Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury

Tissue damage in rat ovaries subjected to torsion and detorsion: effects of l-carnitine and N-acetyl cysteine

“…L-Carnitine has been shown to be valuable also in the recovery of gastric mucosa, liver, neuron and kidney tissues, which were subjected to ischemia and reperfusion in different studies [11][12][13][14]. NAC has also been studied on ischemia-reperfusion injuries of tissues like testis, myocard, and kidney and was shown to be effective in the treatment of those injuries [15][16][17][18][19]. Although tissue damage diminishes by long period of reperfusion, our results show that, treatment with both Lcarnitine and NAC accelerates tissue recovery.…”

“…Later, as a precursor of glutathione and as a well-known thiol containing antioxidant, NAC was discovered as a scavenger of FORs [17,18]. NAC easily penetrates cell membranes and unlike cysteine, the rate-limiting amino acid in glutathione synthesis, has a very low toxicity [16].…”

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

“…Many scientists report renal I/R injury as the main reason for acute renal failure (ARF). [1][2][3] In spite of several mechanisms that had been proposed to explain the pathogenesis of I/R injury, most of the attention has focused on the role of reactive oxygen species (ROS), such as superoxide radical (O 2 − ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH − ). [4] Although all molecules are susceptible to ROS injury, lipids are targeted most frequently.…”

“…[3,14] Additionally, N-acetylcysteine, α-tocopherol, and melatonin administered to rats following I/R decrease the ROS levels providing kidney damage protection. [2,3,[13][14][15] Several experimental studies suggest that antioxidant vitamins, including ascorbic acid (AA), produce cytoprotective effects due to reduction of ROS. [16] Thus, AA is a very powerful antioxidant agent.…”

N-acetilcisteína e deferoxamina protegem contra insuficiência renal aguda induzida por isquemia/reperfusão em ratos

“…(9) The migration of neutrophils into the injured kidney following reperfusion leads to increased renal myeloperoxidase (MPO) activity, suggesting that chlorinated species could play a role in kidney damage. (10) In an effort to minimize these events, studies have used antioxidants, such as N-acetylcysteine (11) and deferoxamine. (12) N-acetylcysteine (NAC) is an antioxidant that acts by increasing intracellular levels of glutathione, enhancing glutathione-S-transferase activity, and scavenging ROS.…”