Effects of nanostructuration on the electrochemical performance of metallic bioelectrodes

Mobini, Sahba; González, Marı́a Ujué; Caballero‐Calero, Olga; Patrick, Erin; Martín‐González, Marisol; García-Martín, José Miguel

doi:10.1039/d1nr06280h

Cited by 9 publications

(3 citation statements)

References 58 publications

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“…( Zimmermann et al, 2021 ). Ultimately, the choice of electrode material and electrochemical characterisation of the set up will be critical to determine a biologically safe stimulation regime, which delivers the required amount of charge without splitting the water or producing toxic faradaic by-products ( Boehler et al, 2020 ; Mobini et al, 2022 ).…”

Section: Future Workmentioning

confidence: 99%

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

O’Hara-Wright

Mobini

Gonzalez‐Cordero

2022

Front. Cell Dev. Biol.

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Pluripotent stem cell-derived organoid models of the central nervous system represent one of the most exciting areas in in vitro tissue engineering. Classically, organoids of the brain, retina and spinal cord have been generated via recapitulation of in vivo developmental cues, including biochemical and biomechanical. However, a lesser studied cue, bioelectricity, has been shown to regulate central nervous system development and function. In particular, electrical stimulation of neural cells has generated some important phenotypes relating to development and differentiation. Emerging techniques in bioengineering and biomaterials utilise electrical stimulation using conductive polymers. However, state-of-the-art pluripotent stem cell technology has not yet merged with this exciting area of bioelectricity. Here, we discuss recent findings in the field of bioelectricity relating to the central nervous system, possible mechanisms, and how electrical stimulation may be utilised as a novel technique to engineer “next-generation” organoids.

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Section: Future Workmentioning

confidence: 99%

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

O’Hara-Wright

Mobini

Gonzalez‐Cordero

2022

Front. Cell Dev. Biol.

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“…The process is rather complicated, which is hard to be modeled by a single resistor or capacitor. Instead, experimentally, the impedances of bioelectrodes fit well by a constant phase element [4], which is an imaginary and mathematical electronic component. The underlying mechanism remains unclear [5], [6].…”

Section: Introductionmentioning

confidence: 97%

A High-Precision Circuit-Simulator-Compatible Model for Constant Phase Element Using Rational Function Approximation

Hou

Guo

Bance

et al. 2023

IEEE J. Electron Devices Soc.

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Constant phase elements (CPEs) are commonly used in bioelectronic systems, to model the impedance of bioelectrodes and electrode-electrolyte interfaces. To simulate the systems with an electronic design automation tool, a circuit-simulatorcompatible model of the CPE is required to use bioelectrodes in circuit simulation. This paper applies rational function approximation to the impedance of CPEs as a function of frequency, which is able to be implemented with Verilog-A language. In comparison to previously published works which simply approximate a CPE into several serially connected RCs, our work illustrates the theoretical basis behind the approximation with RCs and provides a method perform the approximation, thus resulting in a smaller relative root mean square error of impedance magnitude and phase (4 orders of magnitude lower using 25 RCs) within a bounded frequency range. To validate the model accuracy, it is applied to the modeling of human cochleae, with the simulated results correlating well with the measured results. Furthermore, this model is implemented in a circuit that includes a bioelectrode and a thin-film transistor switch, showing the capability for circuit simulation with CPEs.

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“…These features make them good candidates for the development of numerous technological devices, such as gas or liquid sensors, optical coatings, and electrodes or instruments for fluid manipulation, among others [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. They are also applied in biomedicine, as the surface energy of the film and its interaction with living organisms can be tuned by modifying the features of the columnar arrangement [27,28]. In all these cases, and aside from the chemical composition of the film, a key feature defining their functionality resides in the characteristics of the porous structure.…”

Section: Introductionmentioning

confidence: 99%

Structure and Void Connectivity in Nanocolumnar Thin Films Grown by Magnetron Sputtering at Oblique Angles

Alvarez,

Regodon,

Acosta-Rivera

et al. 2023

Coatings

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The morphology and void connectivity of thin films grown by a magnetron sputtering deposition technique at oblique geometries were studied in this paper. A well-tested thin film growth model was employed to assess the features of these layers along with experimental data taken from the literature. A strong variation in the film morphology and pore topology was found as a function of the growth conditions, which have been linked to the different collisional transport of sputtered species in the plasma gas. Four different characteristic film morphologies were identified, such as (i) highly dense and compact, (ii) compact with large, tilted mesopores, (iii) nanocolumns separated by large mesopores, and (iv) vertically aligned sponge-like coalescent nanostructures. Attending to the topology and connectivity of the voids in the film, the nanocolumnar morphology was shown to present a high pore volume and area connected with the outside by means of mesopores, with a diameter above 2 nm, while the sponge-like nanostructure presented a high pore volume and area, as well as a dense network connectivity by means of micropores, with a diameter below 2 nm. The obtained results describe the different features of the porous network in these films and explain the different performances as gas or liquid sensors in electrochromic applications or for infiltration with nanoparticles or large molecules.

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Effects of nanostructuration on the electrochemical performance of metallic bioelectrodes

Abstract: The use of metallic nanostructures in the fabrication of bioelectrodes (e.g., neural implants) is gaining attention nowadays. Nanostructures provide increased surface area that might benefit the performance of bioelectrodes. However,...

Cited by 9 publications

References 58 publications

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

A High-Precision Circuit-Simulator-Compatible Model for Constant Phase Element Using Rational Function Approximation

Structure and Void Connectivity in Nanocolumnar Thin Films Grown by Magnetron Sputtering at Oblique Angles

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