Effects of natural compounds in treatment and prevention of hepatotoxicity and hepatocellular carcinoma

Abstract

Liver diseases are most common disorders in the world and characterized by rapid changes from steatosis to chronic hepatitis, fi brosis, cirrhosis, and hepatocellular carcinoma (HCC). Natural products that attained great attention is to be used in the prevention and treatment of multiple diseases in humans. Several researches have been reported numerous natural and phytochemical compounds that may counteract or prevent the hepatic injury and primary liver cancer. The conservative treatment of liver toxicity and HCC may face awkward challenges in chemotherapy such as therapeutic failure or drug resistance. Accordingly, there is an actual need for safe and effective therapeutic and preventive modalities for liver disorders. The present review aims to focus on the potential protective and therapeutic effects of natural compounds in the prevention and treatment of hepatotoxicity and HCC. It also demonstrates the mechanism of the natural products in enzymatic regulation of antioxidants and its role in apoptosis and proliferation of cancerous lesions of hepatocytes. Accordingly, it highlights the promising role of natural bioactive compounds and provides the rational for further transitional researches, and emphasize on the scientifi c validation of natural compounds for therapeutic portfolio for clinical use in liver diseases.

Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms

“…Thus, under the conditions of analysis established, ginkgo without additives were neither cytotoxic nor genotoxic. The results of nontoxic action at the cellular level of ginkgo without industrialization obtained in the present study corroborate the results of non-cytotoxicity and nongenotoxicity of this plant found in the scientific literature, including the studies of Turkez et al (2014), Hamzawy et al (2015) and Oliveira et al (2017). Table 1.…”

“…Leaves of Ginkgo biloba L. (Family Ginkgoaceae), a species native to Eastern countries, such as China and Japan, have long been used for the treatment and prevention of cardiopulmonary dysfunctions, labyrinthitis and diseases triggered by senescence (POLANSKI et al, 2016;MAHMOUDIAN-SANI et al, 2017). This plant also has recognized antioxidant potential (HAMZAWY et al, 2015). It is popularly known as ginkgo or maidenhair tree, and has high concentrations of ginkgolide diterpenes, bilobalide sesquiterpenes, triterpenes, polyphenols, ginkgolide acids, flavones, flavonols and biflavonoids in the foliage (POLANSKI et al, 2016).…”

“…Tea of fresh ginkgo leaves was evaluated for its toxic potential at the cellular level, and it was verified that this plant was neither cytotoxic nor genotoxic to the bioassays used. Furthermore, fresh ginkgo was found to have a repairing effect on cell damage to tissues previously treated with clastogenic drugs (TURKEZ et al, 2014;HAMZAWY et al, 2015;OLIVEIRA et al, 2017).…”

The Effect of Silybum Marianum Seed, Thymus Vulgaris, and Rosmarinus Officinalis Powders in Alleviating the Risks of Aflatoxin B1 in Young Broiler Chicks

“…During the experiment, all the environmental conditions were the same for the treatments, receiving food and water, ad 6) Positive control + 10 g/kg diet of SMS + 10 g/kg diet of TV + 5 g/kg diet of RO as blend of herbs (BH). The selection of aflatoxin B1 and herbs doses employed in this experiment was based on previous studies (Zhao et al, 2010;Chand et al, 2011;Hamzawy et al, 2012). The herbs utilized in the experiment were freshly harvested (whole aerial organs of RO and TV and the seeds of SMS), and dried, added to the diet as additive.…”

Role of natural antioxidants in the therapeutic management of hepatocellular carcinoma

“…It is effective as anthelmintic, antispasmodic, carminative, sedative, diaphoretic, antimicrobial, antioxidant, and antifungal agents because its contents of essential oils and anti-oxidative phenolic compounds [geraniol (G), α-terpineol (A), thuyanol-4 (U), linalool (L), carvacrol (C), and thymol (T)]. [131,132] The volatile oils of thyme has been shown to exhibit anti-microbial, anti-mutagenic, anti-platelet, analgesic, anti-inflammatory, anti-angiogenic, anti-oxidant, anti-elastase, insecticidal, anti-parasitic, cell-protective, and anti-tumor activity. [133,134] Recently, the various studies showed that the beneficial effects of thyme was based on the activation of the apoptosis response, including reduction in mitochondrial membrane capacity and Bcl-2/Bax ratio as well as elevation in cytochrome release from mitochondria and caspase activity.…”