

confidence: 49%

Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing Angiogenesis and Inhibiting Apoptosis

Chen

Zhou

Weng

et al. 2016

J reconstr Microsurg

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“…Random-pattern skin flaps are commonly used in plastic surgery to cover skin defects, which are caused by trauma, oncologic resection, or congenital conditions ( Tanaka et al, 2003 ; Harder et al, 2008 ; Wang et al, 2014 ; Kanayama et al, 2017 ). However, necrosis of partial flaps, one of the most frequent post-operative complications, limits their clinical application, as it restricts the length-to-width ratio of flaps to 1.5 or 2:1 ( Kailiang et al, 2016 ). The viability of random flaps depends on an adequate blood supply; thus, tissue necrosis in distal random flaps is typically due to a lack of angiogenesis ( Stell, 1976 ).…”

Section: Introductionmentioning

confidence: 99%

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Lin

et al. 2018

Front. Pharmacol.

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Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. Sal B improved the survival area, reduced tissue edema, and increased the number of microvessels in skin flaps after 7 days, whereas an autophagy inhibitor (3-methyladenine) reversed the Sal B-induced increase in flap viability. In addition, Sal B stimulated angiogenesis, inhibited apoptosis, reduced oxidative stress, and upregulated autophagy in areas of ischemia. Moreover, the effects of Sal B on angiogenesis, apoptosis, and oxidative stress were reversed by autophagy inhibition. Overall, our findings suggest that Sal B has pro-angiogenesis, anti-apoptosis, and anti-oxidative stress effects by stimulating autophagy, which enhances the survival of random-pattern skin flaps.

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“…Adequate blood perfusion is essential to improve the survival of random skin flaps. 18,19 In addition, ischemia-reperfusion injury is considered the major cause of skin flap necrosis, which is associated with a series of pathological processes, including ischemia, free radical damage, leukocyte adhesion, and Ca 2þ overload; a large number of inflammatory mediators are produced in response to tissue and blood vessel damage. 20 In our study, bezafibrate improved flap survival; on postoperative day 7, the areas of surviving tissue in the bezafibrate group were significantly larger than those in the control group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bezafibrate on the Survival of Random Skin Flaps in Rats

Lin

et al. 2016

J reconstr Microsurg

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Background Bezafibrate is widely used in clinics for its comparable angiogenic effect. Our research is to investigate the effect of bezafibrate on random skin flap survival. Materials and Methods The "McFarlane flap" rat models were established in 30 male Sprague-Dawley rats which were divided into two groups. The treatment group was given bezafibrate (400 mg/kg/day; gavage administration), and the control group received the vehicle. The flap surviving area was measured after 7 days, and the tissue samples were taken for histological analysis and edema measurement. Vascular endothelial growth factor (VEGF) was determined using immunohistochemical methods. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were examined with kits. Results Seven days after the operation, the surviving area in the treatment group was larger than in the control group (p < 0.01). The expression of VEGF was increased in the treatment group compared with that in the control group. And the activity of SOD was lower in the treatment group compared with those in the control group (p < 0.01). However, tissue edema, inflammatory cell infiltration, and MDA level were markedly lower in the treatment group than those in the control group (p < 0.01). Conclusion Bezafibrate improves the survival of random skin flaps effectively.

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Effects of Muscone on Random Skin Flap Survival in Rats

Abstract: Muscone have a positive effect to promote the survival of random skin flap.

Cited by 31 publications

References 21 publications

Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing Angiogenesis and Inhibiting Apoptosis

Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing Angiogenesis and Inhibiting Apoptosis

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Effects of Bezafibrate on the Survival of Random Skin Flaps in Rats

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