Effects of mycotoxins on human immune functions in vitro

Berek, Livia; Petri, I; Mesterházy, Ákos; Téren, Joseph; Molnár, Joséph

doi:10.1016/s0887-2333(00)00055-2

Cited by 169 publications

(88 citation statements)

References 8 publications

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“…Supporting our data presented here in, Jaradat et al [28] demonstrated that an toxin acute exposure of animals or human to T-2 toxin resulted in severe damage to actively dividing cells in tissues such as bone marrow, lymph nodes, spleen, thymus and intestinal mucosa. This is also in agreement to other studies that reported the exposure to T-2 toxin either enhanced or suppressed B and T lymphocyte mitogen proliferation in a dose dependent manner [29,30] . Therefore, it is not surprising if T-2 toxin, depending on dose, time of administration and cell origin can induce different effects on immune cell function [31][32][33][34] .…”

Section: Results and Discusstionsupporting

confidence: 93%

T-2 Toxin Regulated Ganoderma lucidum Induced Cytokine Release

Ahmadi¹,

Riazipour²

2008

American J. of Immunology

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Abstract:The water-soluble extract of Ganoderma lucidum (Reishi) has been used as immunomodulator to stimulate spleen cells proliferation and cytokine expression. It has also been shown that at some level of exposure, T-2 toxin typically act as immunosuppressive agent and can increase disease susceptibility. The aim of this study was to investigate the effect of T-2 toxin on cytokine production by Ganoderma lucidum (G. lucidum) treated-cells. Mice peritoneal macrophages and lymphoid T cells were prepared by usual manner and plated out at 1×10 6 or 1×10 4 cell/well respectively in RPMI 1640 supplemented with 10% FCS, 50 µg streptomycin and 50U penicillin. Cells were incubated with different concentrations of G. lucidum in the presence or absence of 1 ng mLT-2 toxin at 37°C and 5% CO 2 for 48 h. Cell free medium was removed and used for cytokine assay by ELISA method. The results showed that T-2 toxin in the absence of G.lucidum enhanced IL-2, IFN-γ release compared with control group, but it reduced the production of other cytokines. G. lucidum enhanced the production of IL-1β, TNF-α, IL-12, IL-2 and IFN-γ compared with control group, but reduced IL-4 and IL-10 release. T-2 toxin, up regulated the enhancement effect of G. lucidum on IFN-γ, IL-2 and TNF-α, but it down regulated its effect on the production of other cytokines. In conclution our results indicate that T-2 toxin at 1 ng mL −1 may augment the immunomodulating effects of G. lucidum on cytokine release.

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Section: Results and Discusstionsupporting

confidence: 93%

T-2 Toxin Regulated Ganoderma lucidum Induced Cytokine Release

Ahmadi¹,

Riazipour²

2008

American J. of Immunology

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“…Luongo et al (2008) demonstrated that ZEN delivers immunotoxic effects, but its role in inflammations has not been fully explained because ZEN can both suppress and induce the production of proinflammatory cytokines (Ben Salah-Abbes et al 2008, Marin et al 2010, 2011. ZEN also induces changes in immune parameters in humans (Berek et al 2001) and mice (Abbès et al 2013). In an in vitro experiment, ZEN inhibited the proliferation of mitogen-stimulated lymphocytes and stimulated the production of IL-2 and IL-5 (Murata et al 2003).…”

Section: Introductionmentioning

confidence: 99%

The effect of in vivo exposure to zearalenone on cytokine secretion by Th1 and Th2 lymphocytes in porcine Peyer’s patches after in vitro stimulation with LPS

Obremski¹

2014

Polish Journal of Veterinary Sciences

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Most research studies investigating the estrogenic effects of zearalenone (ZEN) focus on the mycotoxin's effect on the reproductive system. Since estrogen receptors are present on various types of immunocompetent cells, ZEN can also modify diverse immune functions. This study analyzed immunocompetent cells isolated from Peyer's patches in the ileum of pigs administered ZEN in the estimated daily dose of 8 μg kg -1 BW (equivalent of 100 μg kg -1 feed per day -1 ). The objective of the study was to determine whether long-term exposure to low ZEN doses below the NOEL threshold leads to changes in the percentages of lymphocyte subpopulations and cytokine secretion by Th1

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“…Several studies have suggested the potential of aflatoxin to play suppressive roles on the immune function, increasing susceptibility to infectious diseases or reactivating chronic infections, and decreasing vaccine and drug efficacy (Berek et al 2001;Turner et al 2003;Jiang et al 2005Jiang et al , 2008Oswald et al 2005). Specifically, recent studies conducted in Ghana and…”

Section: Nutrition and Health Implicationsmentioning

confidence: 99%

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

Ayalew¹,

Hoffmann²,

Lindahl³

et al. 2016

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Focusing the 2015 Annual Trends and Outlook Report (ATOR) on nutrition will contribute to a broader understanding of the critical role of nutrition in achieving international, continental, and national economic growth targets through agriculture, food security, and nutrition. This report presents information and analysis in support of evidence-based policy making that should inform the second generation of CAADP national investment plans now being developed. This is an important moment for shaping the region’s future and ensuring that the much-needed agriculture-led growth and development agenda can simultaneously deliver on improving nutrition, saving lives, improving productivity and health, and curbing nutrition-related diseases and the associated public health expenditures. These investment plans should address not only the usual elements of undernutrition but also widespread micronutrient deficiencies (termed “hidden hunger”) and the growing problem of overweight and obesity that is associated with economic growth.1 introduction 2 The African union policy environment toward enabling action for nutrition in Africa 3 Africa’s progress toward meeting current nutrition targets 4 Economic development and nutrition transition in Ghana: taking stock of food consumption patterns and trends 5 Making African agriculture and food systems work for nutrition: what has been done, and what needs to be done? 6 Lessons learned from the evaluation of Helen Keller International’s enhanced homestead food production program 7 The role of biofortification as part of more diverse diets in Africa: progress, challenges, and opportunities 8 The role of mycotoxin contamination in nutrition: the aflatoxin story 9 The challenges, opportunities, and lessons learned in evidence-informed decision making in Africa 10 Evaluating nutrition-sensitive programs: challenges, methods, and opportunities 11 Supporting multisectoral action: capacity and nutrition leadership challenges facing Africa 12 Tracking key CAADP indicators and implementation processes 13 Summary and policy recommendations: toward a nutrition revolution for AfricaReportPRIFPRI1; ReSAKSS; HarvestPlus; B Promoting healthy food systemsDSGD; WCAO; ESAO; HarvestPlus; PHND; A4NH; MTIDCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

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Effects of mycotoxins on human immune functions in vitro

Cited by 169 publications

References 8 publications

T-2 Toxin Regulated Ganoderma lucidum Induced Cytokine Release

T-2 Toxin Regulated Ganoderma lucidum Induced Cytokine Release

The effect of in vivo exposure to zearalenone on cytokine secretion by Th1 and Th2 lymphocytes in porcine Peyer’s patches after in vitro stimulation with LPS

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

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