Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model

Yalcin, Alper; Gürel, Ali

doi:10.1080/10520295.2021.1883738

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…In addition, irisin level was found to be lower in conditions that increase oxidative stress, such as type 2 diabetes [18,34], chronic kidney disease [35], Behçet's disease [36], and chronic obstructive pulmonary disease [37]. As reported in the previous research [18,34,35,36,37], CP-generated oxidative stress resulted from a significant decrease of irisin expression in the myocardial tissue of rats in contrast to the control group in the current study. In contrast to the CP group, the CP+β-glucan group showed increased irisin immunoreactivity.…”

Section: Discussionsupporting

confidence: 74%

“…Irisin and caspase-3 expressions were evaluated within myocardial tissue sections. For immunohistochemical staining, the sections taken on adhesive slides were immunostained with irisin (1:200, Catalog number: H-067-17, Phoenix Pharmaceuticals, Inc.) and caspase-3 (1:200, ab184787, Abcam) primary antibodies and evaluated according to the literature [18]. The histoscore was calculated using the following rating scale to represent the occurrence of irisin and caspase-3 immunoreactivity in heart tissue: 0.1: <25%, 0.4: 26−50%, 0.6: 51−75%; 0.9: 76−100%, and intensity of immunoreactivity as 0: unstained, +0.5: very low, +1: low, +2: moderate, +3: severe.…”

Section: Immunohistochemical Analysismentioning

confidence: 99%

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Beta-glucan: A powerful antioxidant to overcome cyclophosphamide-induced cardiotoxicity in rats

Metin¹,

Türk²,

Yalcin³

2022

Med-Science

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Cyclophosphamide (CP) is a common chemotherapeutic drug; however, it does have several toxic side effects, including cardiotoxicity. Beta (β)-glucan is a free radical scavenger and powerful antioxidative molecule. The effects of β-glucan on CP-induced cardiotoxicity were investigated in this experimental study. Twenty-eight Wistar albino rats were divided into the following four equal groups: control (no treatment), CP (200 mg/kg CP, intraperitoneally on day 2), β-glucan (50 mg/kg β-glucan, oral gavage for seven days), and CP+β-glucan (200 mg/kg CP, intraperitoneally on day 2+50 mg/kg β-glucan, oral gavage for seven days) groups. Histopathology, irisin, and caspase-3 expressions were evaluated in ventricular myocardial tissues. The CP group exhibited considerably more severe cardiac damage than the control group, according to histological evaluation. Immunohistochemically irisin expression was decreased, and caspase-3 expression was much higher in the CP group. β-glucan, on the other hand, improved histopathological changes and exhibited a protective potential against CP-induced cardiac tissue damage when combined with the CP group. Our findings showed that β-glucan could act as an effective cardioprotective molecule against the toxic effects caused by CP.

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Section: Discussionsupporting

confidence: 74%

Section: Immunohistochemical Analysismentioning

confidence: 99%

Beta-glucan: A powerful antioxidant to overcome cyclophosphamide-induced cardiotoxicity in rats

Metin¹,

Türk²,

Yalcin³

2022

Med-Science

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“…Meanwhile, N-acetylcysteine is an antioxidant that reduces ALI inflammation, asthmatic airway and emphysema formation as well as attenuates pulmonary fibrosis (Zhang et al, 2014;Breau et al, 2019;Lee et al, 2020;Zhao et al, 2022). It also has an important role in lung diseases and elevates irisin levels as well as attenuates oxidative stress and tissue damage in a diabetes model (Yalçın and Gürel, 2021). Furthermore, longacting muscarinic receptor antagonists are bronchodilators that are one of the mainstays in the treatment of asthma and COPD.…”

Section: Traditional Therapeutic Drugsmentioning

confidence: 99%

Potential role of irisin in lung diseases and advances in research

Dong,

Lv,

Gao

et al. 2023

Front. Pharmacol.

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Irisin, a myokine, is secreted by the movement of skeletal muscles. It plays an important role in metabolic homeostasis, insulin resistance, anti-inflammation, oxidative stress, and bone metabolism. Several studies have reported that irisin-related signaling pathways play a critical role in the treatment of various diseases, including obesity, cardiovascular disease, diabetes, and neurodegenerative disorders. Recently, the potential role of irisin in lung diseases, including chronic obstructive pulmonary disease, acute lung injury, lung cancer, and their associated complications, has received increasing attention. This article aims to explore the role of irisin in lung diseases, primarily focusing on the underlying molecular mechanisms, which may serve as a marker for the diagnosis as well as a potential target for the treatment of lung diseases, thus providing new strategies for their treatment.

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The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lep^ob/J Type 2 Diabetic Mice

Maartens

Kruger

Vyver

2021

Stem Cells and Development

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Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model

Cited by 5 publications

References 28 publications

Beta-glucan: A powerful antioxidant to overcome cyclophosphamide-induced cardiotoxicity in rats

Beta-glucan: A powerful antioxidant to overcome cyclophosphamide-induced cardiotoxicity in rats

Potential role of irisin in lung diseases and advances in research

The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lep^ob/J Type 2 Diabetic Mice

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Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model

Cited by 5 publications

References 28 publications

Beta-glucan: A powerful antioxidant to overcome cyclophosphamide-induced cardiotoxicity in rats

Beta-glucan: A powerful antioxidant to overcome cyclophosphamide-induced cardiotoxicity in rats

Potential role of irisin in lung diseases and advances in research

The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lepob/J Type 2 Diabetic Mice

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The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lep^ob/J Type 2 Diabetic Mice