Effects of Natural Brown Cotton Bleached Gauze on Wound Healing

Xu, Jingying; Su, Miao; Jin, Zimin; Zhou, Wenlong; Sun, Yuqiang; Jin, Youyi; Shi, Zhansong

doi:10.3390/ma15062070

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…It can plausibly be attributed to the adequate solubility of CUR–PYR that causes the produced ointment adheres easily to the wound bed and stays there for several hours. Reviewing previous literature shows that numerous advanced dressings have been suggested to help wound healing by providing balanced moisture to the wound site. ,,− Regarding the greater importance of re-epithelialization than contraction in human wound repair, on the other hand, several materials like foils, splints and human-mouse xenografts have been examined to avoid contraction during wound repair. − Surprisingly, our suggested drug without any supplementary dressing or tool is capable of keeping an open wound desirably hydrated coordinating wound contraction and re-epithelialization during wound healing. This prominent feature finally results in accelerated skin regeneration.…”

Section: Resultsmentioning

confidence: 99%

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Samie,

Alavian,

Vafaei-Pour

et al. 2023

Mol. Pharmaceutics

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Pharmaceutical cocrystals (Regulatory Classification of Pharmaceutical Co-Crystals Guidance for Industry; Food and Drug Administration, 2018) are crystalline solids produced through supramolecular chemistry to modulate the physicochemical properties of active pharmaceutical ingredients (APIs). Despite their extensive development in interdisciplinary sciences, this is a pioneering study on the efficacy of pharmaceutical cocrystals in wound healing and scar reducing. Curcumin−pyrogallol cocrystal (CUR−PYR) was accordingly cherry-picked since its superior physicochemical properties adequately compensate for limitative drawbacks of curcumin (CUR). CUR− PYR has been synthesized by a liquid-assisted grinding (LAG) method and characterized via FT-IR, DSC, and PXRD analyses. In vitro antibacterial study indicated that CUR−PYR cocrystal, CUR+PYR physical mixture (PM), and PYR are more effective against both Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria in comparison with CUR. In vitro results also demonstrated that the viability of HDF and NIH-3T3 cells treated with CUR−PYR were improved more than those received CUR which is attributed to the effect of PYR in the form of cocrystal. The wound healing process has been monitored through a 15 day in vivo experiment on 75 male rats stratified into six groups: five groups treated by CUR−PYR+Vaseline (CUR−PYR.ung), CUR+PYR+Vaseline (CUR+PYR.ung), CUR+Vaseline (CUR.ung), PYR+Vaseline (PYR.ung), and Vaseline (VAS) ointments and a negative control group of 0.9% sodium chloride solution (NS). It was revealed that the wounds under CUR−PYR.ung treatment closed by day 12 postsurgery, while the wounds in other groups failed to reach the complete closure end point until the end of the experiment. Surprisingly, a diminutive scar (3.89 ± 0.97% of initial wound size) was observed in the CUR−PYR.ung treated wounds by day 15 after injury, followed by corresponding values for PYR.ung (12.08 ± 2.75%), CUR+PYR.ung (13.89 ± 5.02%), CUR.ung (16.24 ± 6.39%), VAS (18.97 ± 6.89%), and NS (20.33 ± 5.77%). Besides, investigating histopathological parameters including inflammation, granulation tissue, reepithelialization, and collagen deposition signified outstandingly higher ability of CUR−PYR cocrystal in wound healing than either of its two constituents separately or their simple PM. It was concluded that desired solubility of the prepared cocrystal was essentially responsible for accelerating wound closure and promoting tissue regeneration which yielded minimal scarring. This prototype research suggests a promising application of pharmaceutical cocrystals for the purpose of wound healing.

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Section: Resultsmentioning

confidence: 99%

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Samie,

Alavian,

Vafaei-Pour

et al. 2023

Mol. Pharmaceutics

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“…After opening the software, the wound image was imported, the composition shape that fits the wound, and the average value. 15 On the 15th day, mice were euthanized. Skin tissues were fixated in 10% formalin solution, processed, and embedded in paraffin.…”

Section: Experimental Animal Preparationmentioning

confidence: 99%

Effectiveness of Black Soldier Fly (Hermetia illucens) Prepupa Oil Emulgel for Burn Wound Recovery

2024

TJNPR

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“…They protect the wound, allowing drainage onto a secondary absorbent dressing [ 41 ]. One of the most significant problems encountered by using this material is a foreign body reaction in the wound caused by cotton fibers [ 42 ]. Clinical signs more frequently observed after gauze and tape dressing use are skin maceration and hyperemia; the biggest advantage is their low cost and the possibility of being formulated in many forms as tapes, rolls, or adhesive patches [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Prete,

Dattilo,

Patitucci

et al. 2023

JFB

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Biomaterials are at the forefront of the future, finding a variety of applications in the biomedical field, especially in wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try to heal through a series of interconnected processes involving several initiators and mediators such as cytokines, macrophages, and fibroblasts. The combination of biopolymers with wound healing properties may provide opportunities to synthesize matrices that stimulate and trigger target cell responses crucial to the healing process. This review outlines the optimal management and care required for wound treatment with a special focus on biopolymers, drug-delivery systems, and nanotechnologies used for enhanced wound healing applications. Researchers have utilized a range of techniques to produce wound dressings, leading to products with different characteristics. Each method comes with its unique strengths and limitations, which are important to consider. The future trajectory in wound dressing advancement should prioritize economical and eco-friendly methodologies, along with improving the efficacy of constituent materials. The aim of this work is to give researchers the possibility to evaluate the proper materials for wound dressing preparation and to better understand the optimal synthesis conditions as well as the most effective bioactive molecules to load.

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Effects of Natural Brown Cotton Bleached Gauze on Wound Healing

Cited by 7 publications

References 14 publications

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Accelerated Wound Healing with a Diminutive Scar through Cocrystal Engineered Curcumin

Effectiveness of Black Soldier Fly (Hermetia illucens) Prepupa Oil Emulgel for Burn Wound Recovery

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

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