Effects of nano particles on antigen-related airway inflammation in mice

Inoue, Ken‐ichiro; Takano, Hirohisa; Yanagisawa, Rie; Sakurai, Miho; Ichinose, Takamichi; Sadakane, Kaori; Yoshikawa, Toshikazu

doi:10.1186/1465-9921-6-106

Cited by 93 publications

(80 citation statements)

References 51 publications

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“…We suggest the following preventive measures: a wide laparotomy to control the inferior vena cava and have an extracorporeal bypass ready. These guidelines may prevent the fatal intraoperative pulmonary embolism as previously reported, and which occurred in two patients from our series [2].…”

supporting

confidence: 72%

“…First, we are interested in the (estimated) total weight of the polyacrylate nanoparticles detected in the lungs and/or pleural fluids obtained from the patients. In our in vivo experiments, mice were exposed seven times per week to nanoparticles (carbon black [2] and latex [3]) at the weight of 50 mg?time…”

Section: Effects Of Nanoparticles On Lung Damage In Humansmentioning

confidence: 99%

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Effects of nanoparticles on lung damage in humans

Inoue¹,

Takano²

2009

Eur Respir J

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supporting

confidence: 72%

Section: Effects Of Nanoparticles On Lung Damage In Humansmentioning

confidence: 99%

Effects of nanoparticles on lung damage in humans

Inoue¹,

Takano²

2009

Eur Respir J

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“…These findings suggest that sensitization with MWCNT and antigen can exacerbate allergic asthmatic responses associated with increased levels of antigen specific antibodies. It has been reported that nano-sized particles, including TiO 2 and carbon black, have more prominent adjuvant effects on allergen-specific responses with Ig production [22][23][24] ; however, latex nanoparticles do not facilitate these responses. 25) These previous observations suggest that each nano-level particle has different effects on this pathology, which may depend on their characteristics.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Multiwalled Carbon Nanotubes and Allergen Promotes Early- and Late-Phase Increases in Airway Resistance in Mice

Mizutani

Nabe

Yoshino

2012

Biological & Pharmaceutical Bulletin

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The facilitating effects of multiwalled carbon nanotubes (MWCNT) on allergic asthma have not been sufficiently examined, although MWCNT appear to significantly increase the risk of health problems from occupational or environmental exposure. In this study, we examined whether sensitization by the combination of MWCNT with ovalbumin (OVA) promotes allergic asthmatic responses. BALB/c mice administered vehicle, MWCNT, OVA, or MWCNT OVA through an intranasal route were challenged with OVA intratracheally four times. In the MWCNT OVA group, the fourth challenge caused not only early-but also latephase increases in airway resistance, although these responses were not observed in the vehicle, MWCNT, or OVA group; furthermore, the extents of the early and late responses were comparable to those in mice systemically sensitized with OVA alum. Sensitization with MWCNT and OVA promoted airway inflammation and goblet cell hyperplasia in the lung compared with the vehicle, MWCNT or OVA group. In addition, adjuvant activity for OVA-specific immunoglobulin E (IgE), IgG1, and IgG2a production in serum and increased levels of interleukin-4 (IL-4), IL-5, IL-13, and IL-17 in the lung tissue were observed. In conclusion, these results suggest that exposure to MWCNT and antigen can induce a biphasic increase in airway resistance, airway inflammation, goblet cell hyperplasia, and the production of antigen-specific antibodies. This study highlights the risk of exposure to a combination of MWCNT with antigen.Key words carbon nanotube; allergic asthma; airway resistance; goblet cell hyperplasia; adjuvant activity Allergic asthma is a chronic type of airway inflammation characterized by reversible airway obstruction and goblet cell hyperplasia associated with elevated levels of allergen-specific immunoglobulin E (IgE).1-3) The prevalence of asthma has increased markedly over the past 3 decades, and may be due to changes in environmental factors, including indoor and outdoor air pollution. 4,5) Relatively few investigations on the environmental exacerbating factors of the pathology have been conducted, although intensive experiments have accumulated evidence regarding the molecular mechanisms of therapeutic targets. The former type of research should be focused on, since large environmental changes may occur throughout the world in the future.Nanotechnology is now advancing at an incredible pace, such that it has created an alternative industrial revolution over the past few years. 6) Consistent with this, the use of engineered nanomaterials has been rapidly increasing in commercial applications. As these materials have become more widespread, many questions have arisen regarding the effects of these materials as inhalable toxicants. Among several different types of nanomaterials, carbon nanotubes (CNT) are one of the most attractive materials because of their unique physical and chemical characteristics, including their size (1-20 nm width and many micrometers in length), strength, and surface chemistry. 7,8) However, CNT show marked cyt...

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“…Nanoparticles can aggravate allergenrelated airway inflammation and immunoglobulin production, being more prominent with smaller particles. The enhancement may be mediated, at least partly, by increased local expression of IL-5 and eotaxin, and also by modulated expression of IL-13, RANTES, MCP-1, and IL-6 [47].…”

Section: Effects Of Nanoparticles On Allergic Airway Inflammationmentioning

confidence: 99%

Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases

Inoue

2010

Environ Health Prev Med

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Although the adverse health effects of nanoparticles/materials have been proposed and are being clarified, their facilitating effects on preexisting pathological conditions have not been fully established. We provide insights into the environmental immunotoxicity of nanoparticles as an aggravating factor in hypersusceptible subjects, especially those with respiratory disorders, using our in vivo models. We first examined the effects of nanoparticles/materials on lung inflammation induced by bacterial endotoxin (lipopolysaccharide) as a test model against innate immunity, and demonstrated that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate lung inflammation. Secondly, we examined the effects of nanoparticles/materials on allergic pathophysiology, and showed that repetitive pulmonary exposure to nanoparticles has aggravating effects on allergic airway inflammation, including adjuvant effects on Th2-milieu. Taken together, nanoparticle exposure may synergistically facilitate pathological inflammatory conditions in the lung via both innate and adaptive immunological abnormalities.

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Effects of nano particles on antigen-related airway inflammation in mice

Cited by 93 publications

References 51 publications

Effects of nanoparticles on lung damage in humans

Effects of nanoparticles on lung damage in humans

Exposure to Multiwalled Carbon Nanotubes and Allergen Promotes Early- and Late-Phase Increases in Airway Resistance in Mice

Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases

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